Pathogen recognition by innate immunity and its signaling

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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A Toll-like receptor recognizes bacterial DNA

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680

Expresión del receptor tipo-Toll 4 en la inflamación alérgica de niños asmáticos-obesos

Pacheco-Martínez, M. M., Saucedo-Ramírez, O. J., Navarro, B. E. D. R., del Río-Chivardí, J. M., Cruz, M., Pérez‐Figueroa, G. E., Huerta‐Yépez, S., & Maldonado‐Bernal, C. (2011) · Boletín Médico del Hospital Infantil de México · Cited by 2

Development of Allele-Specific Primer PCR for a Swine TLR2 SNP and Comparison of the Frequency among Several Pig Breeds of Japan and the Czech Republic

Muneta, Y., Minagawa, Y., Kusumoto, M., Shinkai, H., Uenishi, H., & Šplı́chal, I. (2011) · Journal of Veterinary Medical Science · doi:10.1292/jvms.11-0304 · Cited by 2

Modulation of Mucosal Antiviral Immune Response at the Female Genital Tract by Immunobiotic Lactic Acid Bacteria

Guadalupe, M. (2013) · Journal of Immunological Techniques in Infectious Diseases · doi:10.4172/2329-9541.1000120 · Cited by 1

Suppression of Monkeypox Virus by Downregulation of Fatty Acid Synthase and Upregulation of Cholesterol‐25 Hydroxylase

Aliyari, S. R., Shanaa, J., Yu, D. S., Yamamoto, M., Bateman, K. N., Wang, L., Jung, M. E., & Cheng, G. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70403 · Cited by 1

Understanding Sustainable Agriculture

Khan, N. F., & Rehman, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-83066-3_1 · Cited by 1

Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context

Li, H., Li, X., Zhu, Y., Xu, J., Zhao, Q., Chen, X., Zhang, Y., Zhao, L., Chen, Y., Weng, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1671434 · Cited by 1

Skin Diseases in Primary Immunodeficiencies

Vincent, S. F., Casady, M., Chacon, A. H., & Gaspari, A. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-68790-2_2 · Cited by 1

Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos.

Nassar, R. S. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.87.2013.tde-06112013-100747 · Cited by 1

Innate patterning of the immune response to Marek's disease virus (MDV) during pathogenesis and vaccination

Katneni, U. (2024) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/35gq-m967 · Cited by 1

Humoral response towards high density lipoprotein : a new mechanism for atherogenesis

Batuca, J. R. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1

The role of APOBEC3G in acute and early HIV-1 subtype C infection.

Reddy, K. (2014) · ResearchSpace (University of KwaZulu-Natal)

Lokale Stimulation des pulmonalen Immunsystems mit dem TLR2/6-Agonisten MALP-2 und deren Auswirkung auf pulmonale Melanommetastasierung im Maus-Modell

Schill, T. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4578

Perfil de citocinas produzidas por macrófagos na presença de intimina e bundlina (BfpA) de Escherichia coli enteropatogênica

Mourão, D. B. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.9.2012.tde-23082013-103356

Innate immunity mediated by the flagellin receptor FLS2 in Arabidopsis and tomato : a molecular approach to characterize ligand binding and function, using receptor chimeras

Bittel, P. (2010) · edoc (University of Basel) · doi:10.5451/unibas-005584698

Avaliação da atividade imunomoduladora da microplusina sobre macrófagos murinos in vitro.

Gerardi, L. A. (2010) · doi:10.11606/d.87.2010.tde-01122010-110647

Sterol biosynthesis pathway is part of the interferon host defence response

Blanc, M. (2011) · ERA

Midkine - a host defence protein

Nordin, S. L. (2013) · Lund University Publications (Lund University)

Immunity in Caenorhabditis elegans : A Tale of Two Transcription Factors

TeKippe, M. (2009) · DukeSpace (Duke University)

Infection of differentiated epithelial cells by viruses of the bovine respiratory disease complex

Kirchhoff, J. (2014)

The Innate Immunity

Sun, H., Sun, C., & Tian, Z. (2016) · Springer eBooks · doi:10.1007/978-94-024-0902-4_2

Immune-Mediated Accelerated Atherosclerosis

Gruber, S., Tsiantoulas, D., & Binder, C. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803267-1.00004-1

Papel dos receptores intracelulares NOD1 e NOD2 na gênese da dor neuropática

Cecilia, F. V. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-01022016-111957

A ativação do receptor AIM2 na mucosa intestinal confere proteção ao diabetes tipo 1 experimental

Leite, J. A. (2019) · doi:10.11606/d.17.2019.tde-15102018-110809

Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension

Wild, J., & Wenzel, P. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02019-1

Papel de las vesículas extracelulares en la propagación y mantenimiento de la neuroinflamación inducida por el consumo de alcohol en la adolescencia

Cabanes, F. I. (2021) · RiuNet (Universitat Politècnica de València) · doi:10.4995/thesis/10251/174214

Inhibition of the TLR4/NF-κB/TNF-α axis by TAK-242 or PDTC reduces central nervous system inflammation to alleviate lipopolysaccharide induced sickness behaviors in micePreprint

Tuo, P., Wang, Y., Chen, W., Xie, J., Jie, Y., Liu, J., Liu, X., Zhang, W., & Wang, S. (2022) · Research Square · doi:10.21203/rs.3.rs-1471486/v1

Faculty Opinions recommendation of TIP60 represses activation of endogenous retroviral elements.

Chiang, C. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733701718.793548911

O papel de Gasdermina-D e da morte celular na resposta imune contra Legionella longbeachae em modelo murino da doença dos legionários

Oliveira, S. D. S. (2022) · doi:10.11606/d.17.2022.tde-08082022-085914

The TRK-fused gene negatively regulates interferon signaling by inhibiting TBK1 phosphorylation during PPMV-1 infection

Tian, Y., Xue, R., Yu, C., Liu, L., Chen, S., & Lv, J. (2023) · Acta Virologica · doi:10.3389/av.2023.11607

Innate Immunity and Inflammation

McKarns, S. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.50005-9

Additional file 1 of Factor of time in dendritic cell (DC) maturation: short-term activation of DCs significantly improves type 1 cytokine production and T cell responses

Poženel, P., Zajc, K., & Švajger, U. (2024) · Figshare · doi:10.6084/m9.figshare.25989215

Probiotiques, prébiotiques, synbiotiques et prévention des maladies inflammatoires chroniques de l'intestin : proposition d'un crible de sélection rationnel in vitro

Grimoud, J. (2010) · theses.fr (ABES) · doi:10.70675/080ce639z39cfz4cc1z96dezbd81d07f2bff

Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition

Mi, Y., Wang, R., Qian, J., Liu, Z., Li, Y., Fan, H., Wang, L., Kuai, H., Xiong, F., Wang, H., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158147

Polymorphisme rs16969968 de la sous-unité alpha-5 des récepteurs nicotiniques et Broncho-Pneumopathie Chronique Obstructive (BPCO)

Routhier, J. (2017) · theses.fr (ABES) · doi:10.70675/4882b201zacc2z486dzb532ze2e3380dc642

Cellular endogenous double-stranded RNA: From pathophysiology to therapeutic implications

Xin, X., Weng, Y., Gu, J., Wang, J., Liu, J., Zhao, T., & Jin, Z. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102262

Immunological Signatures of Viral Infections

Ramavat, A., Chatterjee, A., Kaushik, S., & Gaur, P. (2026) · Springer eBooks · doi:10.1007/978-981-95-2300-9_26-1

The TLR4/MyD88 axis in cancer: Divergent and convergent roles of NF-κB and NLRP3 inflammasome activation and therapeutic opportunities

Zaeifi, D., Jamialahmadi, K., & Karimi, G. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.109645

BindingDB Entry 50008055: Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model.

BindingDB (2021) · UC San Diego · doi:10.7270/q2np27rx

BindingDB Entry 50039586: Identification of Inhibitors of NOD1-Induced Nuclear Factor-¿B Activation.

BindingDB (2013) · UC San Diego · doi:10.7270/q2h9966z

BindingDB Entry 50033093: Structure-activity relationships in nucleotide oligomerization domain 1 (Nod1) agonistic¿-glutamyldiaminopimelic acid derivatives.

BindingDB (2011) · UC San Diego · doi:10.7270/q2pv6kpq

Regulation of Interferon Stimulated Genes in West Nile Virus Infected Mouse Embryofibroblasts

Pulit-Penaloza, J. A. (2022) · Digital Archive @ GSU · doi:10.57709/2435185

Genome-wide transcriptome analysis of dendritic cells in a model of acute and persistent infection

Filkor, K. (2013) · doi:10.14232/phd.2005

Review Pathogen recognition by innate immunity and its signaling By Shizuo AKIRA1,2;y

Kishimoto, C. T. (2016)

The Instructive Role of Innate Immunity in the Acquired Immune Response

Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,711

Innate immunity and the biological relevance of the acquired immune response

Fearon, D. T. (1999) · QJM · doi:10.1093/qjmed/92.5.235 · Cited by 16

NF-κB signaling pathways in mammalian and insect innate immunityPreprint

Silverman, N. S., & Maniatis, T. (2001) · Genes & Development · doi:10.1101/gad.909001 · Cited by 904

A new era for innate immunity

Vega, M. T. M., & Vega, M. T. M. (2008) · Allergologia et Immunopathologia · doi:10.1016/s0301-0546(08)72542-4 · Cited by 10