Magnetic Resonance Imaging of Amyloid Plaques in Transgenic Mouse Models of Alzheimers Disease
Open accessAbstract
A major objective in the treatment of Alzheimers disease is amyloid plaque reduction. Transgenic mouse models of Alzheimers disease provide a controlled and consistent environment for studying amyloid plaque deposition in Alzheimers disease. Magnetic resonance imaging is an attractive tool for longitudinal studies because it offers noninvasive monitoring of amyloid plaques. Recent studies have demonstrated the ability of magnetic resonance imaging to detect individual plaques in living mice. This review discusses the mouse models, MR pulse sequences, and parameters that have been used to image plaques and how they can be optimized for future studies. Keywords: MR microscopy, Alzheimer's disease, magnetic resonance imaging, magnetic resonance micro imaging, transgenic mice, amyloid, APP/PS1, SWI
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Only a fraction of mature plaques contain sufficient iron, and long scanning time is not appropriate for in vivo studies.
“Unfortunately only a fraction of mature plaques contain sufficient iron, and the long scanning time is not appropriate for in vivo studies.8”
From Amyloid Plaque Imaging with a Targeted MRI Contrast Agent in a Transgenic Mouse Model of Alzheimer’s Disease (2022) · cites this paper as [8]
The Ex Vivo Imaging section says that 8–24-hour and 10–11-hour scans were too long for in vivo imaging. The Optimizing Plaque Imaging section distinguishes iron-rich thalamic plaques from cortical and hippocampal plaques with much lower iron levels, but it does not say that only a fraction of mature plaques contain sufficient iron. Page numbers were not available in our copy. (LLM, conf=0.86)
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Cites
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“This is advantageous because we found that SWI can provide significantly greater plaque contrast than other techniques.”
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“This is because the T2 decay between echoes causes blurring in the final image [26].”
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“Plaques were matched between MRI and histology to determine that the smallest plaque that could be resolved in vivo had a diameter of 35 μm [15,16].”
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“Thalamic plaques are highly visible by standard Perl's (Prussian blue) staining [24].”
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“reported visualizing plaques in the ex vivo brain of APP/PS1 mice [10].”
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“The T1ρ-weighting generates sufficient plaque contrast, but the scan time was very long (3 hours) compared to the other techniques, and only a single slice was acquired.”
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“reported bright contrast detection of plaques using the CRAZED sequence [11].”
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- Authors
- Chamberlain, R., M. Wengenack, T., F. Poduslo, J., Garwood, M., & R. Jack, C.
- Affiliations
- University of Minnesota (US)
- Venue
- Current Medical Imaging Reviews
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-02-01
- Volume
- 7
- Issue
- 1
- Pages
- 3-7
- ISSN
- 1573-4056 (ISSN-L)
- PMC
- PMC3076792
- OpenAlex
- W2030950869
- Cited by
- 26
- References
- 20
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2020: 2 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Medical Imaging Formerly Current Medical Imaging Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (P30NS057091)
- National Center for Research Resources (P41RR008079)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid plaques, Alzheimer's disease, transgenic mouse model, magnetic resonance imaging, MR microscopy, APP/PS1 mice, MRI sequences, plaque detection, long-term monitoring
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