HTRF: A Technology Tailored for Drug Discovery - A Review of Theoretical Aspects and Recent Applications

Oncogenic kinase signalling.

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PROTEIN SERINE/THREONINE KINASES

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SIGNALLING BY RECEPTOR TYROSINE KINASES

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Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A 1 –A 2A Receptor Heteromers

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Principles and Biophysical Applications of Lanthanide-Based Probes

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Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

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Rare earth cryptates and homogeneous fluoroimmunoassays with human sera

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Probing molecular interactions with homogeneous techniques based on rare earth cryptates and fluorescence energy transfer

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The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

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Dopamine D2 receptors form higher order oligomers at physiological expression levels

Guo, W. X., Urizar, E., Králíková, M., Mobarec, J. C., Shi, L., Filizola, M., & Javitch, J. A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.153 · Cited by 334

Reversible Control of RNA Splicing by Photoswitchable Small Molecules

Zhang, L., Xie, X., Djoković, N., Nikolić, K., Kosenkov, D., Abendroth, F., & Vázquez, O. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c03275 · Cited by 15

Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery

Ding, Y., Xing, D., Fei, Y., Luo, S., & Lu, B. (2024) · Medicine Plus · doi:10.1016/j.medp.2023.100004 · Cited by 16

Using lanthanide-based resonance energy transfer for in vitro and in vivo studies of biological processes

Zherdeva, V. V., & Savitsky, A. P. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912130111 · Cited by 15

Flotation Immunoassay: Masking the Signal from Free Reporters in Sandwich Immunoassays

Chen, H., Hagström, A. E. V., Kim, J., Garvey, G., Paterson, A. S., Ruiz‐Ruiz, F., Raja, B., Strych, U., Rito‐Palomares, M., Kourentzi, K. D., et al. (2016) · Scientific Reports · doi:10.1038/srep24297 · Cited by 15

Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site

Meijer, F. A., van den Oetelaar, M. C. M., Doveston, R. G., Sampers, E. N. R., & Brunsveld, L. (2021) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.1c00029 · Cited by 15

Medicinal Chemistry Strategies for the Development of Inhibitors Disrupting β-Catenin’s Interactions with Its Nuclear Partners

Zhang, H., Liu, C., Zhu, D., Zhang, Q., & Li, J. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01016 · Cited by 15

Development of a CERT START Domain–Ceramide HTRF Binding Assay and Application to Pharmacological Studies and Screening

Fleury, L., Faux, C., Santos, C., Ballereau, S., Génisson, Y., & Ausseil, F. (2015) · SLAS DISCOVERY · doi:10.1177/1087057115573402 · Cited by 15

Time-Gated Luminescence Acquisition for Biochemical Sensing: miRNA Detection

García‐Fernández, E., Pernagallo, S., Gonzalez‐Vera, J. A., Ruedas-Rama, M. J., Díaz‐Mochon, J. J., & Orte, Á. (2019) · Springer series on fluorescence · doi:10.1007/4243_2018_4 · Cited by 15

A practical drug discovery project at the undergraduate level

Fray, M. J., Macdonald, S. J. F., Baldwin, I. R., Barton, N., Brown, J. A., Campbell, I. B., Churcher, I., Coe, D. M., Cooper, A. W. J., Craven, A. P., et al. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.09.004 · Cited by 15

Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening

Cuozzo, J. W., & Soutter, H. H. (2014) · SLAS DISCOVERY · doi:10.1177/1087057114520975 · Cited by 14

High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses

Cihlova, B., Hušková, A., Böserle, J., Nencka, R., Bouřa, E., & Šilhán, J. (2021) · Molecules · doi:10.3390/molecules26133792 · Cited by 14

Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines

Zessin, M., Meleshin, M., Hilscher, S., Schiene‐Fischer, C., Bařinka, C., Jung, M., & Schutkowski, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087416 · Cited by 14

Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay

Auriau, J., Roujeau, C., Belaid, Z., Oishi, A., Derviaux, C., Roux, T., Trinquet, E., Hermine, O., Jockers, R., & Dam, J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.014 · Cited by 14

Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I

Das, S., Harde, R. L., Shelke, D. E., Khairatkar-Joshi, N., Bajpai, M., Sapalya, R. S., Surve, H. V., Gudi, G. S., Pattem, R., Behera, D. B., et al. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.03.054 · Cited by 14

Micafungin: A promising inhibitor of UBE2M in cancer cell growth suppression

Mamun, M., Shuan, L., Zhao, L., Zhao, L., Li, Z., Shen, D., Zheng, Y., Zheng, Y., & Liu, H. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115732 · Cited by 13

Comparing Flow Cytometry QBeads PlexScreen Assays with Other Immunoassays for Determining Multiple Analytes

Ding, M., Cavallin, A., Hermansson, N.-O., Berntsson, P., Jinton, L., & Blomqvist, S. R. (2018) · SLAS DISCOVERY · doi:10.1177/2472555218771610 · Cited by 13

Exchangeable Self‐Assembled Lanthanide Antennas for PLIM Microscopy

Ruiz‐Arias, A., Fueyo‐González, F., Izquierdo‐García, C., Navarro, A., Gutiérrez‐Rodríguez, M., Herranz, R., Burgio, C., Reinoso, A., Cuerva, J. M., Orte, Á., et al. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202314595 · Cited by 13

Detection of NAD(P)H-dependent enzyme activity by time-domain ratiometry of terbium luminescence

Terai, T., Ito, H., Hanaoka, K., Komatsu, T., Ueno, T., Nagano, T., & Urano, Y. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.03.038 · Cited by 13

Development of inverse electron demand Diels–Alder ligation and TR-FRET assays for the determination of ligand–protein target occupancy in live cells

Marjanovic, J., Baranczak, A., Marin, V. L., Stöckmann, H., Richardson, P. L., & Vasudevan, A. (2017) · MedChemComm · doi:10.1039/c7md00049a · Cited by 13

Pentacyclic Triterpenes from Cecropia telenitida Can Function as Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Mosquera, C., Panay, A. J., & Montoya, G. (2018) · Molecules · doi:10.3390/molecules23061444 · Cited by 13

Time-Resolved Förster Resonance Energy Transfer-Based Technologies to Investigate G Protein-Coupled Receptor Machinery

Scholler, P., Zwier, J. M., Trinquet, E., Rondard, P., Pin, J., Prézeau, L., & Kniazeff, J. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386932-6.00007-7 · Cited by 13

A Small Molecule Inhibitor of Pot1 Binding to Telomeric DNA

Altschuler, S. E., Croy, J. E., & Wuttke, D. S. (2012) · Biochemistry · doi:10.1021/bi300365k · Cited by 13

Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8

Merriman, C., Li, H., Li, H., & Fu, D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005136 · Cited by 12

Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)–based fluorescence quencher

Zessin, M., Meleshin, M., Simic, Z., Kalbas, D., Arbach, M., Gebhardt, P., Melesina, J., Liebscher, S., Bordusa, F., Sippl, W., et al. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105425 · Cited by 12

iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells

Bouguenina, H., Nicolaou, S., Bihan, Y. L., Bowling, E. A., Calderon, C., Caldwell, J., Harrington, B., Hayes, A., McAndrew, C., Mitsopoulos, C., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107059 · Cited by 12

Leveraging Rational Protein Engineering to Improve mRNA Therapeutics

Farelli, J. D., Asrani, K. H., Isaacs, C., Debear, J. S., Stahley, M. R., Shah, A., Lasaro, M. A., Cheng, C. J., & Subramanian, R. R. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2017.0697 · Cited by 12

Review of NEDDylation inhibition activity detection methods

Wang, S., Liu, X., Liu, Y., Zhang, H., Zhang, Y., Chong, L., Song, J., Niu, J.-B., & Zhang, S. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115875 · Cited by 12

Highly luminescent Tb(III) macrocyclic complex based on a DO3A hosting unit and an appended carboxylated N,C-pyrazolylpyridine antenna

Nasso, I., Geum, N., Bechara, G., Mestre-Voegtlé, B., Galaup, C., & Picard, C. (2013) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2013.10.005 · Cited by 11

Use of fluorescence lifetime technology to provide efficient protection from false hits in screening applications

Gakamsky, D. M., Dennis, R. B., & Smith, S. D. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.10.017 · Cited by 11

Tetracycline-Based System for Controlled Inducible Expression of Group III Metabotropic Glutamate Receptors

Chruścicka, B., Burnat, G., Brański, P., Chorobik, P., Lenda, T., Marciniak, M., & Pilc, A. (2014) · SLAS DISCOVERY · doi:10.1177/1087057114559183 · Cited by 11

Toward universal protein post-translational modification detection in high throughput format

Härmä, H., Tong-Ochoa, N., van Adrichem, A. J., Jelesarov, I., Wennerberg, K., & Kopra, K. (2018) · Chemical Communications · doi:10.1039/c7cc09575a · Cited by 11

Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells

Deng, Y., Moo, E. V., Almeria, C. V. P., Gentry, P. R., Vedel, L., Mathiesen, J. M., & Bräuner‐Osborne, H. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13738 · Cited by 11

Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part II

Das, S., Shelke, D. E., Harde, R. L., Avhad, V. B., Khairatkar-Joshi, N., Gullapalli, S., Gupta, P. K., Gandhi, M. N., Bhateja, D., Bajpai, M., et al. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.06.028 · Cited by 11

Fluorescence Lifetime–Based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro

Boettcher, A., Gradoux, N., Lorthiois, E., Brandl, T., Orain, D., Schiering, N., Cumin, F., Woelcke, J., & Hassiepen, U. (2014) · SLAS DISCOVERY · doi:10.1177/1087057114521295 · Cited by 11

Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

Frandsen, I. O., Boesgaard, M. W., Fidom, K., Hauser, A. S., Ísberg, V., Bräuner‐Osborne, H., Wellendorph, P., & Gloriam, D. E. I. (2017) · Scientific Reports · doi:10.1038/s41598-017-05058-w · Cited by 11

Utilizing a Simple Method for Stoichiometric Protein Labeling to Quantify Antibody Blockade

Ohana, R. F., Hurst, R., Rosenblatt, M., Levin, S., Machleidt, T., Kirkland, T. A., Encell, L. P., Robers, M. B., & Wood, K. V. (2019) · Scientific Reports · doi:10.1038/s41598-019-43469-z · Cited by 11

Miniaturization of High-Throughput Epigenetic Methyltransferase Assays with Acoustic Liquid Handling

Edwards, B., Lesnick, J., Wang, J., Tang, N. T., & Peters, C. (2015) · SLAS TECHNOLOGY · doi:10.1177/2211068215610861 · Cited by 11

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach

Hoffer, L., Garcia, M., Leblanc, R., Feracci, M., Betzi, S., Yaala, K. B., Daulat, A. M., Zimmermann, P., Roche, P., Barral, K., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01569 · Cited by 10

(±)-Bicoryanhunine A, dimeric benzylisoquinoline alkaloid atropo-enantiomers from Corydalis yanhusuo

Xiao, B.-B., Xia, G., Wang, L., Qiu, B.-L., Xia, H., Zhong, W.-C., Tian, G.-H., & Lin, S. H. (2020) · Tetrahedron Letters · doi:10.1016/j.tetlet.2020.151890 · Cited by 10

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R)

Mach, L., Omran, A., Bouma, J., Radetzki, S., Sykes, D. A., Guba, W., Li, X., Höffelmeyer, C., Hentsch, A., Gazzi, T., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00465 · Cited by 10

4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis

Granel, J., Lemoine, R., Morello, E., Gallais, Y., Mariot, J., Drapeau, M., Musnier, A., Anne Poupon, B., Pugnière, M., Seren, S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573040 · Cited by 10

SARS-CoV-2 Nucleocapsid Protein TR-FRET Assay Amenable to High Throughput Screening

Gorshkov, K., Vasquez, D. M., Chiem, K., Ye, C., Tran, B. N., de la Torre, J. C., Moran, T. M., Chen, C. Z., Martínez‐Sobrido, L., & Zheng, W. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00182 · Cited by 10

Multiparametric Homogeneous Method for Identification of Ligand Binding to G Protein-Coupled Receptors: Receptor–Ligand Binding and β-Arrestin Assay

Kopra, K., Kainulainen, M. H., Mikkonen, P., Rozwandowicz-Jansen, A., Hanninen, P. E., & Härmä, H. (2013) · Analytical Chemistry · doi:10.1021/ac303215r · Cited by 10

Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum

Tapia-Alveal, C., Olsen, T. R., & Worgall, T. S. (2020) · Communications Biology · doi:10.1038/s42003-020-01515-x · Cited by 10

Peptide foldamer-based inhibitors of the SARS-CoV-2 S protein–human ACE2 interaction

Marković, V. R., Shaik, J. B., Ożga, K., Ciesiołkiewicz, A., Pérez, J. L., Rudzińska‐Szostak, E., & Berlicki, Ł. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2244693 · Cited by 9

Identification and characterization of TYK2 pseudokinase domain stabilizers that allosterically inhibit TYK2 signaling

Locke, G. A., Muckelbauer, J. K., Tokarski, J. S., Barbieri, C. M., Belić, S., Falk, B. T., Tredup, J. A., & Wang, Y.-K. (2022) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2022.03.051 · Cited by 9

Identification of Novel Dopamine D2 Receptor Ligands—A Combined In Silico/In Vitro Approach

Zell, L., Lainer, C., Kollár, J., Temml, V., & Schuster, D. (2022) · Molecules · doi:10.3390/molecules27144435 · Cited by 9

Progress on biphenyl derivatives as PD-1/PD-L1 inhibitors

Wang, S., Wang, Y., & Yan, H. (2023) · Medicinal Chemistry Research · doi:10.1007/s00044-023-03127-6 · Cited by 10

The green tea polyphenol (2)-epigallocatechin-3-gallate (EGCG) is not a β-secretase inhibitor

Cheng, X., Zhou, J.-W., Zhou, Y., Cheng, J., Yang, R., Zhou, W., Zhang, Y., & Yun, L. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.12.034 · Cited by 9

In vitro Screening Systems

Blass, B. E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411508-8.00004-9 · Cited by 9

Approaches to Assess Biased Signaling at the CB1R Receptor

Laprairie, R. B., Stahl, E. L., & Bohn, L. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.06.031 · Cited by 9

In Situ Ligation of High‐ and Low‐Affinity Ligands to Cell Surface Receptors Enables Highly Selective Recognition

Taichi, M., Nomura, S., Nakase, I., Imamaki, R., Kizuka, Y., Ota, F., Dohmae, N., Kitazume, S., Taniguchi, N., & Tanaka, K. (2017) · Advanced Science · doi:10.1002/advs.201700147 · Cited by 9

Characterization of association of human mitochondrial lysyl-tRNA synthetase with HIV-1 Pol and tRNA3Lys

Khoder‐Agha, F., Dias, J., Comisso, M., & Mirande, M. (2018) · BMC Biochemistry · doi:10.1186/s12858-018-0092-x · Cited by 9

Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor

Ayukawa, K., Suzuki, C., Ogasawara, H., Kinoshita, T., Furuno, M., & Suzuki, G. (2019) · SLAS DISCOVERY · doi:10.1177/2472555219875101 · Cited by 9

The PopN Gate-keeper Complex Acts on the ATPase PscN to Regulate the T3SS Secretion Switch from Early to Middle Substrates in Pseudomonas aeruginosa

Ngo, T.-D., Perdu, C., Jneid, B., Ragno, M., Ducassou, J. N., Kraut, A., Couté, Y., Stopford, C. M., Attrée, I., Rietsch, A., et al. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.10.024 · Cited by 9

Design of novel tripyridinophane-based Eu( iii ) complexes as efficient luminescent labels for bioassay applications

Leygue, N., Picard, C., Faure, P., Bourrier, E., Lamarque, L., Zwier, J. M., & Galaup, C. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob02092g · Cited by 9

Site-Specific Protein Labeling in the Pharmaceutical Industry: Experiences from Novartis Drug Discovery

Leder, L. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-2272-7_2 · Cited by 9

Mammalian Cell Line Selection Strategies for High-Producers

Kuystermans, D., & Al‐Rubeai, M. (2014) · Cell engineering · doi:10.1007/978-3-319-10320-4_11 · Cited by 9

Identification of catalytic and non‐catalytic activity inhibitors against PRC2‐EZH2 complex through multiple high‐throughput screening campaigns

Zhou, Y., Du, D., Wang, J., Cai, X., Deng, A. X., Nosjean, O., Boutin, J. A., Renard, P., Yang, D., Luo, C., et al. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13702 · Cited by 9

Design, synthesis and biological evaluation of 2-methyl-(1,1′-biphenyl)-pyrimidine conjugates

Chen, A., Wu, D. L., Shi, J., Narva, S., Zhao, X., Wu, Y.-L., & Zhang, W. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127328 · Cited by 9

Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein

DiMuzio, J. M., Heimbach, B. C., Howanski, R. J., Dowling, J. P., Patel, N. B., Henriquez, N., Nicolescu, C., Nath, M., Polley, A. M., Bingaman, J. L., et al. (2021) · Vaccine X · doi:10.1016/j.jvacx.2021.100098 · Cited by 9

Development of a homogeneous time-resolved FRET (HTRF) assay for the quantification of Shiga toxin 2 produced by E. coli

Nakamura, K., Tokuda, C., Arimitsu, H., Etoh, Y., Hamasaki, M., Deguchi, Y., Taniguchi, I., Gotoh, Y., Ogura, Y., & Hayashi, T. (2021) · PeerJ · doi:10.7717/peerj.11871 · Cited by 8

Drug discovery through biophysical techniques: Methods and applications

Zhou, Y., Hu, H., Huang, Q., Tang, Y., & Liu, Y. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108947 · Cited by 9

Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer

Bua, S., Nocentini, A., Bonardi, A., Palma, G., Ciampi, G., Giliberti, A., Iannelli, F., Bruzzese, F., Supuran, C. T., & de Nigris, F. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01563 · Cited by 8

Screening Strategies for the Discovery of Ion Channel Monoclonal Antibodies

Colley, C. S., England, E., Linley, J. E., & Wilkinson, T. C. I. (2018) · Current Protocols in Pharmacology · doi:10.1002/cpph.44 · Cited by 8

Guidelines for HTRF technology in EGFR kinase assay

Liang, Y., & Zhang, T. (2022) · eFood · doi:10.1002/efd2.26 · Cited by 8

Functional Investigation of Melatonin Receptor Activation by Homogenous cAMP Assay

Cecon, E., Guillaume, J., & Jockers, R. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2593-4_22 · Cited by 8

Exiting the tunnel of uncertainty: crystal soak to validated hit

Martin, M. P., & Noble, M. E. M. (2022) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798322009986 · Cited by 9

Effects of 6-Aminonicotinic Acid Esters on the Reprogrammed Epigenetic State of Distant Metastatic Pancreatic Carcinoma

Gao, R.-D., Maeda, M., Tallon, C., Feinberg, A. P., Slusher, B. S., & Tsukamoto, T. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.2c00404 · Cited by 8

An Adaptable Luminescence Resonance Energy Transfer Assay for Measuring and Screening Protein–Protein Interactions and their Inhibition.

Yapici, E., Reddy, D. R., & Miller, L. W. (2012) · ChemBioChem · doi:10.1002/cbic.201100710 · Cited by 8

Homogeneous agglutination assay based on micro-chip sheathless flow cytometry

Ma, Z., Zhang, P., Cheng, Y., Xie, S., Zhang, S., & Ye, X. (2015) · Biomicrofluidics · doi:10.1063/1.4936926 · Cited by 8

Manipulation and Measurement of AMPK Activity in Pancreatic Islets

Martínez-Sánchez, A., Nguyen‐Tu, M., Leclerc, I., & Rutter, G. A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7598-3_26 · Cited by 8

An innovative kinome platform to accelerate small-molecule inhibitor discovery and optimization from hits to leads

Chaudhry, C., Tebben, A. J., Tokarski, J. S., Borzilleri, R. M., Pitts, W. J., Lippy, J., & Zhang, L. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.01.018 · Cited by 8

Discovery of 4‐(Piperazin‐1‐yl)‐7H‐pyrrolo[2,3‐d]pyrimidine Derivatives as Akt Inhibitors

Liu, Y., Yin, Y., Zhang, J., Nomie, K. J., Zhang, L., Yang, D., Wang, M. L., & Zhao, G. (2016) · Archiv der Pharmazie · doi:10.1002/ardp.201500427 · Cited by 8

Drug Discovery Methods

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Discovery of novel benzosultam CRBN ligands

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