The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota
Open accessAbstract
BACKGROUND: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population. METHODS: In an open trial, we gave Bifidobacterium breve M-16V and Bifidobacterium longum BB536 prenatally to 130 mothers beginning 1 month prior to delivery and postnatally to their infants for 6 months. Another 36 mother-infant pairs served as controls and did not receive the bifidobacterial supplementation. Development of allergic symptoms in the infants was assessed at 4, 10 and 18 months of age. Fecal samples were collected from the mothers and infants. RESULTS: The risk of developing eczema/atopic dermatitis (AD) during the first 18 months of life was significantly reduced in infants in the probiotic group (OR: 0.231 [95% CI: 0.084-0.628] and 0.304 [0.105-0.892] at 10 and 18 months of age, respectively). Pyrosequencing analyses indicated an altered composition of the fecal microbiota at 4 months for infants who developed eczema/AD at 4 and 10 months of age. The proportion of Proteobacteria was significantly lower (P = 0.007) in mothers at the time of delivery who received the supplementation when compared with the control group and was positively correlated (r = 0.283, P = 0.024) with that of infants at 4 months of age. No adverse effects were related to the use of probiotics. CONCLUSIONS: These data suggest that the prenatal and postnatal supplementation of bifidobacteria is effective in primary preventing allergic diseases. Some limited changes in the composition of fecal microbiota by the bifidobacterial supplementation were observed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In vitro and in vivo studies have shown that modulating bifidobacterial levels through probiotic or prebiotic supplementation can change the overall composition and metabolism of the gut microbiota (49–53).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,144
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,443
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255
Allergy development and the intestinal microflora during the first year of life
Björkstén, B., Sepp, E., Julge, K., Voor, T., & Mikelsaar, M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118130 · Cited by 1,203
The intestinal microflora in allergic Estonian and Swedish 2‐year‐old children
Björkstén, Naaber, P., Sepp, & Mikelsaar (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00560.x · Cited by 927
Penders, J., Thijs, C., van den Brandt, P. A., Kummeling, I., Snijders, B., Stelma, F., Adams, H., van Ree, R., & Stobberingh, E. E. (2007) · Gut · doi:10.1136/gut.2006.100164 · Cited by 844
Kukkonen, A. K., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., & Kuitunen, M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.09.009 · Cited by 708
Nobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653
McNulty, N. P., Yatsunenko, T., Hsiao, A., Faith, J. J., Muegge, B. D., Goodman, A. L., Henrissat, B., Oozeer, R., Cools-Portier, S., Gobert, G., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002701 · Cited by 559
Abrahamsson, T., Jakobsson, T., Böttcher, M. F., Fredrikson, M. G., Jenmalm, M. C., Björkstén, B., & Oldæus, G. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.01.007 · Cited by 476
Wickens, K. L., Black, P., Stanley, T., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.07.011 · Cited by 432
Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects
Watanabe, S., NARISAWA, Y., Arase, S., OKAMATSU, H., Ikenaga, T., Tajiri, Y., & Kumemura, M. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.105 · Cited by 392
Rautava, S., Collado, M. C., Salminen, S., & Isolauri, E. (2012) · Neonatology · doi:10.1159/000339182 · Cited by 297
Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial
Dotterud, C. K., Storrø, O., Johnsen, R., & Øien, T. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09889.x · Cited by 296
Probiotics Supplementation During Pregnancy or Infancy for the Prevention of Atopic Dermatitis
Pelucchi, C., Chatenoud, L., Turati, F., Galeone, C., Moja, L., Bach, J., & Vecchia, C. L. (2012) · Epidemiology · doi:10.1097/ede.0b013e31824d5da2 · Cited by 281
Rautava, S., Kainonen, E., Salminen, S., & Isolauri, E. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.09.003 · Cited by 273
Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials
Elazab, N., Mendy, A., Gasana, J., Vieira, E. R., Quizon, A., & Forno, E. (2013) · PEDIATRICS · doi:10.1542/peds.2013-0246 · Cited by 269
Boyle, R. J., Ismail, I. H., Kivivuori, S., Licciardi, P. V., Robins-Browne, R. M., Mah, L. ‐., Axelrad, C. M., Moore, S., Donath, S. M., Carlin, J. B., et al. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02507.x · Cited by 228
He, F., Ouwehand, A. C., Isolauri, E., Hashimoto, H., Benno, Y., & Salminen, S. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb01548.x · Cited by 220
Epidemiology of atopic dermatitis
Williams, H. C. (2000) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2000.00698.x · Cited by 216
Probiotics during weaning reduce the incidence of eczema
West, C. E., Hammarström, M., & Hernell, O. (2009) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2009.00745.x · Cited by 179
Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis
van der Aa, L. B., van Aalderen, W. M. C., Heymans, H. S. A., Henk Sillevis Smitt, J., Nauta, A. J., Knippels, L. M. J., Ben Amor, K., Sprikkelman, A. B., & the Synbad Study Group (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02416.x · Cited by 172
Probiotics in the treatment of Japanese cedar pollinosis: a double‐blind placebo‐controlled trial
Xiao, J., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Miyaji, K., Iwatsuki, K., Togashi, H., Enomoto, K., et al. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02575.x · Cited by 163
Self-citationEffect of a new synbiotic mixture on atopic dermatitis in infants: a randomized‐controlled trial
van der Aa, L. B., Heymans, H. S. A., van Aalderen, W. M. C., Smitt, J. H. S., Knol, J., Amor, K. B., Goossens, D. A. M., Sprikkelman, A. B., & the Synbad Study Group (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03465.x · Cited by 160
Atopic Dermatitis in Infants and Children
Hanifin, J. M. (1991) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)38153-6 · Cited by 152
Intestinal microbiota and immunoglobulin E responses in 5‐year‐old Estonian children
Sepp, E., Julge, K., Mikelsaar, M., & Björkstén, B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02315.x · Cited by 131
Larsen, C. N., Nielsen, S., Kæstel, P., Brockmann, E., Bennedsen, M., Christensen, H. R., Eskesen, D. C., Jacobsen, B. L., & Michaelsen, K. F. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602450 · Cited by 124
Xiao, J., Kondo, S., Yanagisawa, N., Takahashi, N., Odamaki, T., Iwabuchi, N., Iwatsuki, K., Kokubo, S., Togashi, H., Enomoto, K., et al. (2006) · PubMed · Cited by 123
Self-citationMurray, C. S., Tannock, G. W., Simon, M. A., Harmsen, H. J. M., Welling, G. W., Čustović, A., & Woodcock, A. A. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02259.x · Cited by 104
Distinct Pattern of Commensal Gut Microbiota in Toddlers with Eczema
Mah, K. W., Björkstén, B., Lee, B. W., Bever, H. P. V., Shek, L. P., Tan, T. N., Lee, Y. K., & Chua, K. Y. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000092555 · Cited by 101
Ou, C. ‐., Kuo, H., Wang, L., Hsu, T. ‐., Chuang, H., Liu, C. ‐., Chang, J., Yu, H., & Yang, K. D. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.04037.x · Cited by 91
Nakayama, J., Kobayashi, T., Tanaka, S., Korenori, Y., Tateyama, A., Sakamoto, N., Kiyohara, C., Shirakawa, T., & Sonomoto, K. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00872.x · Cited by 88
Self-citationXiao, J., Kondo, S., Yanagisawa, N., Miyaji, K., Enomoto, K., Sakoda, T., Iwatsuki, K., & Enomoto, T. (2007) · Allergology International · doi:10.2332/allergolint.o-06-455 · Cited by 73
Self-citationSuzuki, S., Shimojo, N., Tajiri, Y., Kumemura, M., & Kohno, Y. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02676.x · Cited by 66
Inoue, Y., Iwabuchi, N., Xiao, J., Yaeshima, T., & Iwatsuki, K. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.760 · Cited by 60
Self-citationImpact of Diet on the Intestinal Microbiota in 10‐month‐old Infants
Nielsen, S., Nielsen, D. S., Lauritzen, L., Jakobsen, M., & Michaelsen, K. F. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3180406a11 · Cited by 57
Odamaki, T., Xiao, J.-Z., Iwabuchi, N., Sakamoto, M., Takahashi, N., Kondo, S., Miyaji, K., Iwatsuki, K., Togashi, H., Enomoto, T., et al. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47306-0 · Cited by 53
Self-citationSongjinda, P., Nakayama, J., Tateyama, A., TANAKA, S., TSUBOUCHI, M., Kiyohara, C., Shirakawa, T., & Sonomoto, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70154 · Cited by 50
Self-citation
Cited by
Sorted by citations
The gut microbiome as a major regulator of the gut-skin axis
Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01459 · Cited by 707
Tan, J., McKenzie, C. I., Vuillermin, P., Goverse, G., Vinuesa, C. G., Mebius, R. E., Macia, L., & Mackay, C. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.047 · Cited by 681
Fate, activity, and impact of ingested bacteria within the human gut microbiota
Derrien, M., & van Hylckama Vlieg, J. E. T. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.002 · Cited by 605
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruiz, L., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0010-2016 · Cited by 490
Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 513
Metadata
- Authors
- Enomoto, T., Sowa, M., Nishimori, K., Shimazu, S., Yoshida, A., Yamada, K., Furukawa, F., Nakagawa, T., Yanagisawa, N., Iwabuchi, N., Odamaki, T., Abe, F., Nakayama, J., & Xiao, J.-Z.
- Affiliations
- Hidaka Hospital (JP)
- Japanese Red Cross Society Wakayama Medical Center (JP)
- Wakayama Medical University (JP)
- Morinaga Milk Industry Co., Ltd. (Japan) (JP)
- Kyushu University (JP)
- Corresponding author
- Enomoto, Tadao
- ORCID
- Venue
- Allergology International
- Publisher
- Japanese Society of Allergology
- Published
- 2014
- Volume
- 63
- Issue
- 4
- Pages
- 575-585
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2000251859
- Cited by
- 165
- References
- 43
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 13 · 2023: 10 · 2022: 20 · 2021: 22 · 2020: 12 · 2019: 17 · 2018: 13 · 2017: 12 · 2016: 14 · 2015: 14 · 2014: 2
- FWCI
- 20.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Allergology International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Morinaga Milk Industry
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium, probiotics, Bifidobacterium breve M-16V, Bifidobacterium longum BB536, infant allergy prevention, atopic dermatitis, fecal microbiota, Proteobacteria, maternal gut microbiota, Japanese infants
- MeSH terms
- Adult, Bifidobacterium, Feces, Female, Humans, Hypersensitivity, Infant, Male, Patient Compliance, Pregnancy, Prevalence, Odds Ratio, Probiotics, Biodiversity, Young Adult, Metagenomics, High-Throughput Nucleotide Sequencing, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
