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PreprintCited by 2Chronic Disease Management StrategiesInterprofessional Education and CollaborationHealth Policy Implementation Science

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Effectiveness of Collaborative Care Interventions for the Management of Patients With Multimorbidity: Protocol for a Systematic Review, Meta-Analysis, and Meta-Regression Analysis (Preprint)

Open access
Knudsen, Anne-Maj, Dalgård Dunvald, Ann-Cathrine, Hangaard, Stine, Hejlesen, Ole, Kronborg, Thomas·2024·JMIR Research Protocols
DOI 10.2196/preprints.58296PMC PMC11342003

Preprint — published as 10.2196/58296

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Abstract

BACKGROUND: Collaborative care interventions have been proposed as a promising strategy to support patients with multimorbidity. Despite this, the effectiveness of collaborative care interventions requires further evaluation. Existing systematic reviews describing the effectiveness of collaborative care interventions in multimorbidity management tend to focus on specific interventions, patient subgroups, and settings. This necessitates a comprehensive review that will provide an overview of the effectiveness of collaborative care interventions for adult patients with multimorbidity. OBJECTIVE: This systematic review aims to systematically assess the effectiveness of collaborative care interventions in comparison to usual care concerning health-related quality of life (HRQoL), mental health, and mortality among adult patients with multimorbidity. METHODS: Randomized controlled trials evaluating collaborative care interventions designed for adult patients (18 years and older) with multimorbidity compared with usual care will be considered for inclusion in this review. HRQoL will be the primary outcome. Mortality and mental health outcomes such as rating scales for anxiety and depression will serve as secondary outcomes. The systematic search will be conducted in the CENTRAL, PubMed, CINAHL, and Embase databases. Additional reference and citation searches will be performed in Google Scholar, Web of Science, and Scopus. Data extraction will be comprehensive and include information about participant characteristics, study design, intervention details, and main outcomes. Included studies will be assessed for limitations according to the Cochrane Risk of Bias tool. Meta-analysis will be conducted to estimate the pooled effect size. Meta-regression or subgroup analysis will be undertaken to explore if certain factors can explain the variation in effect between studies, if feasible. The certainty of evidence will be evaluated using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. RESULTS: The preliminary literature search was performed on February 16, 2024, and yielded 5255 unique records. A follow-up search will be performed across all databases before submission. The findings will be presented in forest plots, a summary of findings table, and in narrative format. This systematic review is expected to be completed by late 2024. CONCLUSIONS: This review will provide an overview of pooled estimates of treatment effects across HRQoL, mental health, and mortality from randomized controlled trials evaluating collaborative care interventions for adults with multimorbidity. Furthermore, the intention is to clarify the participant, intervention, or study characteristics that may influence the effect of the interventions. This review is expected to provide valuable insights for researchers, clinicians, and other decision-makers about the effectiveness of collaborative care interventions targeting adult patients with multimorbidity. CLINICALTRIAL: International Prospective Register of Systematic Reviews (PROSPERO) CRD42024512554; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=512554 INTERNATIONAL REGISTERED REPORT: DERR1-10.2196/58296

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Metadata

Authors
Knudsen, A.-M., Dalgård Dunvald, A.-C., Hangaard, S., Hejlesen, O., & Kronborg, T.
Affiliations
  • Aalborg University Hospital (DK)
  • Aalborg University (DK)
Corresponding author
Knudsen, Anne-Maj
ORCID
Venue
JMIR Research Protocols
Publisher
JMIR Publications Inc.
Published
2024-03-12
Volume
13
Pages
e58296-e58296
ISSN
1929-0748 (ISSN-L)
DOI
10.2196/preprints.58296
PMC
PMC11342003
OpenAlex
W4400473055
Cited by
2
References
1
Citations by year
2026: 1 · 2025: 1
FWCI
0.13
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • JMIR Research Protocols (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Funders
  • Aalborg Universitet
  • Novo Nordisk
  • Novo Nordisk Fonden (NNF17SA0031404-1)
Topics
  • Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
  • Health Sciences › Health Professions › General Health Professions › Interprofessional Education and Collaboration
  • Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
Keywords
collaborative care, multimorbidity, health-related quality of life, mental health, anxiety, depression, mortality, usual care comparison, adults, treatment effectiveness, effect modifiers, meta-regression, subgroup analysis, risk of bias, GRADE certainty of evidence, chronic disease management, patient-centered care, shared decision-making, patient engagement, patient education, patient support groups
MeSH terms
Multimorbidity, Systematic Reviews as Topic, Cooperative Behavior, Humans, Patient Care Management, Quality of Life, Regression Analysis, Meta-Analysis as Topic, Randomized Controlled Trials as Topic

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