Cited by 170Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Alzheimer’s Disease: Exploring the Landscape of Cognitive Decline

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Tenchov, Rumiana, Sasso, Janet M., Zhou, Qiongqiong Angela·2024·ACS Chemical Neuroscience

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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid beta plaques and tau protein tangles in the brain, along with neuroinflammation and synaptic dysfunction. Genetic factors, such as mutations in APP, PSEN1, and PSEN2 genes, as well as the APOE ε4 allele, contribute to increased risk of acquiring AD. Currently available treatments provide symptomatic relief but do not halt disease progression. Research efforts are focused on developing disease-modifying therapies that target the underlying pathological mechanisms of AD. Advances in identification and validation of reliable biomarkers for AD hold great promise for enhancing early diagnosis, monitoring disease progression, and assessing treatment response in clinical practice in effort to alleviate the burden of this devastating disease. In this paper, we analyze data from the CAS Content Collection to summarize the research progress in Alzheimer's disease. We examine the publication landscape in effort to provide insights into current knowledge advances and developments. We also review the most discussed and emerging concepts and assess the strategies to combat the disease. We explore the genetic risk factors, pharmacological targets, and comorbid diseases. Finally, we inspect clinical applications of products against AD with their development pipelines and efforts for drug repurposing. The objective of this review is to provide a broad overview of the evolving landscape of current knowledge regarding AD, to outline challenges, and to evaluate growth opportunities to further efforts in combating the disease.

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Authors
Tenchov, R., Sasso, J. M., & Zhou, Q. A.
Affiliations
American Chemical Society (US)
Corresponding author
Zhou, Qiongqiong Angela
Venue
ACS Chemical Neuroscience
Published
2024-10-11
Volume
15
Issue
21
Pages
3800-3827
ISSN
1948-7193 (ISSN-L)
OpenAlex
W4403334326
Cited by
170
References
293
Citations by year
2026: 115 · 2025: 53 · 2024: 2
FWCI
9.70
Type
journal article
Language
en
Open access
Locations
  • ACS Chemical Neuroscience (publishedVersion, cc-by)
  • ChemRxiv (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, cognitive decline, amyloid plaques, neuroinflammation, synaptic dysfunction, genetic risk factors, APP mutations, presenilin 1, presenilin 2, APOE ε4, disease-modifying therapy, biomarkers, early diagnosis, drug repurposing, comorbid diseases, therapeutic target, drug development pipeline
MeSH terms
Alzheimer Disease, Animals, Humans, Cognitive Dysfunction

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