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Cited by 486

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Xpert ® MTB/RIF Assay: Development, Evaluation and Implementation of a New Rapid Molecular Diagnostic for Tuberculosis and Rifampicin Resistance

Open access
Lawn, Stephen D, Nicol, Mark P·2011·Future Microbiology
DOI 10.2217/fmb.11.84
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Abstract

Global TB control efforts have been severely hampered by the lack of diagnostic tests that are accurate, simple to use and can be applied at the point of clinical care. This has been further compounded by the widespread inability to test for drug resistance. The Xpert(®) MTB/RIF assay is a rapid molecular assay that can be used close to the point of care by operators with minimal technical expertise, enabling diagnosis of TB and simultaneous assessment of rifampicin resistance to be completed within 2 h. Moreover, this can be accomplished using unprocessed sputum samples as well as clinical specimens from extrapulmonary sites. We review in detail the development of this assay, its evaluation within the laboratory, its utility among adult and pediatric TB suspects, its use as a screening tool for HIV-associated TB and studies of its implementation at the district and sub-district levels in resource-limited settings. Following endorsement by the WHO in 2010, we consider the next steps in the implementation of the assay and its potential impact in high burden settings.

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Research works printed but not linked: 38

  1. 10.1016/S0140-6736(10)62173-3 · DOI · Paper page
  2. 10.1016/S0140-6736(10)60410-2 · DOI · Paper page
  3. 10.1016/j.ccm.2009.08.016 · DOI
  4. 10.1056/NEJMe1008496 · DOI · Paper page
  5. 10.1038/nbt0498-359 · DOI · Paper page
  6. 10.1128/AAC.44.1.103-110.2000 · DOI · Paper page
  7. 10.1128/JCM.39.11.4131-4137.2001 · DOI · Paper page
  8. 10.1128/JCM.01463-09 · DOI · Paper page
  9. 10.1128/JCM.01053-10 · DOI
  10. 10.1016/S0140-6736(11)60438-8 · DOI · Paper page
  11. 10.1136/thx.2005.054908 · DOI · Paper page
  12. 10.1371/journal.pone.0001536 · DOI · Paper page
  13. 10.1186/1471-2334-4-6 · DOI · Paper page
  14. 10.1097/COH.0b013e32832c7d61 · DOI · Paper page
  15. 10.1128/CMR.8.4.496 · DOI · Paper page
  16. 10.1073/pnas.94.18.9869 · DOI · Paper page
  17. 10.1038/nbt0396-303 · DOI · Paper page
  18. 10.1038/nbt0198-49 · DOI · Paper page
  19. 10.1111/j.1365-2672.2006.02810.x · DOI
  20. 10.1164/ajrccm.161.4.16141 · DOI · Paper page
  21. 10.1128/JCM.02214-10 · DOI · Paper page
  22. 10.1128/JCM.01831-10 · DOI · Paper page
  23. 10.5588/ijtld.10.0574 · DOI
  24. 10.1016/S1473-3099(11)70167-0 · DOI · Paper page
  25. 10.2471/BLT.09.062893 · DOI
  26. 10.1164/rccm.201101-0056OC · DOI · Paper page
  27. Van Rie A , MenezesC, ScottLet al. High yield, sensitivity and specificity of Xpert MTB/RIF for M. tuberculosis detection in fine needle aspirates from HIV-infected TB suspects. Program and abstracts of the 18th Conference on Retroviruses and Opportunistic Infections. Boston, MA, USA. (2011) (Abstract #879).
  28. 10.1371/journal.pmed.1001067 · DOI · Paper page
  29. 10.1093/infdis/jir411 · DOI
  30. 10.1086/656282 · DOI
  31. 10.1097/QAD.0b013e32832e05c8 · DOI
  32. 10.1093/cid/ciq128 · doi:10.1093/cid/ciq128
  33. 10.1371/journal.pone.0013901 · DOI
  34. 10.1016/S0140-6736(10)60483-7 · DOI · Paper page
  35. 10.1073/pnas.0901720106 · DOI · Paper page
  36. 10.1128/JCM.00718-11 · DOI
  37. 10.1128/JCM.00138-11 · DOI
  38. Nicol M. Algorithms for referral to rapid diagnostics for MDR-TB: preliminary outcomes. 41st Union World Conference on Lung Health. International Union Against Tuberculosis and Lung Disease. Berlin Germany November2010. Session #10 http://uwclh.conference2web.com/content/227 (Accessed 2nd February2011)

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Metadata

Authors
Lawn, S. D., & Nicol, M. P.
Venue
Future Microbiology
Publisher
Informa UK Limited
Published
2011-09
Volume
6
Issue
9
Pages
1067-1082
ISSN
  • 1746-0913 (ISSN-L)
  • 1746-0921
DOI
10.2217/fmb.11.84
OpenAlex
W2107554560
Cited by
486
References
7
FWCI
17.22
Type
journal article
Language
en
Open access
green
Funders
MP Nicol has also received funding

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CoChat. (2026). Citation check: Xpert ® MTB/RIF Assay: Development, Evaluation and Implementation of a New Rapid Molecular Diagnostic for Tuberculosis and Rifampicin Resistance. https://app.cochat.ai/papers/10.2217/fmb.11.84
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Lawn, S. D., & Nicol, M. P. (2011). Xpert ® MTB/RIF Assay: Development, Evaluation and Implementation of a New Rapid Molecular Diagnostic for Tuberculosis and Rifampicin Resistance. Future Microbiology. https://doi.org/10.2217/fmb.11.84

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.