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Cited by 887

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid

Buettner, Garry R., Jurkiewicz, Beth Anne·1996·Radiation Research
DOI 10.2307/3579271
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Abstract

Trace levels of transition metals can participate in the metal-catalyzed Haber-Weiss reaction (superoxide-driven Fenton reaction) as well as catalyze the oxidation of ascorbate. Generally ascorbate is thought of as an excellent reducing agent; it is able to serve as a donor antioxidant in free radical-mediated oxidation processes. However, as a reducing agent it is also able to reduce redox-active metals such as copper and iron, thereby increasing the pro-oxidant chemistry of these metals. Thus ascorbate can serve as both a pro-oxidant and an antioxidant. In general, at low ascorbate concentrations, ascorbate is prone to be a pro-oxidant, and at high concentrations, it will tend to be an antioxidant. Hence there is a crossover effect. We propose that the "position" of this crossover effect is a function of the catalytic metal concentration. In this presentation, we discuss: (1) the role of catalytic metals in free radical-mediated oxidations; (2) ascorbate as both a pro-oxidant and an antioxidant; (3) catalytic metal catalysis of ascorbate oxidation; (4) use of ascorbate to determine adventitious catalytic metal concentrations; (5) use of ascorbate radical as a marker of oxidative stress; and (6) use of ascorbate and iron as free radical pro-oxidants in photodynamic therapy of cancer.

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Metadata

Authors
Buettner, G. R., & Jurkiewicz, B. A.
Venue
Radiation Research
Publisher
JSTOR
Published
1996-05
Volume
145
Issue
5
Pages
532
ISSN
0033-7587 (ISSN-L)
DOI
10.2307/3579271
OpenAlex
W2165890143
Cited by
887
References
60
FWCI
13.64
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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