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Cited by 43Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsMusculoskeletal pain and rehabilitation

Psychosocial Vulnerability and Early Life Adversity as Risk Factors for Central Sensitivity Syndromes

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T. Jones, Gareth·2016·Current Rheumatology Reviews
DOI 10.2174/1573397112666151231113438
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Abstract

The aim of this narrative review of the epidemiology of central sensitivity syndromes is to provide a summary of the role of early life adversity and psychosocial / psychological factors, in the epidemiology of six main syndromes: (i) fibromyalgia / chronic widespread pain; (ii) headache / migraine; (iii) irritable bowel syndrome; (iv) temporomandibular joint disorder; (v) interstitial cystitis; and (vi) endometriosis / vulvodynia / chronic pelvic pain. The occurrence of each of the above syndromes vary between each other, and between studies. Prevalence ranges from interstitial cystitis, with a prevalence of approximately 14.5 per 100,000, to headache, with some estimates of lifetime prevalence to be around 66%. Precise risk estimates vary between studies, conditions, and exposures, although there is consistent evidence to suggest an association between early life adversity and central sensitivity syndromes (based on the six syndromes under investigation). In further support of this, a number of studies have also demonstrated dose-risk associations. There is also considerable consistency in the literature to suggest a strong association between negative psychological and psychosocial factors, and the occurrence of central sensitivity syndromes and, again, there is some evidence of a dose-risk relationship. The majority of studies in this field are cross-sectional or retrospective in design, and caution is advised when interpreting results. It is possible - indeed there is some evidence - that some findings may be subject to recall bias, and reverse causation is also a potential concern. However, there are also a number of prospective studies which provide more robust evidence.

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  • Women with endometriosis show a higher prevalence of systemic comorbidities.

    “Women with endometriosis show a higher prevalence of systemic comorbidities has been shown”

    From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [144]

    The Descriptive Epidemiology section reports that endometriosis and bladder pain syndrome are both common among women with chronic pelvic pain; it does not compare systemic comorbidities in women with and without endometriosis. Searches for systemic comorbidities, co-morbidity, and overlap found no passage establishing the claimed higher prevalence. Page numbers were not available in our copy. (LLM, conf=0.75)

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Research works printed but not linked: 8

  1. [2]2. Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990 Feb;33(2):160-72.
  2. [14]14. Scher A, Stewart WF, Lipton RB. Migraine and headache: a meta-analytic approach. In: Crombie IK, Croft PR, Linton SJ, LeResche, L., Von Korff M, editors. Epidemiology of pain-a report of the Task Force on Epidemiology of the International Association for the Study of Pain.Seattle: IASP Press; 1999. p. 159-70.
  3. [18]18. Canavan C, West J, Card T. The epidemiology of irritable bowel syndrome. Clin Epidemiol 2014;6:71-80.
  4. [36]36. Littlejohn C, Pang D, Power C, et al. Is there an association between preterm birth or low birthweight and chronic widespread pain? Results from the 1958 Birth Cohort Study. Eur J Pain 2012 Jan;16(1):134-9.
  5. [48]48. Salmon P, Skaife K, Rhodes J. Abuse, dissociation, and somatization in irritable bowel syndrome: towards an explanatory model. J Behav Med 2003 Feb;26(1):1-18.
  6. [69]69. Benjamin S, Morris S, McBeth J, et al. The association between chronic widespread pain and mental disorder: a population-based study. Arthritis Rheum 2000 Mar;43(3):561-7.
  7. [71]71. McBeth J, Macfarlane GJ, Benjamin S, et al. Features of somatization predict the onset of chronic widespread pain: results of a large population-based study. Arthritis Rheum 2001 Apr;44(4):940-6.
  8. [98]98. Gupta A, Kilpatrick L, Labus J, et al. Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences. Psychosom Med 2014 Jul;76(6):404-12.

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Authors
T. Jones, G.
Venue
Current Rheumatology Reviews
Publisher
Bentham Science Publishers Ltd.
Published
2016-06-03
Volume
12
Issue
2
Pages
140-153
ISSN
1573-3971 (ISSN-L)
DOI
10.2174/1573397112666151231113438
OpenAlex
W2409567073
Cited by
43
References
93
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 1
FWCI
2.17
Type
journal article
Language
en
Open access
Locations
  • Current Rheumatology Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords
central sensitivity syndromes, childhood adversity, psychosocial vulnerability, fibromyalgia, chronic widespread pain, migraine, headache, irritable bowel syndrome, temporomandibular disorders, interstitial cystitis, endometriosis, vulvodynia, chronic pelvic pain, prevalence, risk factors, dose-response relationship
MeSH terms
Endometriosis, Female, Fibromyalgia, Headache, Humans, Risk Factors, Stress, Psychological, Temporomandibular Joint Disorders, Pelvic Pain, Cystitis, Interstitial, Irritable Bowel Syndrome, Vulvodynia, Central Nervous System Sensitization, Chronic Pain

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