The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Image-Guided Surgery Using Invisible Near-Infrared Light: Fundamentals of Clinical Translation
Open accessAbstract
The field of biomedical optics has matured rapidly over the last decade and is poised to make a significant impact on patient care. In particular, wide-field (typically > 5 cm), planar, near-infrared (NIR) fluorescence imaging has the potential to revolutionize human surgery by providing real-time image guidance to surgeons for tissue that needs to be resected, such as tumors, and tissue that needs to be avoided, such as blood vessels and nerves. However, to become a clinical reality, optimized imaging systems and NIR fluorescent contrast agents will be needed. In this review, we introduce the principles of NIR fluorescence imaging, analyze existing NIR fluorescence imaging systems, and discuss the key parameters that guide contrast agent development. We also introduce the complexities surrounding clinical translation using our experience with the Fluorescence-Assisted Resection and Exploration (FLARE™) imaging system as an example. Finally, we introduce state-of-the-art optical imaging techniques that might someday improve image-guided surgery even further.
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Cites
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Cited by
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Schaafsma, B. E., Mieog, J. S. D., Hutteman, M., van der Vorst, J. R., Kuppen, P. J. K., Löwik, C. W. G. M., Frangioni, J. V., van de Velde, C. J. H., & Vahrmeijer, A. L. (2011) · Journal of Surgical Oncology · doi:10.1002/jso.21943 · Cited by 816
Self-citationTargeted zwitterionic near-infrared fluorophores for improved optical imaging
Choi, H. S., Gibbs, S. L., Lee, J. H., Kim, S. H., Ashitate, Y., Liu, F., Hyun, H., Park, G., Xie, Y., Bae, S., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2468 · Cited by 560
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Theranostic Fluorescent Probes
Sharma, A., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J.-H., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 499
Metadata
- Authors
- Gioux, S., Choi, H. S., & Frangioni, J. V.
- Venue
- Molecular Imaging
- Publisher
- SAGE Publications
- Published
- 2010-09-01
- Volume
- 9
- Issue
- 5
- Pages
- 237-55
- ISSN
- 1535-3508 (ISSN-L)
- 1536-0121
- OpenAlex
- W4297705338
- Cited by
- 599
- References
- 85
- FWCI
- 24.35
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gioux, S., Choi, H. S., & Frangioni, J. V. (2010). Image-Guided Surgery Using Invisible Near-Infrared Light: Fundamentals of Clinical Translation. Molecular Imaging. https://doi.org/10.2310/7290.2010.00034
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