Cited by 78Air Quality and Health ImpactsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Ozone atmospheric pollution and Alzheimer's disease: from epidemiological facts to molecular mechanisms

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Croze, Marine L., Zimmer, Luc·2018·Journal of Alzheimer s Disease

Abstract

Atmospheric pollution is a well-known environmental hazard, especially in developing countries where millions of people are exposed to airborne pollutant levels above safety standards. Accordingly, several epidemiological and animal studies confirmed its role in respiratory and cardiovascular pathologies and identified a strong link between ambient air pollution exposure and adverse health outcomes such as hospitalization and mortality. More recently, the potential deleterious effect of air pollution inhalation on the central nervous system was also investigated and mounting evidence supports a link between air pollution exposure and neurodegenerative pathologies, especially Alzheimer's disease (AD). The focus of this review is to highlight the possible link between ozone air pollution exposure and AD incidence. This review's approach will go from observational and epidemiological facts to the proposal of molecular mechanisms. First, epidemiological and postmortem human study data concerning residents of ozone-severely polluted megacities will be presented and discussed. Then, the more particular role of ozone air pollution in AD pathology will be described and evidenced by toxicological studies in rat or mouse with ozone pollution exposure only. The experimental paradigms used to reproduce in rodent the human exposure to ozone air pollution will be described. Finally, current insights into the molecular mechanisms through which ozone inhalation can affect the brain and play a role in AD development or progression will be recapitulated.

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Crossref · 10.3233/jad-170857

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  • Deleterious effects of ozone exposure on the central nervous system are emerging.

    “Additionally, deleterious effects of ozone exposure on the central nervous system (CNS) are emerging (64, 65).”

    From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [65]

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  1. Chen H, Goldberg MS, Villeneuve PJ (2008) A system- atic review of the relation between long-term exposure to ambient air pollution and chronic diseases. Rev Environ Health 23, 243-297.

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Authors
Croze, M. L., & Zimmer, L.
Affiliations
  • Lyon 1 Université (FR)
  • Centre de Recherche en Neurosciences de Lyon (FR)
Corresponding author
  • Croze, Marine L.
  • Zimmer, Luc
Venue
Journal of Alzheimer s Disease
Published
2018-02-20
Volume
62
Issue
2
Pages
503-522
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2788689682
Cited by
78
References
118
Citations by year
2026: 8 · 2025: 11 · 2024: 16 · 2023: 12 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 1
FWCI
0.55
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
Funders
  • Agence Nationale de la Recherche (ANR-11-LABX-0063, ANR-11-IDEX-0007, ANR-11-IDEX, 11 IDEX - 0007)
  • Université de Lyon (ANR−11-LABX−0063, ANR-11-IDEX-0 0 07)
  • LabEx PRIMES (ANR-11-LABX-0063), ANR-11-IDEX- 0007)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
ozone, air pollution
MeSH terms
Air Pollution, Alzheimer Disease, Animals, Central Nervous System, Humans, Ozone, Incidence, Inhalation Exposure, Particulate Matter

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