Insulin Resistance as Common Molecular Denominator Linking Obesity to Alzheimer‘s Disease

Adipose Tissue as an Endocrine Organ

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2016 Alzheimer's disease facts and figures

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Inflammatory Mechanisms in Obesity

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

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Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

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A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

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Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

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Midlife and Late-Life Obesity and the Risk of Dementia: Cardiovascular Health Study

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Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

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Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

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Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

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Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta‐analysis

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The Alzheimer's disease Beta-secretase enzyme, BACE1

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Brain metabolic dysfunction at the core of Alzheimer's disease

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Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

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The Role of Insulin Resistance in the Pathogenesis of Alzheimer??s Disease

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Nitric oxide and neuronal death

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Longitudinal examination of obesity and cognitive function: results from the Baltimore Longitudinal Study of Aging

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Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease

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Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study

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Obesity‐related leptin regulates Alzheimer's Aβ

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Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer’s disease

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Insulin in the Brain: Sources, Localization and Functions

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Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors

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Relationship between body mass index and brain volume in healthy adults

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Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo

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Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression

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High-fat diets impair spatial learning in the radial-arm maze in mice

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Hsp60 chaperonopathies and chaperonotherapy: targets and agents

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Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

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THE GENETICS AND MOLECULAR PATHOLOGY OF ALZHEIMER'S DISEASE

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Decreased Levels of Circulating Adiponectin in Mild Cognitive Impairment and Alzheimer’s Disease

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Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

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Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

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Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells

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Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction‐induced Prevention of Alzheimer's Disease‐type Amyloid Neuropathology and Spatial Memory Deterioration

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Amyloid Precursor Protein Expression Is Upregulated in Adipocytes in Obesity

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Central Proliferation and Neurogenesis Is Impaired in Type 2 Diabetes and Prediabetes Animal Models

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Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice

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Obesity as a risk factor for Alzheimer’s disease: the role of adipocytokines

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An Integrated and Unifying Hypothesis for the Metabolic Basis of Sporadic Alzheimer's Disease

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Obesity, Insulin Resistance, and Alzheimer's Disease

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Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis

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Plasma Amyloid-β Peptide Levels Correlate with Adipocyte Amyloid Precursor Protein Gene Expression in Obese Individuals

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Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis

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Insulin‐activated Akt rescues Aβ oxidative stress‐induced cell death by orchestrating molecular trafficking

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Bidirectional metabolic regulation of neurocognitive function

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Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet

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Adiposity hormones and dementia

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Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology

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Hsp60 response in experimental and human temporal lobe epilepsy

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Resistin protection against endogenous Aβ neuronal cytotoxicity from mitochondrial pathway

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Obesity-Associated Cognitive Decline: Excess Weight Affects More than the Waistline

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A high fat diet does not exacerbate CA1 injury and cognitive deficits following global ischemia in rats

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Genes and obesity: A cause and effect relationship

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An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus

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Therapies for Prevention and Treatment of Alzheimer’s Disease

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Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

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Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease

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Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia

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Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

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Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

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Gene-environment interactions in Alzheimer's disease: A potential path to precision medicine

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Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases

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Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

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Neuropsychology of aging

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The complex relationship between obesity and neurodegenerative diseases: an updated review

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Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease

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Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

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The association between PGC-1α and Alzheimer's disease

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Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats

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Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42 and Phospho-Tau May Abet Alzheimer Development

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Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet

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Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet

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Butyrylcholinesterase: A Multifaceted Pharmacological Target and Tool

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Rapamycin preserves gut homeostasis during Drosophila aging

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Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review

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Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin

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Ozone atmospheric pollution and Alzheimer's disease: from epidemiological facts to molecular mechanisms

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Obesity and Alzheimer’s disease: Molecular bases

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Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Factors for Alzheimer's Disease

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Insulin and Its Key Role for Mitochondrial Function/Dysfunction and Quality Control: A Shared Link between Dysmetabolism and Neurodegeneration

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NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet

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A novel GLP‐1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease

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Design and Efficacy of Nanogels Formulations for Intranasal Administration

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The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia

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Enriching the Mediterranean diet could nourish the brain more effectively

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Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology

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Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer’s Like Pathology in Mice Brain

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Potential Roles of Adropin in Central Nervous System: Review of Current Literature

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Exploiting Common Aspects of Obesity and Alzheimer’s Disease

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The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model

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From Small Peptides to Large Proteins against Alzheimer’sDisease

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Preventive Impact of Long-Term Ingestion of Chestnut Honey on Glucose Disorders and Neurodegeneration in Obese Mice

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From obesity to Alzheimer's disease through insulin resistance

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