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Pathogen recognition by innate immunity and its signaling
Open accessAbstract
Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.
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“Airway epithelial cells rapidly recognize pathogens through pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and intracellular viral sensors (3) (Fig. 2).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [3]
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Cites
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Metadata
- Authors
- AKIRA, S.
- Affiliations
- Immunology Frontier Research Center, The University of Osaka (JP)
- Corresponding author
- AKIRA, Shizuo
- ORCID
- AKIRA, Shizuo
- Venue
- Proceedings of the Japan Academy, Series B
- Publisher
- Japan Academy
- Published
- 2009
- Volume
- 85
- Issue
- 4
- Pages
- 143-156
- ISSN
- 0386-2208 (ISSN-L)
- 1349-2896
- PMC
- PMC3524297
- OpenAlex
- W2085055906
- Cited by
- 240
- References
- 56
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 14 · 2019: 17 · 2018: 15 · 2017: 20 · 2016: 17 · 2015: 17 · 2014: 23 · 2013: 10 · 2012: 11
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the Japan Academy Series B (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- pathogen recognition, innate immunity, adaptive immunity, infection, immune disorders, allergy, cancer
- MeSH terms
- Animals, Antibody Formation, Autoimmune Diseases, Bacterial Infections, Humans, Hypersensitivity, Immunity, Cellular, Immunity, Innate, Neoplasms, Virus Diseases, Signal Transduction, Cytokines, Antigen Presentation, Toll-Like Receptors, Host-Pathogen Interactions
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