Implementing a machine learning screening tool for malnutrition: insights from qualitative research applicable to other machine learning-based clinical decision support systems
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Abstract
Background: Machine learning (ML)–based clinical decision support systems (CDSS) are popular in clinical practice settings but are often criticized for being limited in usability, interpretability, and effectiveness. Evaluating the implementation of ML-based CDSS is critical to ensure CDSS is acceptable and useful to clinicians and helps them deliver high-quality health care. Malnutrition is a common and underdiagnosed condition among hospital patients, which can have serious adverse impacts. Early identification and treatment of malnutrition are important. Objective: This study aims to evaluate the implementation of an ML tool, Malnutrition Universal Screening Tool (MUST)–Plus, that predicts hospital patients at high risk for malnutrition and identify best implementation practices applicable to this and other ML-based CDSS. Methods: We conducted a qualitative postimplementation evaluation using in-depth interviews with registered dietitians (RDs) who use MUST-Plus output in their everyday work. After coding the data, we mapped emergent themes onto select domains of the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) framework. Results: We interviewed 17 of the 24 RDs approached (71%), representing 37% of those who use MUST-Plus output. Several themes emerged: (1) enhancements to the tool were made to improve accuracy and usability; (2) MUST-Plus helped identify patients that would not otherwise be seen; perceived usefulness was highest in the original site; (3) perceived accuracy varied by respondent and site; (4) RDs valued autonomy in prioritizing patients; (5) depth of tool understanding varied by hospital and level; (6) MUST-Plus was integrated into workflows and electronic health records; and (7) RDs expressed a desire to eventually have 1 automated screener. Conclusions: Our findings suggest that continuous involvement of stakeholders at new sites given staff turnover is vital to ensure buy-in. Qualitative research can help identify the potential bias of ML tools and should be widely used to ensure health equity. Ongoing collaboration among CDSS developers, data scientists, and clinical providers may help refine CDSS for optimal use and improve the acceptability of CDSS in the clinical context.
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Integration with electronic health records was common, particularly in more mature tools.
“Integration with electronic health records (EHRs) was common, particularly in more mature tools [23,24,26–34,36].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
The Introduction says MUST-Plus was integrated into Epic and describes its refinement, rollout across hospitals, and subsequent versions. The Abstract’s Results also state that it was integrated into electronic health records. This supports MUST-Plus as an example, but the paper does not establish that EHR integration was common across tools or particularly prevalent in more mature ones. (LLM, conf=0.82)
Experimental — accuracy not yet measuredHealth professionals positively perceived, and were more likely to use, XAI systems that fit into their existing workflow.
“Health professionals positively perceived, and were more likely to use, XAI systems that fit into their existing workflow [23–26,30,31,33,35].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
The Discussion (Principal Results; page unavailable) says the ML screening tool was well received by dietitians and had positive effects on their workflow; the Results (Overview; page unavailable) says workflow changes were minimal and well received. The paper does not establish that the tool was an XAI system or that workflow fit made health professionals more likely to use it. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPerceptions of the XAI model's data quality impacted participants' trust and use of tools, and trust in outputs was reduced when XAI systems used hospital data that participants knew was unreliable.
“Similarly, perceptions of the XAI model’s data quality impacted participants trust and use of tools and trust in outputs were reduced when XAI system’s used hospital data that participants knew was unreliable [23,25,26,29,32,33,36].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
The Results (NASSS Framework Domain: Value Proposition; page not provided) report that dietitians identified data-entry errors and missing patient data as causes of inaccurate MUST-Plus scores. The same section says low perceived accuracy may reduce trust and lead to scores being ignored. The paper does not establish the broader claim about XAI systems using hospital data participants knew was unreliable; it describes dietitians’ perceptions of one malnutrition-screening tool. (LLM, conf=0.82)
Experimental — accuracy not yet measuredWhile several systems had been implemented or were near live, the majority remained at prototype or pre-implementation stages.
“While several systems had been implemented or were near live [26,30,31,33,36], the majority remained at prototype or pre-implementation stages.”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Participants commonly reported that XAI tools support task completion.
“Across these studies participants commonly reported that the XAI tools support task completion [23,26,28,29,31,33].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
The theme perceived usefulness was identified in 13 papers.
“The theme perceived usefulness was identified in 13 papers, where participants reported the how the systems impacted their work and associated tasks [23,24,26,28–33,35–38].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Eight studies linked perceived usefulness to the tool's impact on workload.
“Eight studies linked perceived usefulness to the tool’s impact on workload [26,29–31,33,35,37,38].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Impact on workflow arose as a theme in 9 papers.
“Impact in workflow related to how XAI systems aligned with and influenced work processes, and arose as a theme in 9 papers [23–27,30,31,33,35].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Education and training was a theme that arose in 9 studies.
“Education and training was a theme that arose in 9 studies, where participants described their need for, or experience of, learning how to use the XAI system [23,25,26,28–30,32,35,36].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Aligning the XAI tool with existing systems such as embedding it into the hospital electronic health record was important.
“Similarly aligning the XAI tool with existing systems such as embedding it into the hospital electronic health record was important [23,26,35].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
In three studies of XAI tools that were already implemented, some participants lacked understanding of the model or features.
“In three studies of XAI tools that were already implemented, some participants lacked understanding of the model or features [26,30,36].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
In Besculides et al.'s study the XAI tool was already implemented and was perceived to increase workload as it identified more high-risk patients needing review.
“Conversely, in Besculides et al.’s [26] study the XAI tool was already implemented and was perceived to increase workload as it identified more high-risk patients needing review.”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Perceptions on the model's performance were reported in 13 studies.
“Perceptions on the model’s performance was reported in 13 studies [23–26,29–37].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Besculides et al. found depth of understanding differed for those who were trained by the data science team and those who were trained by supervisors or managers.
“Besculides et al. [26] also found depth of understanding differed for those who were trained by data science team and those who were trained by supervisors or managers.”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Participants wanted to exercise their professional judgement and override the XAI recommendations when perceived to be inaccurate.
“Participants wanted to exercise their professional judgement and override the XAI recommendations when perceived to be inaccurate [26], and were concerned “that regulatory agencies might use these systems to standardize care even in scenarios where a clinician disagrees with the system, potentially leading to overtreatment and patient harm” [30].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Validation of the model output was a major reason for explainability, reported in nine studies.
“Validation of the model output was a major reason for explainability, and was reported in nine studies [25–27,30,32,33,35,36,38].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Besculides et al. reported dieticians checked factors contributing to the score when they questioned the prediction.
“Besculides et al. [26] reported dieticians checked factors contributing to the score when they questioned the prediction.”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Participants had concerns with performance regarding unique patients believed to be outliers.
“Participants also had concerns with performance regarding unique patients believed to be outliers [25,26,29,36].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Five studies included perceptions related to health professionals' autonomy.
“Five studies included perceptions related to health professionals’ autonomy [26,29,30,33,35].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
In Besculides et al.'s study of a system to predict patient risk of malnutrition, participants reported they did not mention the prediction score to patients and communication with patients remained the same post-implementation.
“In contrast, in Besculidies et al’s [26] study of a system to predict patient risk of malnutrition, participants reported that they did not mention the prediction score to patients and communication with patients remained the same post-implementation.”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
Health professionals' perceptions involving design and usability were found in 14 papers.
“Health professionals’ perceptions involving design and usability were found in 14 papers [23–34,37,38].”
From Explainable AI in hospital clinical decision support systems: A scoping review of healthcare professionals’ perspectives (2026) · cites this paper as [26]
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- Authors
- Besculides, M., Mazumdar, M., Phlegar, S., Freeman, R., Wilson, S., Joshi, H., Kia, A., & Gorbenko, K.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Tisch Cancer Institute (US)
- New York University (US)
- Corresponding author
- Besculides, Melanie
- ORCID
- Venue
- JMIR Formative Research
- Publisher
- JMIR Publications Inc.
- Published
- 2023-07-13
- Volume
- 7
- Pages
- e42262
- ISSN
- 2561-326X (ISSN-L)
- PMC
- PMC10375393
- OpenAlex
- W4318658936
- Cited by
- 12
- References
- 37
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JMIR Formative Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Keywords
- Malnutrition Universal Screening Tool, machine learning, clinical decision support systems, malnutrition screening, hospitalized patients, implementation evaluation, registered dietitians, NASSS framework, stakeholder engagement, perceived usefulness, electronic health records, automated screening, health equity, algorithmic bias
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