The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
Open accessAbstract
BACKGROUND: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population. METHODS: In an open trial, we gave Bifidobacterium breve M-16V and Bifidobacterium longum BB536 prenatally to 130 mothers beginning 1 month prior to delivery and postnatally to their infants for 6 months. Another 36 mother-infant pairs served as controls and did not receive the bifidobacterial supplementation. Development of allergic symptoms in the infants was assessed at 4, 10 and 18 months of age. Fecal samples were collected from the mothers and infants. RESULTS: The risk of developing eczema/atopic dermatitis (AD) during the first 18 months of life was significantly reduced in infants in the probiotic group (OR: 0.231 [95% CI: 0.084-0.628] and 0.304 [0.105-0.892] at 10 and 18 months of age, respectively). Pyrosequencing analyses indicated an altered composition of the fecal microbiota at 4 months for infants who developed eczema/AD at 4 and 10 months of age. The proportion of Proteobacteria was significantly lower (P = 0.007) in mothers at the time of delivery who received the supplementation when compared with the control group and was positively correlated (r = 0.283, P = 0.024) with that of infants at 4 months of age. No adverse effects were related to the use of probiotics. CONCLUSIONS: These data suggest that the prenatal and postnatal supplementation of bifidobacteria is effective in primary preventing allergic diseases. Some limited changes in the composition of fecal microbiota by the bifidobacterial supplementation were observed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In vitro and in vivo studies have shown that modulating bifidobacterial levels through probiotic or prebiotic supplementation can change the overall composition and metabolism of the gut microbiota (49–53).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,144
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,443
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255
Allergy development and the intestinal microflora during the first year of life
Björkstén, B., Sepp, E., Julge, K., Voor, T., & Mikelsaar, M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118130 · Cited by 1,203
The intestinal microflora in allergic Estonian and Swedish 2‐year‐old children
Björkstén, Naaber, P., Sepp, & Mikelsaar (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00560.x · Cited by 927
Penders, J., Thijs, C., van den Brandt, P. A., Kummeling, I., Snijders, B., Stelma, F., Adams, H., van Ree, R., & Stobberingh, E. E. (2007) · Gut · doi:10.1136/gut.2006.100164 · Cited by 844
Cited by
Sorted by citations
Items 101–165 of 165
Probiotics: Origin, Products, and Regulations in India
Narula, A. (2021) · Microorganisms for Sustainability · doi:10.1007/978-981-16-1947-2_4 · Cited by 6
Overlapping features of atopic dermatitis and alopecia areata: from pathogenesis to treatment
Cheng, J., Jiang, Y., Chen, Q., & Xiao, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1641918 · Cited by 7
Mao, H., Li, S., Yin, B., Lin, X., Guo, J., Wang, T., Voglmeir, J., & Liu, L. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132532 · Cited by 6
Shedding light on key pharmacological knowledge and strategies for pediatric atopic dermatitis
Moreno, A., Renert‐Yuval, Y., & Guttman‐Yassky, E. (2023) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2023.2173172 · Cited by 6
Toh, M. P. S., Yang, C. Y., Lim, P. C., Loh, H. L. J., Bergonzelli, G. E., Lavalle, L., Mardhy, E., Samuel, T. M., Suniega-Tolentino, E., Zolezzi, I. S., et al. (2023) · JMIR Research Protocols · doi:10.2196/41751 · Cited by 8
Hu, Y., Hong, H., Zhou, J., Cui, Y., Zhang, B., & Zhao, J. (2023) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-023-03770-6 · Cited by 6
Gut microbiota in infants with food protein enterocolitis
Xiong, J., Ma, Y.-J., Liao, X.-S., Li, L.-Q., & Bao, L. (2024) · Pediatric Research · doi:10.1038/s41390-024-03424-9 · Cited by 6
Probiotics and allergic diseases
Akelma, A. Z., & Topçu, Z. İ. K. (2016) · World Journal of Immunology · doi:10.5411/wji.v6.i1.75 · Cited by 6
Li, Y., Jing, D., Huang, Y., Su, J., Li, J., Li, J., Tao, J., Shan, S., Wang, X., Kang, X., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-047768 · Cited by 7
Probiotics as Curators of a Healthy Gut Microbiota
Murphy, A., Dinan, T. G., Cryan, J. F., Stanton, C., & Ross, R. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00005-0 · Cited by 6
Research status and development trends of probiotics in clinical applications
Li, Y., Yao, Y., Zhang, Z., & Gan, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1650883 · Cited by 6
Welp, A., Laser, E., Seeger, K., Haiß, A., Hanke, K., Faust, K., Stichtenoth, G., Fortmann-Grote, C., Pagel, J., Rupp, J., et al. (2024) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-024-00179-5 · Cited by 5
Gut-Skin Axis: Role in Health and Disease
Malaviya, A., Krishna, K. V., Malviya, S., & Das, T. (2021) · Springer eBooks · doi:10.1007/978-981-16-5628-6_1 · Cited by 5
Prebiotics, Probiotics, and Synbiotics: A Bifidobacterial View
Morelli, L., Callegari, M. L., & Patrone, V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805060-6.00017-x · Cited by 6
The effect of consuming fermented milk containing probiotics during pregnancy
Fitria, N., Lailaturrahmi, L., & Sukma, A. (2024) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/1341/1/012032 · Cited by 4
Bifidobacterium for Infants: Essence and Efficacy
Lau, A. S.-Y., Xiao, J., & Liong, M. (2015) · Microbiology monographs · doi:10.1007/978-3-319-23213-3_3 · Cited by 4
Self-citationThinbanmai, T., Lulitanond, V., Mayo, B., Lulitanond, A., & Panya, M. (2018) · Letters in Applied Microbiology · doi:10.1111/lam.13089 · Cited by 4
Bifidobacteria in disease: from head to toe
Zhang, W., Jia, Q., Han, M., Zhang, X., Guo, L., Sun, S., Yin, W., Bo, C., Han, R., & Sai, L. (2023) · Folia Microbiologica · doi:10.1007/s12223-023-01087-3 · Cited by 4
Quigley, E. M. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00015-x · Cited by 4
Inaba, Y., Furukawa, F., Azuma, S., Baba, K., Taniguchi, M., & Murakami, Y. (2020) · Trends in Immunotherapy · doi:10.24294/ti.v4.i1.1230 · Cited by 4
Self-citationBifidobacterium breve during infancy attenuates mobility in low birthweight rats
Itoh, A., Tanaka, N., Fukunaga, S., Nakano‐Doi, A., Matsuyama, T., Nakagomi, T., & Tsuji, M. (2022) · Pediatrics International · doi:10.1111/ped.15209 · Cited by 4
Anti-inflammatory effects of probiotics
Prado, M. R. M., & Boller, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816992-6.00009-7 · Cited by 4
Non-pharmacological therapies and their efficacy in atopic dermatitis: A narrative review
Hemalatha, M., Dev, A., Mahajan, R., De, D., & Handa, S. (2025) · Indian Journal of Dermatology Venereology and Leprology · doi:10.25259/ijdvl_1076_2024 · Cited by 5
Gut microbiome: Current development, challenges, and perspectives
Purkait, D., Hameed, S., & Fatima, Z. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820528-0.00016-8 · Cited by 3
Probiotics in the Prevention of Infant Infection
Chaturvedi, S., Gokhale, J. S., & Chakraborty, S. (2021) · Springer eBooks · doi:10.1007/978-981-33-6236-9_3 · Cited by 3
The new era of immune skin diseases: Exploring advances in basic research and clinical translations
Zhang, B., Mei, X., Zhao, M., & Lu, Q. (2024) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2024.100232 · Cited by 4
The use of essential oils in atopic dermatitis: a review
Azhari, H., Ng, S., Razali, R. M., & Loo, H. L. (2024) · Current Medical Research and Opinion · doi:10.1080/03007995.2024.2340734 · Cited by 4
Early Life Microbiota—Impact of Delivery Mode and Infant Feeding
Ouyang, R., Korpela, K., Liu, X., Xu, G., de Vos, W. M., & Kovatcheva‐Datchary, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00064-4 · Cited by 3
Chandrashekar, B., Agarwal, R., Nayak, P. B., Vijayraghavan, S., & Deshmukh, A. (2020) · International Journal of Research in Dermatology · doi:10.18203/issn.2455-4529.intjresdermatol20203071 · Cited by 3
Probiotic Effects on Skin Health: The Case of Photoprotection as a Model of Gut-Skin Dialog
Maglio, D. H. G., Friedrich, A. D., Cela, E., Paz, M. L., & Leoni, J. (2021) · Springer eBooks · doi:10.1007/978-981-16-5628-6_7 · Cited by 3
Ov, B., Andryuschenko, S. V., Nb, P., Ev, I., In, C., & Александровна, З. И. (2019) · Data in Brief · doi:10.1016/j.dib.2019.104761 · Cited by 3
Role of 70 °C heating on immunostimulatory effects of probiotic bifidobacteria in infant formula
Sen, A., Ishihara, S., Ando, M., Kaneko, H., Mishima, R., Nishimura, T., Hishida, Y., Tanaka, M., Takeyama, H., & Odamaki, T. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117846 · Cited by 2
Self-citationChapter 17 Safety of probiotics in infants and children
van den Nieuwboer, M., Browne, P. D., & Claassen, E. (2017) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-839-1_17 · Cited by 2
Diehl, C. (2019) · Ukrainian Journal of Dermatology Venerology Cosmetology · doi:10.30978/ujdvk2019-2-99 · Cited by 2
Probiotics for Atopic Dermatitis: An Update
Kakade, P., Wairkar, S., Lohakare, S., Shah, P., & Patravale, V. B. (2021) · Springer eBooks · doi:10.1007/978-981-16-5628-6_9 · Cited by 2
Evidências científicas sobre a modulação da microbiota intestinal nas alergias alimentares
Sousa, G. D. M., & Landim, L. A. D. S. R. (2022) · Research Society and Development · doi:10.33448/rsd-v11i15.37571 · Cited by 3
Bifidobacteria spp. As a Potential Probiotic for the Treatment of Various Diseases
Eya, C. P., Eya, I. E., & Ebhodaghe, F. E. (2024) · Journal of applied science and environmental management · doi:10.4314/jasem.v28i5.31 · Cited by 3
An orthodontic appliance used in management of lingual focal dystonia.
Illing, H., & Robinson, S. (1999) · PubMed · Cited by 1
Samayoa, J. A. M., Benítez, L. E. H., Joya, M. G. V., & Meléndez, Z. G. G. (2022) · ALERTA Revista Científica del Instituto Nacional de Salud · doi:10.5377/alerta.v5i1.12563 · Cited by 1
Mikrobiota usus pada dermatitis atopik
Gotama, D., Wardhana, M., Santoso, A., & Sissy, S. (2021) · Intisari Sains Medis · doi:10.15562/ism.v12i2.994 · Cited by 1
Probiotics in Allergy Prevention
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_4 · Cited by 1
Clinical Significance of Bifidobacteria
Riedel, C. U. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805060-6.00013-2 · Cited by 3
Lactobacillus plantarum 由来菌体表層グリセルアルデヒド-3-リン酸脱水素酵素の結晶構造解析：水銀結合メカニズムの解明
Yoneda, K., 緒方, 美., 西山, 啓., 福田, 健., 安田, 伸., 井越, 敬., & 英樹, 木. (2019) · ミルクサイエンス · doi:10.11465/milk.68.3 · Cited by 1
Probiotics for Atopic Dermatitis
Khanna, N., Devi, P., Kumar, A., & Pawar, S. V. (2021) · Springer eBooks · doi:10.1007/978-981-33-6236-9_15 · Cited by 1
Förster, U. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-16505
New Features of Systemic Vasculitides
Yamaguchi, M., & Izuhara, K. (2014) · Allergology International · doi:10.2332/allergolint.14-ed-0832
Yang, S. (2015) · TSpace (University of Toronto)
Bifidobacterial enzymes acting on human-derived glycans
Katayama, T. (2016) · Japanese Journal of Lactic Acid Bacteria · doi:10.4109/jslab.27.17
Intervention of allergic disorders by bifidobacteria
Enomoto, T., & Xiao, J. (2015) · 耳鼻咽喉科免疫アレルギー · doi:10.5648/jjiao.33.231
Self-citationCanani, R. B., Gilbert, J. A., & Nagler‐Anderson, C. (2015)
The human microbiome and role of probiotics in the prevention of atopic dermatitis
Wang, J. (2019) · Nihon Shoni Arerugi Gakkaishi The Japanese Journal of Pediatric Allergy and Clinical Immunology · doi:10.3388/jspaci.33.26
Comprehensive analysis of microbes and metabolites in human tear fluids
村上, 慎., 馬場, 藤., Aw, W., 福田, 真., 曽我, 朋., 藤島, 浩., & 冨田, 勝. (2015) · Institutional Repositories DataBase (IRDB) · doi:10.14991/003.00150001-0382
Peran Bifidobakteria dalam Pencegahan dan Pengobatan Alergi serta Gangguan Sistem Imun pada Anak
Wati, K. D. K., & Setiabudiawan, B. (2021) · Sari Pediatri · doi:10.14238/sp22.6.2021.394-400
Al-shami, S. J., Şandru, F., Dumitrașcu, M. C., & Popa, A. (2022) · Romanian Journal of Military Medicine · doi:10.55453/rjmm.2022.125.3.19
Tsuji, M., Tanaka, N., Koike, H., Sato, Y., Shimoyama, Y., & Itoh, A. (2023) · Life · doi:10.3390/life13102005
The impact of human milk oligosaccharides on infant gastrointestinal microbiota and immune function
Liao, Y., Sun, F., & Ying, Y. (2024) · International Conference on Biological Engineering and Medical Science (ICBioMed) · doi:10.1117/12.3012916
Unravelling the Complexities and Recent Advances in the Management of Atopic Dermatitis
Pandey, V. P., Punniyamoorthy, S., Pradhan, S., Umar, M., Bano, U., Pokharel, Y. R., Karwasra, R., Umar, T., & Kumar, P. (2024) · Current Drug Therapy · doi:10.2174/0115748855299561240802111649
Microbiome in Patients with Atopic Dermatitis
Rehbinder, E. M., Rapin, A., & Ubags, N. D. J. (2025) · Springer eBooks · doi:10.1007/978-3-031-82689-4_6
McNeece, M. (2025) · Journal of Dermatology for Physician Assistants · doi:10.1097/jdpa.0000000000000082
Probióticos: Um guia prático de prescrição personalizada
Ribeiro, F. L. E., Ascenso, A., Landeiro, J., Miranda, J. V., Crespo, S., & Pinto, R. (2025) · Research Society and Development · doi:10.33448/rsd-v14i11.50174
Autoimmune Protocol Diet (AIP) for Food Allergies: A Novel Immunonutrition Approach
Pardali, E. C., & Grammatikopoulou, M. G. (2026) · Applied Sciences · doi:10.3390/app16031364
Su, Z., Huang, Z., Huang, Y. Q., Guo, J., Wang, Q., Xu, S., Kang, Y., Wang, Z., Shi, Y., & Jia, B. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108318 · Cited by 1
Asato, Y., Kubo, T., Hashimoto, M., Wakatsuki, T., Sakamoto, H., Tanigawa, T., Kitamura, S., & Kadokawa, H. (2026) · Reproduction Fertility and Development · doi:10.1071/rd26107
Molecular mechanisms involved in the anticancer activities of probiotics and postbiotics
Rocchetti, M. T., Mangieri, D., Spano, G., & Fiocco, D. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04411-2
Salivary OMICS factors associated with atopic dermatitis in early infancy
Alomeir, N., Chinchilli, E., Terio, C., Zhang, L., Beck, L. A., Assery, N. M., Mao, X., Wolf, J. R., Xiao, J., & Wu, T. T. (2026) · Pediatric Allergy and Immunology · doi:10.1111/pai.70468
Self-citation
Metadata
- Authors
- Enomoto, T., Sowa, M., Nishimori, K., Shimazu, S., Yoshida, A., Yamada, K., Furukawa, F., Nakagawa, T., Yanagisawa, N., Iwabuchi, N., Odamaki, T., Abe, F., Nakayama, J., & Xiao, J.-Z.
- Affiliations
- Hidaka Hospital (JP)
- Japanese Red Cross Society Wakayama Medical Center (JP)
- Wakayama Medical University (JP)
- Morinaga Milk Industry Co., Ltd. (Japan) (JP)
- Kyushu University (JP)
- Corresponding author
- Enomoto, Tadao
- ORCID
- Venue
- Allergology International
- Publisher
- Japanese Society of Allergology
- Published
- 2014
- Volume
- 63
- Issue
- 4
- Pages
- 575-585
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2000251859
- Cited by
- 165
- References
- 43
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 13 · 2023: 10 · 2022: 20 · 2021: 22 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 12 · 2016: 14 · 2015: 14 · 2014: 2
- FWCI
- 20.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Allergology International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Morinaga Milk Industry
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium, probiotics, Bifidobacterium breve M-16V, Bifidobacterium longum BB536, infant allergy prevention, atopic dermatitis, fecal microbiota, Proteobacteria, maternal gut microbiota, Japanese infants
- MeSH terms
- Adult, Bifidobacterium, Feces, Female, Humans, Hypersensitivity, Infant, Male, Patient Compliance, Pregnancy, Prevalence, Odds Ratio, Probiotics, Biodiversity, Young Adult, Metagenomics, High-Throughput Nucleotide Sequencing, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
