The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man
Open accessAbstract
There is a growing socio-economic need for effective strategies to repair damaged bone resulting from disease, trauma and surgical intervention. Bone tissue engineering has received substantial investment over the last few decades as a result. A multitude of studies have sought to examine the efficacy of multiple growth factors, delivery systems and biomaterials within in vivo animal models for the repair of critical-sized bone defects. Defect repair requires recapitulation of in vivo signalling cascades, including osteogenesis, chondrogenesis and angiogenesis, in an orchestrated spatiotemporal manner. Strategies to drive parallel, synergistic and consecutive signalling of factors including BMP-2, BMP-7/OP-1, FGF, PDGF, PTH, PTHrP, TGF-β3, VEGF and Wnts have demonstrated improved bone healing within animal models. Enhanced bone repair has also been demonstrated in the clinic following European Medicines Agency and Food and Drug Administration approval of BMP-2, BMP-7/OP-1, PDGF, PTH and PTHrP. The current review assesses the in vivo and clinical data surrounding the application of growth factors for bone regeneration. This review has examined data published between 1965 and 2013. All bone tissue engineering studies investigating in vivo response of the growth factors listed above, or combinations thereof, utilising animal models or human trials were included. All studies were compiled from PubMed-NCBI using search terms including 'growth factor name', 'in vivo', 'model/animal', 'human', and 'bone tissue engineering'. Focus is drawn to the in vivo success of osteoinductive growth factors incorporated within material implants both in animals and humans, and identifies the unmet challenges within the skeletal regenerative area.
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Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904
Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration
Tang, D., Tare, R. S., Yang, L.-Y., Williams, D. F., Ou, K.-L., & Oreffo, R. O. C. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.024 · Cited by 613
Self-citationTenkumo, T., Vanegas Sáenz, J. R., Nakamura, K., Shimizu, Y., Sokolova, V., Epple, M., Kamano, Y., Egusa, H., Sugaya, T., & Sasaki, K. (2018) · Materials Science and Engineering: C · doi:10.1016/j.msec.2018.06.047 · Cited by 46
Xiang, C., Tenkumo, T., Ogawa, T., Kanda, Y., Nakamura, K., Shirato, M., Sokolova, V., Epple, M., Kamano, Y., Egusa, H., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.11.003 · Cited by 15
Metadata
- Authors
- Bone and Joint Research Group, H. D. A. H., Gothard, D., Smith, E., Kanczler, J., Rashidi, H., Qutachi, O., Henstock, J., Rotherham, M., El Haj, A., Shakesheff, K., & Oreffo, R.
- Venue
- European Cells and Materials
- Publisher
- Forum Multimedia Publishing LLC
- Published
- 2014-10-06
- Volume
- 28
- Pages
- 166-208
- ISSN
- 1473-2262 (ISSN-L)
- OpenAlex
- W2164321850
- Cited by
- 188
- References
- 10
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man. https://app.cochat.ai/papers/10.22203/ecm.v028a13
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- Bone and Joint Research Group, H. D. A. H., Gothard, D., Smith, E., Kanczler, J., Rashidi, H., Qutachi, O., Henstock, J., Rotherham, M., El Haj, A., Shakesheff, K., & Oreffo, R. (2014). Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man. European Cells and Materials. https://doi.org/10.22203/ecm.v028a13
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
