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Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study (Preprint)
Open accessPreprint — published as 10.2196/63176 · Paper page
Abstract
BACKGROUND: Micro- and nanoplastics (MNPs) are emerging pollutants of concern with ubiquitous presence in global ecosystems. MNPs pose potential implications for human health; however, the health impacts of MNP exposures are not yet understood. Recent evidence suggests that MNPs can cross the placental barrier, underlying the urgent need to understand their impact on reproductive health and development. OBJECTIVE: The Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics (AURORA) project will investigate MNP exposures and their biological and health effects during pregnancy and early life, which are critical periods due to heightened vulnerability to environmental stressors. The AURORA project will enhance exposure assessment capabilities for measuring MNPs, MNP-associated chemicals, and plastic additives in human tissues, including placenta and blood. METHODS: In this interdisciplinary project, we will advance methods for in-depth characterization and scalable chemical analytical strategies, enabling high-resolution and large-scale toxicological, exposure assessment, and epidemiological studies. The AURORA project performs observational studies to investigate determinants and health impacts of MNPs by including 800 mother-child pairs from 2 existing birth cohorts and 110 women of reproductive age from a newly established cohort. This will be complemented by toxicological studies using a tiered-testing approach and epidemiological investigations to evaluate associations between maternal and prenatal MNP exposures and health perturbations, such as placental function, immune-inflammatory responses, oxidative stress, accelerated aging, endocrine disruption, and child growth and development. The ultimate goal of the AURORA project is to create an MNP risk assessment framework and identify the remaining knowledge gaps and priorities needed to comprehensively assess the impact of MNPs on early-life health. RESULTS: In the first 3 years of this 5-year project (2021-2026), progress was made toward all objectives. This includes completion of recruitment and data collection for new and existing cohorts, development of analytical methodological protocols, and initiation of the toxicological tiered assessments. As of September 2024, data analysis is ongoing and results are expected to be published starting in 2025. CONCLUSIONS: As plastic pollution increases globally, it is imperative to understand the impact of MNPs on human health, particularly during vulnerable developmental stages such as early life. The contributions of the AURORA project will inform future risk assessment. INTERNATIONAL REGISTERED REPORT: DERR1-10.2196/63176
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Andonotopo, W., Bachnas, M. A., Dewantiningrum, J., Pramono, M. B. A., Sanjaya, I. N. H., Stanojević, M., & Kurjak, A. (2025) · Sarvodaya International Journal of Medicine · doi:10.4103/sijm.sijm_24_25 · Cited by 23
Prenatal microplastic exposure and umbilical cord blood androgenic and glucocorticoid hormones.
Liu, B.-Y., Zheng, D.-M., Wang, J., Wang, D., Zhang, S., & Chu, D. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118827 · Cited by 17
Moulton, C., Baroni, A., & Tasciotti, E. (2026) · Journal of Xenobiotics · doi:10.3390/jox16020052 · Cited by 18
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A Critical Evaluation of Nano‐ and Microplastics: Sources, Health Risks, and Mitigation Strategies
Njema, G. G., Agoro, M. A., & Kibet, J. K. (2026) · Advances in Materials Science and Engineering · doi:10.1155/amse/1357400 · Cited by 7
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Nanoplastics at the Placenta–Fetal Interface: Emerging Chemical Toxicology Concerns
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Khasanov, R., Boettcher, M., Wessel, L. M., Schãfer, K.-H., & Tapia-Laliena, M. Á. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1756622
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Metadata
- Authors
- Durkin, A. M., Zou, R., Boucher, J. M., Boyles, M. S., van Boxel, J., Bustamante, M., Christopher, E. A., Dadvand, P., Dusza, H. M., van Duursen, M., Forsberg, M. M., Galea, K. S., Legler, J., Mandemaker, L. D., Meirer, F., Muncke, J., Nawrot, T. S., Přibylová, P., Robuck, A. R., Saenen, N. D., Scholz-Böttcher, B. M., Shao, K., Vrijheid, M., Walker, D. I., Zimmermann, L., Zoutendijk, L. M., Lenters, V., & Vermeulen, R.
- Affiliations
- Utrecht University (NL)
- Food Packaging Forum Foundation (CH)
- Vrije Universiteit Amsterdam (NL)
- Universitat Pompeu Fabra (ES)
- Institute of Occupational Medicine (GB)
- University of Eastern Finland (FI)
- Hasselt University (BE)
- Icahn School of Medicine at Mount Sinai (US)
- Emory University (US)
- University Medical Center Utrecht (NL)
- Corresponding author
- Vermeulen, Roel
- ORCID
- Durkin, Amanda M
- Zou, Runyu
- Boucher, Justin M
- Boyles, Matthew SP
- van Boxel, Jeske
- Bustamante, Mariona
- Christopher, Emily A
- Dadvand, Payam
- Dusza, Hanna M
- van Duursen, Majorie
- Forsberg, Markus M
- Galea, Karen S
- Legler, Juliette
- Mandemaker, Laurens DB
- Meirer, Florian
- Muncke, Jane
- Nawrot, Tim S
- Přibylová, Petra
- Robuck, Anna R
- Saenen, Nelly D
- Scholz-Böttcher, Barbara M
- Shao, Kuanliang
- Vrijheid, Martine
- Walker, Douglas I
- Zimmermann, Lisa
- Zoutendijk, Laura M
- Lenters, Virissa
- Vermeulen, Roel
- Venue
- JMIR Research Protocols
- Publisher
- JMIR Publications Inc.
- Published
- 2024-06-14
- Volume
- 13
- Pages
- e63176-e63176
- ISSN
- 1929-0748 (ISSN-L)
- PMC
- PMC11496927
- OpenAlex
- W4403204908
- Cited by
- 18
- References
- 82
- Citations by year
- 2026: 9 · 2025: 9
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- JMIR Research Protocols (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Edinburgh Napier Research Repository (Edinburgh Napier University) (acceptedVersion, cc-by)
- Document Server@UHasselt (UHasselt) (submittedVersion, cc-by)
- Lirias (KU Leuven) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by-nc-nd)
- VU Research Portal (submittedVersion, other-oa)
- Funders
- European Commission (964827, 857560, HORIZON2020)
- RECETOX Přírodovědecké Fakulty Masarykovy Univerzity (857560)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- micro- and nanoplastics, prenatal exposure, pregnancy, early life, placenta, polymer additives, maternal and child health, placental function, immune-inflammatory response, oxidative stress, accelerated aging, endocrine disruption, child growth and development, risk assessment, exposure assessment, birth cohort, plastic pollution, AURORA project
- MeSH terms
- Microplastics, Adult, Female, Humans, Pregnancy, Risk Assessment, Maternal Exposure, Nanoparticles
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