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Sleep Loss and Hypertension: A Systematic Review
Abstract
Hypertension and insomnia are very common and often coexist. There is evidence to suggest that the increasing prevalence of arterial hypertension in the past decade might be related both to an increased prevalence of insomnia and to the decline of sleep duration due to modern lifestyle. The aim of this paper is to reconsider both the clinical evidence of the relationship between conditions of sleep loss and of perceived impairment in sleep quality with hypertension and the potential pathophysiological mechanisms underlying the biological plausibility of their relationship. Through a systematic search from MEDLINE, EMBASE, PsychINFO we selected articles, which reported experimental sleep deprivation designs, or studied sleep duration or insomnia and their relationship with blood pressure or hypertension in participants over 18 years. This analysis shows that experimental sleep deprivation, short sleep duration, and persistent insomnia are associated with increased blood pressure and increased risk of hypertension, even after controlling for other risk factors. Pathophysiological mechanisms underlying this association might be related to inappropriate arousal ("hyperarousal") due to an overactivation of stress system functions. According this hypothesis, prolonged sleep loss or alterations of sleep quality might act as a neurobiological and physiologic stressor that impair brain functions and contribute to allostatic load, compromising stress resilience and somatic health.
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Citations
Cited by
European guideline for the diagnosis and treatment of insomnia
Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., Espie, C. A., Garcia‐Borreguero, D., Gjerstad, M., Gonçalves, M., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12594 · Cited by 2,049
Self-citationWhy Sleep Is Important for Health: A Psychoneuroimmunology Perspective
Irwin, M. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115205 · Cited by 1,325
“…well as complaints of sleep maintenance and early-morning awakening, but not difficulty falling asleep, predicted an increased risk of hypertension; another systematic review (Palagini et al. 2013) as well as a largescale epidemiologic study (n = 4,794) (Suka et al. 2003) had similar conclusions.”
ResultHealth consequences of shift work and insufficient sleep
Kecklund, G., & Axelsson, J. (2016) · BMJ · doi:10.1136/bmj.i5210 · Cited by 1,195
Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., Grassi, G., Jordan, J., Poulter, N. R., Rodgers, A., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.14 · Cited by 1,167
Panel, C. C., Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.4886 · Cited by 906
Zachariae, R., Lyby, M. S., Ritterband, L. M., & O'Toole, M. S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.10.004 · Cited by 704
“[5] Palagini L, Bruno RM, Gemignani A, Baglioni C, Ghiadoni L, Riemann D.”
BackgroundKalmbach, D. A., Anderson, J. R., & Drake, C. L. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12710 · Cited by 620
“, 2011; Riemann & Voderholzer, 2003) and cardiometabolic health (Palagini et al., 2013; Vgontzas, Fernandez-Mendoza, Liao, & Bixler, 2013) and heavily burdens the Received: 1 March 2018 | Revised: 12 April 2018 | Accepted: 13 April 2018”
BackgroundWatson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., Kushida, C., et al. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4950 · Cited by 568
Hammerschlag, A. R., Stringer, S., de Leeuw, C. A., Sniekers, S., Taskesen, E., Watanabe, K., Blanken, T. F., Dekker, K., te Lindert, B. H. W., Wassing, R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3888 · Cited by 289
Chronic sleep loss during pregnancy as a determinant of stress: impact on pregnancy outcome
Palagini, L., Gemignani, A., Banti, S., Manconi, M., Mauri, M., & Riemann, D. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.02.013 · Cited by 220
Self-citationNeurobiological and Hormonal Mechanisms Regulating Women’s Sleep
Dorsey, A., de Lecea, L., & Jennings, K. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.625397 · Cited by 100
Outcome-Driven Thresholds for Increased Home Blood Pressure Variability
Juhanoja, E. P., Niiranen, T. J., Johansson, J. K., Puukka, P. J., Thijs, L., Asayama, K., Langén, V. L., Hozawa, A., Aparicio, L. S., Ohkubo, T., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08603 · Cited by 83
The relationship between sleep and problematic smartphone use among adolescents: A systematic review
Mac Cárthaigh, S., Griffin, C., & Perry, J. (2020) · Developmental Review · doi:10.1016/j.dr.2020.100897 · Cited by 75
Palagini, L., Bramante, A., Baglioni, C., Tang, N., Grassi, L., Altena, E., Johann, A. F., Geoffroy, P. A., Biggio, G., Mencacci, C., et al. (2022) · Archives of Women's Mental Health · doi:10.1007/s00737-022-01226-8 · Cited by 42
Self-citationPalagini, L., Ong, J. C., & Riemann, D. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.03.001 · Cited by 34
Self-citationSauvet, F., Arnal, P. J., Tardo-Dino, P. E., Drogou, C., Van Beers, P., Bougard, C., Rabat, A., Dispersyn, G., Malgoyre, A., Leger, D., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.01.049 · Cited by 32
Metadata
- Authors
- Palagini, L., Maria Bruno, R., Gemignani, A., Baglioni, C., Ghiadoni, L., & Riemann, D.
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2013-03-01
- Volume
- 19
- Issue
- 13
- Pages
- 2409-2419
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W2147600102
- Cited by
- 293
- References
- 0
- FWCI
- 31.94
- Type
- journal article
- Language
- en
- Open access
- closed
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