Mapping Technologies, Support Functions, Evaluation Outcomes, and Safety Governance Related to Conversational AI Agents for Psychological Support of Patients With Cancer: Scoping Review
Open accessPublished version of a preprint
Abstract
Background: Psychological distress and unmet psychosocial needs are common across the cancer continuum. Conversational AI agents may offer scalable support, but their technologies, support functions, evaluation approaches, and safety governance remain fragmented. Objective: This review aimed to map the technologies, psychological support functions, evaluation outcomes, and safety governance of conversational AI used by patients with cancer and cancer survivors. Methods: We conducted a scoping review following Joanna Briggs Institute (JBI) methodology and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews). Thirteen databases and additional registers were searched through May 5, 2026. Eligible reports examined conversational agents in real or simulated patient-facing oncology contexts with explicit psychological or psychosocial relevance. We summarized system forms and support functions by project and other characteristics by report. No formal critical appraisal was undertaken. Results: We included 24 reports representing 25 study units and 23 underlying projects. Large language model (LLM) or generative AI systems accounted for 39.1% (9/23) of projects. Information or education (23/23, 100%) and symptom or self-management support (n=20, 87%) were the most frequently mapped functions, although these counts included delivered, planned, simulated, co-designed, and participant-reported functions. Structured psychological or behavioral components were delivered in 21.7% (5/23) of projects. An explicit theoretical or conceptual framework was reported in 25% (6/24) of reports. Reports or plans to assess acceptability or user experience (17/24, 70.8%) and engagement (13/24, 54.2%) were more common than reports or plans to assess psychosocial clinical outcomes (8/24, 33.3%) or safety and adverse events (4/24, 16.7%). Human or expert oversight was reported in 62.5% (15/24) of reports, crisis escalation or referral in 33.3% (8/24) of reports, and user-facing AI identity disclosure in 12.5% (3/24) of reports. Conclusions: Conversational AI research in psycho-oncology spans heterogeneous technologies and stages of development. Clinical and safety evaluation, theoretical foundations, population representation, and oversight responsibilities remain incompletely reported. These findings represent a map of reporting patterns and do not establish effectiveness or safety. Future studies should evaluate psychosocial benefit and safety prospectively and define professional oversight and referral responsibilities. Trial Registration: OSF Registries UM65W; https://osf.io/um65w
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Written from the paper’s full text.
TL;DR
This scoping review mapped 24 reports (25 study units, 23 projects) on conversational AI for psychological support in cancer, finding heterogeneous technologies and functions, with information/education and symptom/self-management most commonly mapped and clinical/safety outcomes less often reported. It concludes that the evidence map does not establish effectiveness or safety and calls for prospective evaluation and clearer oversight and referral responsibilities.
Key findings
- Across 23 projects, information or education was mapped in 23/23 (100%) and symptom or self-management support in 20/23 (87%); structured psychological or behavioral intervention was mapped in 7/23 (30.4%) with any evidence, but delivered-only sensitivity analysis was 5/23 (21.7%).
- LLM or generative AI systems accounted for 9/23 (39.1%) of projects; rule-, knowledge-, or retrieval-based text agents 6/23 (26.1%); voice assistants or smart speakers 3/23 (13%); social robot or embodied agent 1/23 (4.3%); concept or nondeployed systems 3/23 (13%); multimodal monitoring platform and chatbot 1/23 (4.3%).
- Evaluation reporting favored acceptability, satisfaction, or user experience (17/24, 70.8%) and engagement, use, or adherence (13/24, 54.2%) over psychosocial clinical outcomes (8/24, 33.3%) and safety or adverse events (4/24, 16.7%); an explicit theoretical or conceptual framework was reported in 6/24 (25%) reports, while 12/24 (50%) reported no explicit theoretical basis.
- Safety governance reporting included ethics-related procedures (22/24, 91.7%), human or expert oversight (15/24, 62.5%), privacy or data protection (13/24, 54.2%), accuracy or hallucination management (12/24, 50%), crisis escalation/referral/high-risk response (8/24, 33.3%), user-facing AI identity disclosure (3/24, 12.5%), explicit role boundaries (6/24, 25%), and nonreplacement statements (5/24, 20.8%).
Methods
- Scoping review following Joanna Briggs Institute methodology and PRISMA-ScR, with a protocol prospectively registered on OSF (UM65W); 13 databases plus additional registers were searched through May 5, 2026, with no language restrictions and no formal critical appraisal.
- Eligible reports involved patients with cancer or cancer survivors, or explicitly patient-facing simulated oncology scenarios, and examined AI-supported interactive text, voice, or multimodal dialogue with explicit psychological, emotional, psychosocial, coping, survivorship, supportive care, or quality-of-life relevance.
- Two reviewers independently screened and charted data using a standardized Excel form; discrepancies were resolved by discussion or a third reviewer. Descriptive numerical summaries and narrative synthesis were used, with reports as the unit for publication, design, theory, outcomes, population, and governance characteristics, and projects as the unit for system forms and support functions; support, outcome, and governance categories were non–mutually exclusive.
Limitations
- Paper-stated: the search ended May 5, 2026, and may not capture later publications, commercial systems, or nonindexed work; included designs ranged from protocols and simulated evaluations to trials, so mapped projects do not represent equivalent levels of clinical evidence; without formal critical appraisal or meta-analysis, the review cannot establish effectiveness, safety, or certainty of evidence.
- Paper-stated: charting relied on explicit reporting and may underestimate undocumented theoretical, technical, population, or governance features; incomplete project identifiers may affect report linkage; general-purpose LLMs were eligible only within studied oncology support contexts, so findings cannot characterize unstudied independent everyday use by people with cancer.
- Evident from the text: the reported frequencies describe reporting patterns and include delivered, planned, simulated, co-designed, and participant-reported functions, so they should not be read as measures of study quality, effectiveness, safety, or clinical readiness; population and equity-related reporting was insufficient to determine how representative the evidence base is.
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Claims the paper makes
19 of 47 cited sources checked · 13 supported · 0 flagged · accuracy not yet measured
- Premisecitation§ Introduction
Individual studies have investigated generative AI support for pediatric and young adult patients.
“generative AI support for pediatric and young adult patients”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [11] source
- Premisecitation§ Introduction
Digital interventions may improve mental health outcomes among patients with cancer and cancer survivors.
“Digital interventions may improve mental health outcomes among patients with cancer and cancer survivors”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [5] source
- Findingown data§ Abstract
Reports or plans to assess safety and adverse events were present in 4/24 (16.7%) of reports.
“Reports or plans to assess acceptability or user experience (17/24, 70.8%) and engagement (13/24, 54.2%) were more common than reports or plans to assess psychosocial clinical outcomes (8/24, 33.3%) or safety and adverse events (4/24, 16.7%).”
Quote in the paperSubstantial claim - Findingown data§ Abstract
User-facing AI identity disclosure was reported in 12.5% (3/24) of reports.
“Human or expert oversight was reported in 62.5% (15/24) of reports, crisis escalation or referral in 33.3% (8/24) of reports, and user-facing AI identity disclosure in 12.5% (3/24) of reports.”
Quote in the paperNot a substantial claim - Findingown data§ Results
Ultimately, 24 reports (31.6% of those assessed as full texts) were included.
“Ultimately, 24 reports (31.6% of those assessed as full texts) were included, representing 25 operational study units nested within 23 underlying AI projects.”
Quote in the paperNot a substantial claim
- Findingown data§ Results
The 24 included reports represented 25 operational study units nested within 23 underlying AI projects.
“Ultimately, 24 reports (31.6% of those assessed as full texts) were included, representing 25 operational study units nested within 23 underlying AI projects.”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Structured psychological or behavioral components were delivered in 21.7% (5/23) of projects.
“Structured psychological or behavioral components were delivered in 21.7% (5/23) of projects.”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Human or expert oversight was reported in 62.5% (15/24) of reports.
“Human or expert oversight was reported in 62.5% (15/24) of reports, crisis escalation or referral in 33.3% (8/24) of reports, and user-facing AI identity disclosure in 12.5% (3/24) of reports.”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Reports or plans to assess psychosocial clinical outcomes were present in 8/24 (33.3%) of reports.
“Reports or plans to assess acceptability or user experience (17/24, 70.8%) and engagement (13/24, 54.2%) were more common than reports or plans to assess psychosocial clinical outcomes (8/24, 33.3%) or safety and adverse events (4/24, 16.7%).”
Quote in the paperSubstantial claim - Findingown data§ Abstract
An explicit theoretical or conceptual framework was reported in 25% (6/24) of reports.
“An explicit theoretical or conceptual framework was reported in 25% (6/24) of reports.”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Reports or plans to assess engagement were present in 13/24 (54.2%) of reports.
“Reports or plans to assess acceptability or user experience (17/24, 70.8%) and engagement (13/24, 54.2%) were more common than reports or plans to assess psychosocial clinical outcomes (8/24, 33.3%) or safety and adverse events (4/24, 16.7%).”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Symptom or self-management support was mapped as a support function in 20 projects (87%).
“Information or education (23/23, 100%) and symptom or self-management support (n=20, 87%) were the most frequently mapped functions, although these counts included delivered, planned, simulated, co-designed, and participant-reported functions.”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Large language model (LLM) or generative AI systems accounted for 39.1% (9/23) of projects.
“Large language model (LLM) or generative AI systems accounted for 39.1% (9/23) of projects.”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Reports or plans to assess acceptability or user experience were present in 17/24 (70.8%) of reports.
“Reports or plans to assess acceptability or user experience (17/24, 70.8%) and engagement (13/24, 54.2%) were more common than reports or plans to assess psychosocial clinical outcomes (8/24, 33.3%) or safety and adverse events (4/24, 16.7%).”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Information or education was mapped as a support function in 23/23 (100%) of projects.
“Information or education (23/23, 100%) and symptom or self-management support (n=20, 87%) were the most frequently mapped functions, although these counts included delivered, planned, simulated, co-designed, and participant-reported functions.”
Quote in the paperNot a substantial claim - Findingown data§ Abstract
Crisis escalation or referral was reported in 33.3% (8/24) of reports.
“Human or expert oversight was reported in 62.5% (15/24) of reports, crisis escalation or referral in 33.3% (8/24) of reports, and user-facing AI identity disclosure in 12.5% (3/24) of reports.”
Quote in the paperNot a substantial claim - Findingown data§ Results
Therapeutic models or components without an explicit theory-guided framework were reported in 6 of 24 reports (25%).
“Therapeutic models or components without an explicit theory-guided framework 6 (25)”
Quote in the paperNot a substantial claim - Findingown data§ Results
Adults aged 65 years or older were represented in 7 of 24 reports (29.2%).
“adults aged ≥65 years in 7 (29.2%),”
Quote in the paperNot a substantial claim - Findingown data§ Results
In a delivered-only sensitivity analysis, the corresponding support-function frequencies were 13 (56.5%), 12 (52.2%), 6 (26.1%), 5 (21.7%), 7 (30.4%), 5 (21.7%), and 1 (4.3%).
“In a delivered-only sensitivity analysis, the corresponding frequencies were 13 (56.5%), 12 (52.2%), 6 (26.1%), 5 (21.7%), 7 (30.4%), 5 (21.7%), and 1 (4.3%), respectively.”
Quote in the paperNot a substantial claim - Findingown data§ Results
Information or education was mapped as a psychological support function in 23 of 23 projects (100%).
“Information or education 23 (100)”
- Also stated in: § Results · plain
“Across the 23 projects, information or education was mapped in 23 (100%),”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
AI response quality, factuality, empathy, readability, inclusiveness, bias, hallucination, or contextual error outcomes were reported in 7 of 24 reports (29.2%).
“AI response quality, factuality, empathy, readability, inclusiveness, bias, hallucination, or contextual error outcomes were reported in 29.2% (7/24) of reports.”
Quote in the paperNot a substantial claim - Findingown data§ Results
Navigation or resource recommendation was mapped as a psychological support function in 14 of 23 projects (60.9%).
“Navigation or resource recommendation 14 (60.9)”
- Also stated in: § Results · plain
“navigation or resource recommendation in 14 (60.9%),”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
Engagement, use, or adherence was reported in 13 of 24 reports (54.2%).
“followed by engagement, use, or adherence (n=13, 54.2%).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Explicit language eligibility or context was reported in 16 of 24 reports (66.7%).
“explicit language eligibility or context in 16 (66.7%);”
Quote in the paperNot a substantial claim - Findingown data§ Results
Psychological or psychosocial clinical outcomes were reported or planned in 8 of 24 reports (33.3%).
“Psychological or psychosocial clinical outcomes were reported or planned in 8 (33.3%) reports.”
Quote in the paperNot a substantial claim - Findingown data§ Results
Acceptability, satisfaction, or user experience was the most frequently reported evaluation domain, in 17 of 24 reports (70.8%).
“Across the 24 reports, acceptability, satisfaction, or user experience was the most frequently reported evaluation domain (n=17, 70.8%),”
Quote in the paperNot a substantial claim - Findingown data§ Results
An explicit theoretical or conceptual framework was reported in 6 of 24 reports (25%).
“Explicit theoretical or conceptual framework 6 (25)”
- Also stated in: § Results · plain
“An explicit theoretical or conceptual framework was reported in 25% (6/24) of reports;”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
Rule-, knowledge-, or retrieval-based text agent was the primary AI system form in 6 of 23 projects (26.1%).
“Rule-, knowledge-, or retrieval-based text agent 6 (26.1)”
Quote in the paperNot a substantial claim - Findingown data§ Results
Human or expert oversight was reported in 15 of 24 reports (62.5%).
“human or expert oversight in 15 (62.5%),”
Quote in the paperNot a substantial claim - Findingown data§ Results
Safety or adverse event evaluation was reported in 4 of 24 reports (16.7%).
“and safety or adverse event evaluation in 4 (16.7%).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Privacy or data protection was reported in 13 of 24 reports (54.2%).
“privacy or data protection in 13 (54.2%),”
Quote in the paperNot a substantial claim - Findingown data§ Results
Symptom, sleep, or quality-of-life outcomes were reported in 6 of 24 reports (25%).
“and symptom, sleep, or quality-of-life outcomes in 6 (25%).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Structured psychological or behavioral intervention was mapped as a psychological support function in 7 of 23 projects (30.4%).
“Structured psychological or behavioral intervention 7 (30.4)”
- Also stated in: § Results · plain
“structured psychological or behavioral intervention in 7 (30.4%),”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
Crisis escalation, referral, or high-risk response was described in 8 of 24 reports (33.3%).
“Crisis escalation, referral, or high-risk response was described in 33.3% (8/24) of reports,”
Quote in the paperNot a substantial claim - Findingown data§ Results
Symptom or self-management support was mapped as a psychological support function in 20 of 23 projects (87%).
“Symptom or self-management support 20 (87)”
- Also stated in: § Results · plain
“symptom or self-management support in 20 (87%),”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
Disclosure or communication facilitation was mapped as a psychological support function in 6 of 23 projects (26.1%).
“Disclosure or communication facilitation 6 (26.1)”
- Also stated in: § Results · plain
“disclosure or communication facilitation in 6 (26.1%).”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
Social robot or embodied agent was the primary AI system form in 1 of 23 projects (4.3%).
“Social robot or embodied agent 1 (4.3)”
Quote in the paperNot a substantial claim - Findingown data§ Results
Feasibility was reported in 6 of 24 reports (25%).
“Feasibility was reported in 6 (25%) reports and usability in 8 (33.3%).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Voice assistant or smart speaker was the primary AI system form in 3 of 23 projects (13%).
“Voice assistant or smart speaker 3 (13)”
Quote in the paperNot a substantial claim - Findingown data§ Results
Education, occupation, or income-related variables were reported in 14 of 24 reports (58.3%).
“education, occupation, or income-related variables in 14 (58.3%);”
Quote in the paperNot a substantial claim - Findingown data§ Results
Usability was reported in 8 of 24 reports (33.3%).
“Feasibility was reported in 6 (25%) reports and usability in 8 (33.3%).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Advanced or metastatic disease was represented in 4 of 24 reports (16.7%).
“and advanced or metastatic disease in 4 (16.7%).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Emotional support was mapped as a psychological support function in 12 of 23 projects (52.2%).
“Emotional support 12 (52.2)”
- Also stated in: § Results · plain
“emotional support in 12 (52.2%),”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
Motivation or patient activation was mapped as a psychological support function in 10 of 23 projects (43.5%).
“Motivation or patient activation 10 (43.5)”
- Also stated in: § Results · plain
“motivation or patient activation in 10 (43.5%),”
Quote in the paperNot a substantial claim - Also stated in: § Results · plain
- Findingown data§ Results
Population and equity-related characteristics were inconsistently reported across the 24 reports.
“Population and equity-related characteristics were inconsistently reported across the 24 reports.”
Quote in the paperNot a substantial claim - Findingown data§ Results
Pediatric or adolescent and young adult representation was explicit in 6 of 24 reports (25%).
“Pediatric or adolescent and young adult representation was explicit in 6 (25%) reports,”
Quote in the paperNot a substantial claim - Findingown data§ Results
Ethics-related procedures were reported in 22 of 24 reports (91.7%).
“Of the 24 included reports, ethics-related procedures were reported in 22 (91.7%),”
Quote in the paperNot a substantial claim - Findingown data§ Results
Nonreplacement statements were described in 5 of 24 reports (20.8%).
“and nonreplacement statements in 20.8% (n=5).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Behavioral or self-management outcomes were reported in 9 of 24 reports (37.5%).
“behavioral or self-management outcomes in 9 (37.5%),”
Quote in the paperNot a substantial claim - Findingown data§ Results
Large language model or generative AI was the primary AI system form in 9 of 23 projects (39.1%).
“Large language model or generative AI 9 (39.1)”
Quote in the paperNot a substantial claim - Findingown data§ Results
Knowledge, attitudes, empowerment, patient activation, or self-efficacy outcomes were reported in 8 of 24 reports (33.3%).
“Knowledge, attitudes, empowerment, patient activation, or self-efficacy outcomes were reported in 8 (33.3%),”
Quote in the paperNot a substantial claim - Findingown data§ Results
No report established participant-level rurality (n=0).
“No report established participant-level rurality (n=0).”
Quote in the paperNot a substantial claim - Findingown data§ Results
Digital access or literacy was reported in 11 of 24 reports (45.8%).
“and digital access or literacy in 11 (45.8%).”
Quote in the paperNot a substantial claim - Findingown data§ Results
User-facing AI identity disclosure was described in 3 of 24 reports (12.5%).
“user-facing AI identity disclosure in 12.5% (n=3),”
Quote in the paperNot a substantial claim - Findingown data§ Results
No explicit theoretical basis was reported in 12 of 24 reports (50%).
“No explicit theoretical basis reported 12 (50)”
Quote in the paperNot a substantial claim - Findingown data§ Results
Race or ethnicity was reported in 4 of 24 reports (16.7%).
“Race or ethnicity was reported in 4 (16.7%) reports;”
Quote in the paperNot a substantial claim - Findingown data§ Results
Role boundaries were described in 6 of 24 reports (25%).
“role boundaries in 25% (n=6),”
Quote in the paperNot a substantial claim - Findingown data§ Results
Outcomes related to health care professionals or clinical workflows were reported in 5 of 24 reports (20.8%).
“Outcomes related to health care professionals or clinical workflows were reported in 5 (20.8%) reports,”
Quote in the paperNot a substantial claim - Findingown data§ Results
Accuracy or hallucination management was reported in 12 of 24 reports (50%).
“and accuracy or hallucination management in 12 (50%).”
Quote in the paperNot a substantial claim - Findingnone given§ Discussion
The included reports do not establish the effectiveness of nurse-AI collaboration.
“without establishing the effectiveness of nurse-AI collaboration”
Quote in the paperSubstantial claim - Findingnone given§ Discussion
Human oversight encompassed development, content validation, response review, monitoring, supervision, and referral.
“Human oversight encompassed development, content validation, response review, monitoring, supervision, and referral.”
Quote in the paperSubstantial claim - Findingcitation§ Discussion
Included reports illustrate nursing contributions to development, co-design, validation, or monitoring.
“Included reports illustrate nursing contributions to development, co-design, validation, or monitoring”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites Liu Z, Orouji F, Yang F, Shi Z, Liang H, Yu B, et al.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Tawfik E, Ghallab E, Moustafa A.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Hou M, Porter-Steele J, Balaam S, Chiu V, McCarthy S, Dobbins C, et al.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Findingnone given§ Discussion
15 of 24 reports described some oversight.
“Thus, 15 of 24 reports describing some oversight does not imply 15 clinically monitored systems.”
Quote in the paperNot a substantial claim - Findingreasoning§ Discussion
Safety and governance reporting showed a notable imbalance: conventional ethics-related procedures and some form of human or expert involvement were reported more often than operational safeguards such as crisis escalation, AI identity disclosure, explicit role boundaries, and nonreplacement statements.
“Safety and governance reporting showed a notable imbalance: conventional ethics-related procedures and some form of human or expert involvement were reported more often than operational safeguards such as crisis escalation, AI identity disclosure, explicit role boundaries, and nonreplacement statements.”
Quote in the paperSubstantial claim - Interpretationown data§ Abstract
Conversational AI research in psycho-oncology spans heterogeneous technologies and stages of development.
“Conversational AI research in psycho-oncology spans heterogeneous technologies and stages of development.”
Quote in the paperSubstantial claim - Interpretationown data§ Discussion
The smaller delivered-only counts show why proposed and simulated capabilities should be distinguished from implemented functions.
“The smaller delivered-only counts also show why proposed and simulated capabilities should be distinguished from implemented functions.”
Quote in the paperNot a substantial claim - Interpretationreasoning§ Discussion
Information and self-management functions may be easier to anchor to curated content or predefined workflows than sustained psychological interventions, which require therapeutic continuity and responses to deterioration or high-risk disclosures.
“Information and self-management functions may be easier to anchor to curated content or predefined workflows than sustained psychological interventions, which require therapeutic continuity and responses to deterioration or high-risk disclosures.”
Quote in the paperSubstantial claim - Interpretationreasoning§ Discussion
These findings support a distinction between demonstrating that a system can be used or is acceptable and demonstrating durable psychosocial benefit, safety, and clinical utility.
“These findings support a distinction between demonstrating that a system can be used or is acceptable and demonstrating durable psychosocial benefit, safety, and clinical utility.”
Quote in the paperSubstantial claim - Interpretationreasoning§ Discussion
The central concern is not the demonstrated exclusion of these groups but the limited ability to judge who can access, use, and benefit from the systems studied.
“The central concern is therefore not the demonstrated exclusion of these groups but the limited ability to judge who can access, use, and benefit from the systems studied.”
Quote in the paperSubstantial claim - Premisecitation§ Discussion
The cancer care-wide review by Jiang et al and the broader health care chatbot literature describe substantial heterogeneity in delivery modes, interaction logic, and implementation characteristics.
“This is consistent with the cancer care–wide review by Jiang et al [Jiang XH, Yuan XH, Zhao H, Peng JS. The effectiveness and feasibility of conversational agents in supporting care for patients with cancer: systematic review and meta-analysis. J Med Internet Res. Aug 08, 2025;27:e76968. [FREE Full text] [CrossRef] [Medline]9] and the broader health care chatbot literature [Laymouna M, Ma Y, Less”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Jiang et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Laymouna et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Interpretationreasoning§ Discussion
The pattern of evaluation outcomes is consistent with the developmental stage of the field.
“The pattern is also consistent with the developmental stage of the field.”
Quote in the paperNot a substantial claim - Interpretationown data§ Discussion
Population and equity-related reporting was insufficient to determine how representative the evidence base is.
“Population and equity-related reporting was insufficient to determine how representative the evidence base is.”
Quote in the paperSubstantial claim - Interpretationown data§ Discussion
The coexistence of LLM or generative AI systems with rule-, knowledge-, or retrieval-based agents, voice assistants, embodied systems, and multimodal platforms indicates that conversational AI in psycho-oncology should not be treated as a single intervention class.
“The coexistence of LLM or generative AI systems with rule-, knowledge-, or retrieval-based agents, voice assistants, embodied systems, and multimodal platforms indicates that conversational AI in psycho-oncology should not be treated as a single intervention class.”
Quote in the paperSubstantial claim - Premisecitation§ Discussion
A 2026 scoping review of safety mechanisms in generative AI mental health chatbots found that crisis referral protocols were often underdeveloped.
“This interpretation is consistent with a 2026 scoping review of safety mechanisms in generative AI mental health chatbots, which found that crisis referral protocols were often underdeveloped, systematic adverse event monitoring was sparse, and human oversight during intervention delivery was limited”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Olisaeloka L, Richardson CG, Wang AY, Munthali RJ, Vigo DV.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Premisecitation§ Discussion
General-purpose LLM evaluations have documented unsafe responses to patient-posed medical questions.
“General-purpose LLM evaluations have also documented unsafe responses to patient-posed medical questions”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Draelos RL, Afreen S, Blasko B, Brazile TL, Chase N, Desai DP, et al.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Study design and conductreasoning§ Discussion
The search may not capture later publications, commercial systems, or nonindexed work.
“The search ended on May 5, 2026, and may not capture later publications, commercial systems, or nonindexed work.”
Quote in the paperNot a substantial claim - Interpretationreasoning§ Discussion
The fact that 15 of 24 reports described some oversight does not imply that 15 systems were clinically monitored.
“Thus, 15 of 24 reports describing some oversight does not imply 15 clinically monitored systems.”
Quote in the paperSubstantial claim - Study design and conductreasoning§ Discussion
Without formal critical appraisal or meta-analysis, the review cannot establish effectiveness, safety, or certainty of evidence.
“Without formal critical appraisal or meta-analysis, the review cannot establish effectiveness, safety, or certainty of evidence.”
Quote in the paperSubstantial claim - Study design and conductnone given§ Discussion
Charting relied on explicit reporting and may underestimate undocumented theoretical, technical, population, or governance features.
“Charting relied on explicit reporting and may underestimate undocumented theoretical, technical, population, or governance features.”
Quote in the paperNot a substantial claim - Premisecitation§ Discussion
The same 2026 scoping review found that systematic adverse event monitoring was sparse.
“This interpretation is consistent with a 2026 scoping review of safety mechanisms in generative AI mental health chatbots, which found that crisis referral protocols were often underdeveloped, systematic adverse event monitoring was sparse, and human oversight during intervention delivery was limited”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Olisaeloka L, Richardson CG, Wang AY, Munthali RJ, Vigo DV.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Interpretationreasoning§ Discussion
Information, education, navigation, and selected self-management functions may complement existing care by extending access to standardized support and reinforcing patient preparation between clinical encounters.
“Information, education, navigation, and selected self-management functions may complement existing care by extending access to standardized support and reinforcing patient preparation between clinical encounters.”
Quote in the paperNot a substantial claim - Premisecitation§ Discussion
The same 2026 scoping review found that human oversight during intervention delivery was limited.
“This interpretation is consistent with a 2026 scoping review of safety mechanisms in generative AI mental health chatbots, which found that crisis referral protocols were often underdeveloped, systematic adverse event monitoring was sparse, and human oversight during intervention delivery was limited”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Olisaeloka L, Richardson CG, Wang AY, Munthali RJ, Vigo DV.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Interpretationreasoning§ Discussion
Taken together, the findings support a risk- and function-sensitive role for conversational AI within multidisciplinary psycho-oncology and supportive care pathways.
“Taken together, the findings support a risk- and function-sensitive role for conversational AI within multidisciplinary psycho-oncology and supportive care pathways.”
Quote in the paperNot a substantial claim - Interpretationreasoning§ Discussion
The current evidence supports evaluating conversational AI as an adjunct to, rather than a substitute for, professional psycho-oncology care.
“The current evidence therefore supports evaluating conversational AI as an adjunct to, rather than a substitute for, professional psycho-oncology care.”
Quote in the paperSubstantial claim
- May combine two claims. 40
- Classified as probably not a substantial claim. 56
- The quote only partly states this claim. 1
May combine two claims.
Premisecitation§ AbstractPsychological distress and unmet psychosocial needs are common across the cancer continuum.
“Psychological distress and unmet psychosocial needs are common across the cancer continuum.”
Quote in the paperSubstantial claim3 of 3 sources checked- cites [2] source
The Introduction says anxiety and depression are the most common psychological symptoms in patients with cancer, irrespective of disease stage or treatment phase. The Incidence and prevalence > Anxiety section identifies fear of recurrence as a common unmet need of cancer survivors, but does not establish that unmet psychosocial needs generally are common across the entire cancer continuum. Page numbers are not available in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measured - cites [3] source
- cites [4] source
The Conclusion reports that depression and anxiety are common among cancer survivors, and the Discussion describes psychological-support needs going unmet because of stigma and barriers to care. The paper does not establish that unmet psychosocial needs are common across the entire cancer continuum; its before-, during-, and after-treatment estimates concern pain, not those needs. (LLM, conf=0.84)
Experimental — accuracy not yet measured
May combine two claims.
Premisecitation§ IntroductionRelated reviews have examined health care chatbots and LLMs for cancer decision-making.
“Related reviews have examined health care chatbots [Laymouna M, Ma Y, Lessard D, Schuster T, Engler K, Lebouché B. Roles, users, benefits, and limitations of chatbots in health care: rapid review. J Med Internet Res. Jul 23, 2024;26:e56930. [FREE Full text] [CrossRef] [Medline]13] and LLMs for cancer decision-making”
Quote in the paperNot a substantial claim2 of 2 sources checkedProbably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ IntroductionCancer creates substantial needs for supportive care alongside diagnosis and treatment.
“Cancer creates substantial needs for supportive care alongside diagnosis and treatment.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [1] 2025, Lancet source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitation§ MethodsThe review was reported according to the PRISMA-ScR checklist.
“reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [20] source
Classified as probably not a substantial claim.
Premisecitation§ IntroductionUncertainty, fear of recurrence or progression, symptoms, functional disruption, and financial strain can contribute to distress, anxiety, depression, sleep disturbance, and unmet psychosocial needs.
“Uncertainty, fear of recurrence or progression, symptoms, functional disruption, and financial strain can contribute to distress, anxiety, depression, sleep disturbance, and unmet psychosocial needs”
Quote in the paperSubstantial claim2 of 2 sources checked- cites [2] source
The Incidence and prevalence > Anxiety section (page unavailable) says fear of recurrence or progression is a common unmet need and that intense fear can exacerbate anxiety, disturb sleep, and favour depression. The Risk factors sections also link physical symptoms and impaired functioning with anxiety, and lower socioeconomic status with depression. The Introduction describes uncertainty as a symptom rather than a contributor, and the passages found do not specifically establish financial strain as a cause of the listed outcomes. (LLM, conf=0.82)
Experimental — accuracy not yet measured - cites [3] source
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ IntroductionIndividual studies have investigated positive psychology support after cancer treatment.
“Individual studies have investigated positive psychology support after cancer treatment”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [10] source
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Premisecitation§ IntroductionAn umbrella review reported pooled prevalence estimates of 33.16% for depression and 30.55% for anxiety among patients with cancer.
“An umbrella review reported pooled prevalence estimates of 33.16% for depression and 30.55% for anxiety among patients with cancer”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [4] source
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ IntroductionTheir review also discussed therapeutic foundations and ethical concerns.
“Their review also discussed therapeutic foundations and ethical concerns.”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [18] source
Classified as probably not a substantial claim. May combine two claims.
Premisecitation§ IntroductionKılınç and Oflaz synthesized 7 English-language randomized trials of AI-based psychosocial interventions in cancer, including conversational and nonconversational tools, and assessed outcomes and risk of bias.
“synthesized 7 English-language randomized trials of AI-based psychosocial interventions in cancer, including conversational and nonconversational tools, and assessed outcomes and risk of bias.”
Quote in the paperSubstantial claim1 of 1 sources checked- cites [18] source
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ IntroductionEmpirical evaluations have considered response quality, empathy, and unsafe answers.
“while empirical evaluations have considered response quality, empathy, and unsafe answers”
Quote in the paperNot a substantial claim3 of 3 sources checked- cites [15] source
The Methods and Results report physician ratings of response quality and empathy, including medical accuracy. They do not report an evaluation of unsafe answers as a separate outcome; the paper’s recommendation for clinician oversight does not establish that such answers were measured. Page numbers were not provided in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured - cites [16] source
The Methods > Survey passage describes an empirical evaluation of perceived empathy in chatbot and physician responses. The Abstract reports a separate evaluation of response quality, but this study did not evaluate unsafe answers; it discusses misinformation as a concern for future assessments. No page numbers are available in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measured - cites [17] source
The Introduction and Methods describe an empirical evaluation of chatbot response quality and safety, including physician quality ratings and tags for unsafe responses. Our copy does not show an evaluation of empathy, so the cited paper supports only part of the claim. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Premisecitation§ IntroductionA systematic review and meta-analysis of 17 studies involving 1817 participants examined conversational agents across cancer care and identified heterogeneity in interventions, outcomes, and implementation.
“A systematic review and meta-analysis of 17 studies involving 1817 participants examined conversational agents across cancer care and identified heterogeneity in interventions, outcomes, and implementation”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [9] source
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ ResultsOf 2144 records screened, 2067 (96.4%) were excluded.
“After removing 1806 duplicate records (45.7% of those identified), 2144 records remained for title and abstract screening, of which 2067 (96.4%) were excluded.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ ResultsA total of 3950 records were identified through database and register searches.
“A total of 3950 records were identified through database and register searches.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown data§ ResultsThe remaining 77 reports were sought for retrieval, and 1 report could not be retrieved.
“The remaining 77 reports were sought for retrieval, and 1 report could not be retrieved.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown data§ AbstractThe review included 24 reports representing 25 study units and 23 underlying projects.
“We included 24 reports representing 25 study units and 23 underlying projects.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ ResultsAfter removing 1806 duplicate records, 2144 records remained for title and abstract screening.
“After removing 1806 duplicate records (45.7% of those identified), 2144 records remained for title and abstract screening, of which 2067 (96.4%) were excluded.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ ResultsAmong 76 full-text reports, 52 (68.4%) were excluded.
“Among these, 52 reports (68.4%) were excluded for the following reasons:”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingreasoning§ Results76 full-text reports were assessed for eligibility.
“Consequently, 76 full-text reports were assessed for eligibility.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown data§ ResultsReasons for exclusion were not involving the target population (n=6), not involving an AI conversational tool (n=9), not reporting psychological support functions or outcomes (n=8), ineligible evidence type (n=23), insufficient information (n=4), and duplicate publication (n=2).
“not involving the target population (n=6), not involving an AI conversational tool (n=9), not reporting psychological support functions or outcomes (n=8), ineligible evidence type (n=23), insufficient information (n=4), and duplicate publication (n=2).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown data§ DiscussionAcceptability, user experience, and engagement were reported more often than psychosocial clinical or safety outcomes, consistent with broader oncology and mental health chatbot evidence.
“Acceptability, user experience, and engagement were reported more often than psychosocial clinical or safety outcomes, consistent with broader oncology and mental health chatbot evidence”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Jiang et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Hua et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Findingown data§ ResultsDesigns included 6 randomized or crossover trial reports, 2 trial-derived secondary analyses, 6 nonrandomized user evaluations, and qualitative, co-design, simulated, development, or protocol reports.
“Designs included 6 randomized or crossover trial reports, 2 trial-derived secondary analyses, 6 nonrandomized user evaluations, and qualitative, co-design, simulated, development, or protocol reports.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingreasoning§ DiscussionThese non-mutually exclusive evaluation domains often co-occurred; the comparison concerns reporting frequency rather than separate types of study.
“These non–mutually exclusive domains often co-occurred; the comparison concerns reporting frequency rather than separate types of study.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ ResultsConcept or perception with no fixed deployed system was the primary AI system form in 3 of 23 projects (13%).
“Concept or perception; no fixed deployed system 3 (13)”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ ResultsOf the 24 included reports, 16 (66.7%) were published in 2025 or 2026.
“Of the 24 included reports, 16 (66.7%) were published in 2025 or 2026, and 6 (25%) were from the United States.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ ResultsMultimodal monitoring platform and chatbot was the primary AI system form in 1 of 23 projects (4.3%).
“Multimodal monitoring platform and chatbot 1 (4.3)”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone given§ ResultsThe 2 CanRelax reports represented a single study unit and project.
“The 2 CanRelax reports represented a single study unit and project;”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ Results6 (25%) of the 24 included reports were from the United States.
“Of the 24 included reports, 16 (66.7%) were published in 2025 or 2026, and 6 (25%) were from the United States.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingnone given§ ConclusionsConversational AI in cancer psychological support encompasses diverse technologies and functions, with more evidence on information provision and self-management than on delivered structured psychological interventions.
“Conversational AI in cancer psychological support encompasses diverse technologies and functions, with more evidence on information provision and self-management than on delivered structured psychological interventions.”
Quote in the paperSubstantial claimMay combine two claims.
Findingreasoning§ DiscussionIncluded designs ranged from protocols and simulated evaluations to trials, so mapped projects do not represent equivalent levels of clinical evidence.
“Included designs ranged from protocols and simulated evaluations to trials, so mapped projects do not represent equivalent levels of clinical evidence.”
Quote in the paperSubstantial claimMay combine two claims.
Findingreasoning§ ConclusionsThe present evidence map does not establish clinical effectiveness or readiness for routine use.
“The present evidence map does not establish clinical effectiveness or readiness for routine use.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown data§ AbstractClinical and safety evaluation, theoretical foundations, population representation, and oversight responsibilities remain incompletely reported.
“Clinical and safety evaluation, theoretical foundations, population representation, and oversight responsibilities remain incompletely reported.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone given§ MethodsDiscrepancies in charting were resolved through discussion, and a third reviewer was consulted when consensus could not be reached.
“Discrepancies were resolved through discussion, and a third reviewer was consulted when consensus could not be reached.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductnone given§ MethodsCoding was based on explicit full-text statements; titles, abstracts, author affiliations, and general background statements were not used to infer unreported features.
“Coding was based on explicit full-text statements; titles, abstracts, author affiliations, and general background statements were not used to infer unreported features.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsHuman oversight was charted only when explicitly described.
“Human oversight was charted only when explicitly described”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ AbstractNo formal critical appraisal was undertaken.
“No formal critical appraisal was undertaken.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone given§ MethodsUncertain codes were reassessed against the operational definitions, with disagreements and supporting source locations documented.
“Uncertain codes were reassessed against the operational definitions, with disagreements and supporting source locations documented.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone given§ MethodsDisagreements at either screening stage were resolved through discussion, and unresolved disagreements were adjudicated by a third reviewer.
“Disagreements at either screening stage were resolved through discussion, and unresolved disagreements were adjudicated by a third reviewer.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsTwo reviewers independently charted data from each included source using the finalized form.
“Two reviewers independently charted data from each included source using the finalized form.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Interpretationreasoning§ AbstractThese findings represent a map of reporting patterns and do not establish effectiveness or safety.
“These findings represent a map of reporting patterns and do not establish effectiveness or safety.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationreasoning§ MethodsInstitutional ethics review and informed consent were not required for this review.
“Institutional ethics review and informed consent were therefore not required.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductreasoning§ MethodsFormal critical appraisal and meta-analysis were not undertaken because the review aimed to map the evidence rather than estimate effectiveness.
“Formal critical appraisal and meta-analysis were not undertaken because the review aimed to map the evidence rather than estimate effectiveness.”
- Also stated in: § Results · plain
“No formal critical appraisal was undertaken.”
Quote in the paperSubstantial claim- Also stated in: § Results · plain
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsEach charted item retained a source locator (page, section, table, or quoted text, where available) to support auditability.
“Each charted item retained a source locator (page, section, table, or quoted text, where available) to support auditability.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsNo population was classified as underserved or vulnerable solely by reviewer inference.
“No population was classified as underserved or vulnerable solely by reviewer inference.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsNeither the "not reported" nor the "unclear" code was interpreted as evidence that a system feature or population characteristic was absent.
“Neither code was interpreted as evidence that a system feature or population characteristic was absent.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown data§ MethodsTwo reviewers independently screened titles and abstracts in Zotero using predefined tags and collections.
“Two reviewers then independently screened titles and abstracts in Zotero using predefined tags and collections.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown data§ MethodsFull texts were assessed independently by 2 reviewers against the eligibility criteria.
“Full texts were assessed independently by 2 reviewers against the eligibility criteria.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsThe protocol was prospectively registered on the OSF before formal title and abstract screening and data charting (UM65W).
“The protocol was prospectively registered on the OSF before formal title and abstract screening and data charting (UM65W).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown data§ MethodsThe data charting form was pilot-tested on 5-10 included reports representing different evidence types before full data charting.
“Before full data charting, the form was pilot-tested on 5-10 included reports representing different evidence types, including intervention, development or evaluation, usability, LLM response evaluation, qualitative or co-design, and protocol reports.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsBefore formal screening, 2 reviewers independently pilot-screened approximately 30-50 titles and abstracts to test the eligibility criteria and clarify operational definitions.
“Before formal screening, 2 reviewers independently pilot-screened approximately 30-50 titles and abstracts to test the eligibility criteria and clarify operational definitions.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsThe review questions and eligibility criteria were unchanged.
“The review questions and eligibility criteria were unchanged.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitation§ MethodsThe scoping review was conducted in accordance with Joanna Briggs Institute (JBI) methodology.
“This scoping review was conducted in accordance with Joanna Briggs Institute (JBI) methodology”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [19] Peters, MD, 2024, JBI Manual for Evidence Synthesis source
May combine two claims.
Study design and conductreasoning§ MethodsThis review analyzed published and publicly available literature and did not involve the collection of identifiable human participant data.
“This review analyzed published and publicly available literature and did not involve the collection of identifiable human participant data.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ IntroductionIndividual studies have investigated ChatGPT-based counseling before chemotherapy.
“ChatGPT-based counseling before chemotherapy”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [12] source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsAny amendments to the registered protocol were documented on OSF, including the date, description, and rationale for each change.
“Any amendments to the registered protocol were documented on OSF, including the date, description, and rationale for each change.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone given§ MethodsInformation not explicitly described in the report was coded as "not reported"; information present but not reliably classifiable was coded as "unclear."
“Information not explicitly described in the report was coded as “not reported”; information that was present but could not be classified reliably was coded as “unclear.””
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ MethodsFollowing peer review, the review team refined the charting of support functions, theoretical foundations, system types, human oversight, and population characteristics across the 24 included reports.
“Following peer review, the review team refined the charting of support functions, theoretical foundations, system types, human oversight, and population characteristics across the 24 included reports.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown data§ DiscussionTheoretical foundations, population characteristics, and operational oversight were incompletely reported.
“Theoretical foundations, population characteristics, and operational oversight were incompletely reported.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown data§ DiscussionOnly one-quarter of reports named a theoretical or conceptual framework, which provides a complementary perspective to outcome-focused reviews, but neither a therapeutic component nor a named framework demonstrates that a psychosocial mechanism was tested.
“Only one-quarter of reports named a theoretical or conceptual framework. This provides a complementary perspective to outcome-focused reviews”
- Also stated in: § Discussion · plain
“but neither a therapeutic component nor a named framework demonstrates that a psychosocial mechanism was tested.”
Quote in the paperSubstantial claim0 of 3 sources checked- cites Nezenega et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Kılınç and Oflaz
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Zhang et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Also stated in: § Discussion · plain
May combine two claims.
Premisecitation§ DiscussionBroader mental health evidence suggests that efficacy is beginning to emerge but remains uncertain.
“Broader mental health evidence suggests that efficacy is beginning to emerge but remains uncertain.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationcitation§ DiscussionSystem architecture affects the balance between conversational flexibility and content control: more open-ended generation may support personalization and empathic interaction, whereas more constrained systems may permit tighter control over content and response pathways.
“These findings matter because system architecture affects the balance between conversational flexibility and content control: more open-ended generation may support personalization and empathic interaction, whereas more constrained systems may permit tighter control over content and response pathways.”
Quote in the paperSubstantial claimMay combine two claims.
Premisecitation§ DiscussionA subsequent 2026 systematic review of general-purpose LLMs in mental health care found that most evidence came from vignette, simulation, or retrospective studies, with sparse prospective real-world evaluation and generally low certainty across clinical domains.
“A subsequent 2026 systematic review of general-purpose LLMs in mental health care found that most evidence came from vignette, simulation, or retrospective studies, with sparse prospective real-world evaluation and generally low certainty across clinical domains”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Leung et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Interpretationown data§ DiscussionEvaluation emphasized acceptability and engagement, with psychosocial clinical and safety assessments reported less frequently.
“Evaluation emphasized acceptability and engagement, with psychosocial clinical and safety assessments reported less frequently.”
Quote in the paperSubstantial claimThe quote only partly states this claim.
Interpretationreasoning§ DiscussionThe wider representation of information and self-management functions may be explained by their greater ease of anchoring to curated content or predefined workflows, consistent with broader oncology evidence.
“This may help explain their wider representation, consistent with broader oncology evidence”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Jiang et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Interpretationown data§ DiscussionOlder adults, people with advanced or metastatic disease, and several characteristics relevant to equity, including race or ethnicity, rurality, language, and digital access or literacy, were incompletely reported.
“Older adults, people with advanced or metastatic disease, and several characteristics relevant to equity, including race or ethnicity, rurality, language, and digital access or literacy, were incompletely reported.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Premisecitation§ DiscussionA recent systematic review of 160 mental health chatbot studies documented a rapid transition from rule-based systems toward LLM-based approaches, while noting that most LLM studies remained at early validation stages.
“A recent systematic review of 160 mental health chatbot studies likewise documented a rapid transition from rule-based systems toward LLM-based approaches, while noting that most LLM studies remained at early validation stages”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Hua et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ DiscussionBroader generative AI mental health evidence has similarly identified limited study of older adults.
“Broader generative AI mental health evidence has similarly identified limited study of older adults”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Zhang et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Interpretationown data§ DiscussionInformation or education and symptom or self-management functions predominated, whereas delivered structured psychological interventions were less common.
“Information or education and symptom or self-management functions predominated, whereas delivered structured psychological interventions were less common.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
Interpretationnone given§ DiscussionThe varied disciplinary origins and developmental purposes of these systems may contribute to inconsistent theory reporting.
“The varied disciplinary origins and developmental purposes of these systems may contribute to inconsistent theory reporting.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationreasoning§ DiscussionMany included reports were feasibility or pilot studies, co-design studies, simulated response evaluations, system development studies, or protocols, for which usability, acceptability, and engagement are appropriate early-stage outcomes.
“Many included reports were feasibility or pilot studies, co-design studies, simulated response evaluations, system development studies, or protocols, for which usability, acceptability, and engagement are appropriate early-stage outcomes.”
Quote in the paperSubstantial claimMay combine two claims.
Premisecitation§ DiscussionA 2025 systematic review and meta-analysis of generative AI mental health chatbots found a modest average reduction in negative mental health outcomes but with substantial heterogeneity and wide prediction intervals.
“A 2025 systematic review and meta-analysis of generative AI mental health chatbots found a modest average reduction in negative mental health outcomes but with substantial heterogeneity and wide prediction intervals”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Zhang et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Classified as probably not a substantial claim.
Interpretationnone given§ ResultsFrequencies describe reporting patterns and should not be interpreted as measures of study quality, effectiveness, safety, or clinical readiness.
“Frequencies describe reporting patterns and should not be interpreted as measures of study quality, effectiveness, safety, or clinical readiness.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationreasoning§ DiscussionGeneral-purpose LLMs were eligible only within studied oncology support contexts; findings therefore cannot characterize unstudied, independent everyday use by people with cancer.
“General-purpose LLMs were eligible only within studied oncology support contexts; findings therefore cannot characterize unstudied, independent everyday use by people with cancer.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable).
Interpretationreasoning§ DiscussionMore complex emotional support or structured psychological intervention requires stronger evidence of therapeutic benefit, continuity, and safety, particularly when systems may encounter severe distress or other high-risk disclosures.
“More complex emotional support or structured psychological intervention requires stronger evidence of therapeutic benefit, continuity, and safety, particularly when systems may encounter severe distress or other high-risk disclosures.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Premisecitation§ DiscussionEvidence on LLMs in mental health warrants caution about unsupervised high-risk use.
“Evidence on LLMs in mental health similarly warrants caution about unsupervised high-risk use”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Leung J, Johnson B, McRae K, Fong S, Gonzalez PC, McClure-Thomas C, et al.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Premisecitation§ DiscussionA subsequent scoping review of equity in digital oncology reported geographic and population gaps, persistent technical access barriers, and associations between socioeconomic factors and uptake.
“A subsequent scoping review of equity in digital oncology reported geographic and population gaps, persistent technical access barriers, and associations between socioeconomic factors and uptake”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Prakash et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Interpretationreasoning§ DiscussionOne possible explanation for the imbalance is that institutional research ethics and privacy procedures are already embedded in established research governance, whereas AI-specific safeguards for open-ended conversational systems are newer and less standardized.
“One possible explanation is that institutional research ethics and privacy procedures are already embedded in established research governance, whereas AI-specific safeguards for open-ended conversational systems are newer and less standardized.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
Interpretationnone given§ DiscussionFormative and simulated studies may prioritize interaction quality over representativeness.
“Formative and simulated studies may prioritize interaction quality over representativeness.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
Interpretationnone given§ DiscussionSeparating delivered functions from other evidence states improves the interpretability of the evidence map.
“Separating delivered functions from other evidence states improves the interpretability of the evidence map.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ DiscussionCancer distress guidance supports clear assessment and referral pathways.
“Cancer distress guidance supports clear assessment and referral pathways”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Weis J, Mehnert-Theuerkauf AK, Bruns G, Maatouk I, Jentschke E, Riedner C, et al.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Andersen BL, Lacchetti C, Ashing K, Berek JS, Berman BS, Bolte S, et al.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone given§ DiscussionThe review had a registered protocol, multidisciplinary search, independent screening and charting, and explicit linkage of reports, study units, and projects.
“Strengths include a registered protocol, multidisciplinary search, independent screening and charting, and explicit linkage of reports, study units, and projects.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisecitation§ DiscussionA 2026 qualitative systematic review found that older adults with cancer can value digital interventions for information access and self-management but also encounter technical difficulties, suboptimal content design, and heterogeneous support needs.
“In oncology specifically, a 2026 qualitative systematic review found that older adults with cancer can value digital interventions for information access and self-management but also encounter technical difficulties, suboptimal content design, and heterogeneous support needs”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Zhang J et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone given§ DiscussionIncomplete project identifiers may affect report linkage.
“Incomplete project identifiers may also affect report linkage.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisecitation§ DiscussionAge, functional burden, language, digital access, and support needs can affect use in oncology.
“Nevertheless, age, functional burden, language, digital access, and support needs can affect use in oncology”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Zhang J et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Prakash et al
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
The paper relies on this without support.
The technologies, support functions, evaluation approaches, and safety governance of conversational AI agents for psychological support of patients with cancer remain fragmented.
“Conversational AI agents may offer scalable support, but their technologies, support functions, evaluation approaches, and safety governance remain fragmented.”
The paper relies on this without support.
A focused synthesis is needed to characterize the psychological support functions and conditions of use of conversational AI agents in oncology.
“A focused synthesis is needed to characterize their psychological support functions and conditions of use.”
The paper relies on this without support.
Conversational AI agents may offer scalable support.
“Conversational AI agents may offer scalable support”
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Technology Based Supportive Care for Metastatic Breast Cancer Patients
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Flagged first, then by citations
Research works printed but not linked: 3
- Peters, MD, 2024, JBI Manual for Evidence Synthesis
- Seo, W, 2025, CHI '25: Proceedings of the 2025 CHI Conference on Human Factors in Computing Systems, 1
- 10.2440/006-0040 · DOI
- Authors
- Shen, Z., Shi, S., Mao, L., Li, C., & Xie, J.
- Affiliations
- Central South University (CN)
- Venue
- Journal of Medical Internet Research
- Publisher
- JMIR Publications Inc.
- Published
- 2026-10-19
- Volume
- 28
- Pages
- e105599
- ISSN
- 1438-8871 (ISSN-L)
- OpenAlex
- W7214155080
- Semantic Scholar
- 737f2260a646aff3cc9da31b2ed744fef4002d40
- Cited by
- 0
- References
- 45
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Medical Internet Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Social Psychology › Social Robot Interaction and HRI
- Keywords
- chatbots, psychological support, cancer patients, mental health support, safety governance, evaluation results
- MeSH terms
- Generative Artificial Intelligence, Artificial Intelligence, Communication, Humans, Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-23.
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