The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Fluoroquinolones: Action and Resistance
Abstract
Fluoroquinolones trap gyrase and topoisomerase IV on DNA as ternary complexes that block the movement of replication forks and transcription complexes. Studies with resistant mutants indicate that during complex formation quinolones bind to a surface alpha-helix of the GyrA and ParC proteins. Lethal action is a distinct event that is proposed to arise from release of DNA breaks from the ternary complexes. Many bacterial pathogens are exhibiting resistance due to alterations in drug permeability, drug efflux, gyrase-protecting proteins, and target topoisomerases. When selection of resistant mutants is described in terms of fluoroquinolone concentration, a threshold (mutant prevention concentration, MPC) can be defined for restricting the development of resistance. MPC varies among fluoroquinolones and pathogens; when combined with pharmacokinetics, MPC can be used to identify compounds least likely to enrich mutant subpopulations. Use of suboptimal doses and compounds erodes the efficacy of the class as a whole because resistance to one quinolone reduces susceptibility to others and/or increases the frequency at which resistance develops. When using fluoroquinolones in combination therapy, the development of resistance may be minimized by optimizing regimens for pharmacokinetic overlap.
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Cites
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Self-citationDNA gyrase: an enzyme that introduces superhelical turns into DNA.
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Cited by
Molecular Mechanisms of Antibacterial Multidrug Resistance
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Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents
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The changing epidemiology of resistance
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Role of reactive oxygen species in antibiotic action and resistance
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The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
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Metadata
- Authors
- Drlica, K., & Malik, M.
- Venue
- Current Topics in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2003-01-01
- Volume
- 3
- Issue
- 3
- Pages
- 249-282
- ISSN
- 1568-0266 (ISSN-L)
- OpenAlex
- W2118813171
- Cited by
- 317
- References
- 158
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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