The DOI matches its Crossref record; 207 of the 207 references it cites were found in a registry or an index.
Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review
Open accessAbstract
Alzheimer's dis ease (AD) is a leading cause of mortality in the developed world with 70% risk attributable to genetics. The remaining 30% of AD risk is hypothesized to include environmental factors and human lifestyle patterns. Environmental factors possibly include inorganic and organic hazards, exposure to toxic metals (aluminium, copper), pesticides (organochlorine and organophosphate insecticides), industrial chemicals (flame retardants) and air pollutants (particulate matter). Long term exposures to these environmental contaminants together with bioaccumulation over an individual's life-time are speculated to induce neuroinflammation and neuropathology paving the way for developing AD. Epidemiologic associations between environmental contaminant exposures and AD are still limited. However, many in vitro and animal studies have identified toxic effects of environmental contaminants at the cellular level, revealing alterations of pathways and metabolisms associated with AD that warrant further investigations. This review provides an overview of in vitro, animal and epidemiological studies on the etiology of AD, highlighting available data supportive of the long hypothesized link between toxic environmental exposures and development of AD pathology.
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Cites
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Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution
Chen, R., Hu, B., Liu, Y., Xu, J., Yang, G., Xu, D., & Chen, C. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.03.019 · Cited by 388
Amyloid Beta in Aging and Alzheimer’s Disease
Sehar, U., Rawat, P., Reddy, A. P., Kopel, J., & Reddy, P. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112924 · Cited by 361
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Gangemi, S., Miozzi, E., Teodoro, M., Briguglio, G., De Luca, A., Alibrando, C., Polito, I., & Libra, M. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5817 · Cited by 169
Alzheimer’s Disease: Exploring the Landscape of Cognitive Decline
Tenchov, R., Sasso, J. M., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00339 · Cited by 170
Metadata
- Authors
- Yegambaram, M., Manivannan, B., Beach, T., & Halden, R.
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-02-24
- Volume
- 12
- Issue
- 2
- Pages
- 116-146
- ISSN
- 1567-2050 (ISSN-L)
- OpenAlex
- W2112357575
- Cited by
- 273
- References
- 207
- FWCI
- 14.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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