The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Erythrocyte Membrane-Cloaked Polymeric Nanoparticles for Controlled Drug Loading and Release
Abstract
AIM: Polymeric nanoparticles (NPs) cloaked by red blood cell membrane (RBCm) confer the combined advantage of both long circulation lifetime and controlled drug release. The authors carried out studies to gain a better understanding of the drug loading, drug-release kinetics and cell-based efficacy of RBCm-cloaked NPs. MATERIALS & METHODS: Two strategies for loading doxorubicin into the RBCm-cloaked NPs were compared: physical encapsulation and chemical conjugation. In vitro efficacy was examined using the acute myeloid leukemia cell line, Kasumi-1. RESULTS: It was found that the chemical conjugation strategy resulted in a more sustained drug release profile, and that the RBCm cloak provided a barrier, retarding the outward diffusion of encapsulated drug molecules. It was also demonstrated that RBCm-cloaked NPs exhibit higher toxicity in comparison with free doxorubicin. CONCLUSION: These results indicate that the RBCm-cloaked NPs hold great promise to become a valuable drug-delivery platform for the treatment of various diseases such as blood cancers.
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Nanocarriers as an emerging platform for cancer therapy
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Nanoparticle therapeutics: an emerging treatment modality for cancer
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Factors affecting the clearance and biodistribution of polymeric nanoparticles
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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
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Cited by
Cell Membrane Coating Nanotechnology
Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L. (2018) · Advanced Materials · doi:10.1002/adma.201706759 · Cited by 1,885
Self-citationTargeting drugs to tumours using cell membrane-coated nanoparticles
Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980
Self-citationXia, Q., Zhang, Y., Li, Z., Hou, X., & Feng, N. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.01.011 · Cited by 665
Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors
Sun, H., Su, J., Meng, Q., Yin, Q., Chen, L., Gu, W., Zhang, P., Zhang, Z., Yu, H., Wang, S., et al. (2016) · Advanced Materials · doi:10.1002/adma.201602173 · Cited by 640
Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy
Zhen, X., Cheng, P., & Pu, K. (2019) · Small · doi:10.1002/smll.201804105 · Cited by 483
Metadata
- Authors
- Aryal, S., Hu, C.-M. J., Fang, R. H., Dehaini, D., Carpenter, C., Zhang, D.-E., & Zhang, L.
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2013-08
- Volume
- 8
- Issue
- 8
- Pages
- 1271-1280
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W2151138870
- Cited by
- 214
- References
- 5
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Aryal, S., Hu, C.-M. J., Fang, R. H., Dehaini, D., Carpenter, C., Zhang, D.-E., & Zhang, L. (2013). Erythrocyte Membrane-Cloaked Polymeric Nanoparticles for Controlled Drug Loading and Release. Nanomedicine. https://doi.org/10.2217/nnm.12.153
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