The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
The sleep–wake Cycle and Alzheimer’s Disease: What do We know?
Open accessAbstract
Sleep-wake disturbances are a highly prevalent and often disabling feature of Alzheimer's disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated with the extracellular accumulation of the amyloid-β (Aβ) peptide. Evidence from animal and human studies suggests that Aβ pathology may disrupt the sleep-wake cycle, in that as Aβ accumulates, more sleep-wake fragmentation develops. Furthermore, recent research in animal and human studies suggests that the sleep-wake cycle itself may influence Alzheimer's disease onset and progression. Chronic sleep deprivation increases amyloid plaque deposition, and sleep extension results in fewer plaques in experimental models. In this review geared towards the practicing clinician, we discuss possible mechanisms underlying the reciprocal relationship between the sleep-wake cycle and AD pathology and behavior, and present current approaches to therapy for sleep disorders in AD.
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“Agitation is common in Alzheimer's disease, with 60% of people with MCI and 76% of people with Alzheimer's dementia experiencing agitation.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [63]
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In the citing paper
“For example, increases in beta‐amyloid and tau may interrupt the sleep‐wake cycle, 217 leading to increased sleep fragmentation and wakefulness and decreased slow‐wave sleep. 63”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [63]
In the citing paper
“In contrast to SD, enhancing normal sleep patterns may alleviate AD pathogenesis, as extension of sleep duration decreases plaque deposition in animal models [574].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [574]
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Sleep Drives Metabolite Clearance from the Adult Brain
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Clinical and biomarker changes in dominantly inherited Alzheimer's disease
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Self-citationAmyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
Self-citationAlzheimer’s Disease: The Challenge of the Second Century
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Self-citationEEG dynamics in patients with Alzheimer's disease
Jeong, J. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.001 · Cited by 1,400
Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective
Irwin, M. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115205 · Cited by 1,325 · cited 2×
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BackgroundInfluentialSynaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
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Self-citationThe role of sleep in learning and memory
Maquet, P. (2001) · Science · doi:10.1126/science.1062856 · Cited by 1,177
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Research works printed but not linked: 1
- Naylor E , AillonDV, BarrettBSet al. Lactate as a biomarker for sleep . Sleep35 ( 9 ), 1209 – 1222 ( 2012 ).
Cited by
Sorted by citations
2024 Alzheimer's disease facts and figures
(2024) · Alzheimer's & Dementia · doi:10.1002/alz.13809 · Cited by 2,536
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Wang, C., & Holtzman, D. M. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 615
Self-citation2025 Alzheimer's disease facts and figures
(2025) · Alzheimer s & Dementia · doi:10.1002/alz.70235 · Cited by 642
Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
Bellesi, M., de Vivo, L., Chini, M., Gilli, F., Tononi, G., & Cirelli, C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3981-16.2017 · Cited by 431
Metadata
- Authors
- Lim, M. M., Gerstner, J. R., & Holtzman, D. M.
- Affiliations
- Oregon Health & Science University (US)
- Washington State University Spokane (US)
- Washington University in St. Louis (US)
- Venue
- Neurodegenerative Disease Management
- Publisher
- Informa UK Limited
- Published
- 2014-10
- Volume
- 4
- Issue
- 5
- Pages
- 351-362
- ISSN
- 1758-2024 (ISSN-L)
- 1758-2032
- PMC
- PMC4257134
- OpenAlex
- W1984375619
- Cited by
- 168
- References
- 105
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 15 · 2023: 8 · 2022: 20 · 2021: 14 · 2020: 16 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 11 · 2015: 4
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurodegenerative Disease Management (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01 AG0 3991, P01AG003991)
- National Heart, Lung, and Blood Institute (T32HL007713)
- National Institute of Neurological Disorders and Stroke (P01NS080675, 1P01NS074969-A1, P01NS074969)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, sleep-wake cycle, sleep-wake disturbances, amyloid-beta, amyloid plaques, sleep fragmentation, chronic sleep deprivation, sleep extension, disease progression
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Humans, Sleep, Amyloid beta-Peptides, Disease Progression, Sleep Disorders, Circadian Rhythm, Plaque, Amyloid
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