Comparison of mucosal adhesion and species identification of bifidobacteria isolated from healthy and allergic infants
Open accessAbstract
Fifty bifidobacteria strains were isolated from fecal samples of allergic and age matched healthy infants. Allergic infants were found to have an adult type Bifidobacterium flora with high levels of Bifidobacterium adolescentis. Healthy infants had a typical infant Bifidobacterium flora with high levels of Bifidobacterium bifidum. These isolates were tested for their adhesive properties to human intestinal mucus. The adhesion of the fecal bifidobacteria from healthy infants was significantly higher (P<0.0001) than for allergic infants. This suggests a correlation between allergic disease and the composition of the intestinal bifidobacteria flora which has reduced adhesive abilities to the intestinal mucus. Therefore, dietary supplementation of bifidobacteria typical for healthy infants, may be beneficial in the treatment of allergic disorders.
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Aberrancies in specific bifidobacterial microbiota, such as decreased numbers, or atypical species composition, have been identified in atopic disease, IBS, IBD, CRC, or celiac disease.
“Given the attention traditionally paid to the genus Bifidobacterium, aberrancies in specific bifidobacterial microbiota, such as decreased numbers, or atypical species composition, have been identified in some of them (Figure 2); these include atopic disease [94,95] , IBS [96,97] , IBD [98][99][100][101] , CRC [102] , or celiac disease [103,104] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [94]
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Functional food science and gastrointestinal physiology and function
Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398 · see citing works
Self-citationThe intestinal microflora in allergic Estonian and Swedish 2‐year‐old children
Björkstén, Naaber, P., Sepp, & Mikelsaar (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00560.x · Cited by 927 · see citing works
Grölund, M., Lehtonen, O. ‐., Eerola, E., & Kero, P. O. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199901000-00007 · Cited by 873 · see citing works
The Bifidogenic Nature of Chicory Inulin and Its Hydrolysis Products
Roberfroid, M. B., Loo, J. V., & Gibson, G. R. (1998) · Journal of Nutrition · doi:10.1093/jn/128.1.11 · Cited by 781 · see citing works
Benno, Y., Sawada, K., & MITSUOKA, T. (1984) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1984.tb00754.x · Cited by 432 · see citing works
Self-citationBifidobacteria and their role in human health
MITSUOKA, T. (1990) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01575871 · Cited by 385 · see citing works
Schiffrin, E., Brassart, D., Servin, A., Rochat, F., & Donnet-Hughes, A. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.515s · Cited by 354 · see citing works
Selection of strains for probiotic use
Havenaar, R., ten Brink, B., & Veld, J. H. J. H. I. ‘. (1992) · Springer eBooks · doi:10.1007/978-94-011-2364-8_9 · Cited by 341 · see citing works
The ability of probiotic bacteria to bind to human intestinal mucus
Kirjavainen, P. V., Ouwehand, A. C., Isolauri, E., & Salminen, S. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb13226.x · Cited by 280 · see citing works
Self-citationSecular change in the occurrence of atopic dermatitis.
Larsen, F. S., & Hanifin, J. M. (1992) · PubMed · Cited by 226 · see citing works
MITSUOKA, T., & Kaneuchi, C. (1977) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/30.11.1799 · Cited by 220 · see citing works
Comparison of fecal microflora of elderly persons in rural and urban areas of Japan
Benno, Y., Endo, K., Mizutani, T., Namba, Y., Komori, T., & MITSUOKA, T. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.5.1100-1105.1989 · Cited by 195 · see citing works
Self-citationTaxonomy and Ecology of Bifidobacteria
MITSUOKA, T. (1984) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.3.1_11 · Cited by 171 · see citing works
Mucin degradation in human colon ecosystems
Miller, R. S., & Hoskins, L. C. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90503-5 · Cited by 166 · see citing works
Atopic Dermatitis in Infants and Children
Hanifin, J. M. (1991) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)38153-6 · Cited by 152 · see citing works
Healthy gut microflora and allergy: factors influencing development of the microbiota
Kirjavainen, P. V., & Gibson, G. R. (1999) · Annals of Medicine · doi:10.3109/07853899908995892 · Cited by 138 · see citing works
Ouwehand, A. C., Isolauri, E., Kirjavainen, P. V., & Salminen, S. (1999) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1999.tb13450.x · Cited by 134 · see citing works
Self-citationSalminen, S., Laine, M. M., VONWRIGHT, A., Vuopio‐Varkila, J., Korhonen, T., & Mattila, T. (1996) · Bioscience and Microflora · doi:10.12938/bifidus1996.15.61 · Cited by 95 · see citing works
Self-citationBifidobacteria and probiotic action
Ballongue, J. (1993) · Cited by 88 · see citing works
Comparison of the Fecal Microflora in Rural Japanese and Urban Canadians
Benno, Y., Suzuki, K., Suzuki, K., Narisawa, K., Bruce, W. R., & MITSUOKA, T. (1986) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1986.tb02978.x · Cited by 86 · see citing works
Self-citationDoelle, H. W. (1969) · Elsevier eBooks · doi:10.1016/b978-1-4832-3135-8.50011-4 · Cited by 65 · see citing works
The Gut Microflora of the Developing Infant: Microbiology and Metabolism
Heavey, P., & Rowland, I. R. (1999) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v11i2.7887 · Cited by 64 · see citing works
In Vitro Adhesion and Platelet Aggregation Properties of Bacteremia-Associated Lactobacilli
Kirjavainen, P. V., Tuomola, E., Crittenden, R. G., Ouwehand, A. C., Harty, D. W. S., Morris, L. F., Rautelin, H. I. K., PLAYNE, M. J., Donohue, D., & Salminen, S. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2653-2655.1999 · Cited by 62 · see citing works
Self-citationAllergy in early and late onset of atopic dermatitis
Kjellman, B., & Hattevig, G. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13057.x · Cited by 43 · see citing works
Microecology of the gastrointestinal tract and the immunological status under food allergy
Kuvaeva, I. B., Orlova, N. G., Veselova, O. L., et al. (1984) · Food / Nahrung · doi:10.1002/food.19840280645 · Cited by 20 · see citing works
Fecal flora of infants with biliary atresia: effects of the absence of bile on fecal flora
Kobayashi, A., Kawai, S., Ohbe, Y., et al. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.5.1211 · Cited by 15 · see citing works
Shaternikov, V. A., Id, K., Ks, L., et al. (1983) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Ballongue, J. (1998) Bi¢dobacteria and probiotic action. In: Lactic Acid Bacteria. Microbiology and Functional Aspects (Salminen, S. and von Wright, A., Eds.), pp. 519^587. Marcel Dekker, New York.
- Tuomola, E. (1999) In vitro adhesion of probiotic lactic acid bacteria. Doctoral thesis, University of Turku, Finland.
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Development of the gut microbiota in infancy and its impact on health in later life
Tanaka, M., & Nakayama, J. (2017) · Allergology International · doi:10.1016/j.alit.2017.07.010 · Cited by 639 · see citing works
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394 · see citing works
Altered early infant gut microbiota in children developing allergy up to 5 years of age
Sjögren, Y. M., Jenmalm, M. C., Böttcher, M. F., Björkstén, B., & Sverremark‐Ekström, E. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03156.x · Cited by 378 · see citing works
Sjögren, Y. M., Tomicic, S., Lundberg, A., Böttcher, M. F., Björkstén, B., Sverremark‐Ekström, E., & Jenmalm, M. C. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03326.x · Cited by 337 · see citing works
Early life: gut microbiota and immune development in infancy
Martin, R., Nauta, A., Ben Amor, K., Knippels, L., Knol, J., & Garssen, J. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0027 · Cited by 338 · see citing works
Chichlowski, M., De Lartigue, G., German, J. B., Raybould, H. E., & Mills, D. A. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31824fb899 · Cited by 276 · see citing works
Enomoto, T., Sowa, M., Nishimori, K., Shimazu, S., Yoshida, A., Yamada, K., Furukawa, F., Nakagawa, T., Yanagisawa, N., Iwabuchi, N., et al. (2014) · Allergology International · doi:10.2332/allergolint.13-oa-0683 · Cited by 165 · see citing works
Arboleya, S., Ruas-Madiedo, P., Margolles, A., Solís, G., Salminen, S., de los Reyes-Gavilán, C. G., & Gueimonde, M. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.10.036 · Cited by 139 · see citing works
Guglielmetti, S., Tamagnini, I., Mora, D., Minuzzo, M., Scarafoni, A., Arioli, S., Hellman, J., Karp, M., & Parini, C. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00124-08 · Cited by 128 · see citing works
The effect of probiotics on inflammatory biomarkers: A meta-analysis of randomized clinical trials
Milajerdi, A., Mousavi, S. M., Sadeghi, A., Salari-Moghaddam, A., Parohan, M., Larijani, B., & Esmaillzadeh, A. (2020) · European Journal of Nutrition · doi:10.1007/s00394-019-01931-8 · Cited by 123 · see citing works
Li, L., Han, Z., Niu, X., Zhang, G., Jia, Y., Zhang, S., & He, C. (2019) · American Journal of Clinical Dermatology · doi:10.1007/s40257-018-0404-3 · Cited by 122 · see citing works
Odamaki, T., Xiao, J.-Z., Iwabuchi, N., Sakamoto, M., Takahashi, N., Kondo, S., Miyaji, K., Iwatsuki, K., Togashi, H., Enomoto, T., et al. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47306-0 · Cited by 53 · see citing works
Self-citationOrganotypic cultures as aging associated disease models
Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12 · see citing works
- Authors
- He, F., Ouwehand, A. C., Isolauri, E., Hashimoto, H., Benno, Y., & Salminen, S.
- Affiliations
- University of Turku (FI)
- Turku University Hospital (FI)
- Takanashi MILK Products Co., Ltd. (Japan) (JP)
- RIKEN (JP)
- Corresponding author
- Ouwehand, Arthur C.
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02
- Volume
- 30
- Issue
- 1
- Pages
- 43-47
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2165850931
- Cited by
- 220
- References
- 27
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 11 · 2013: 3 · 2012: 11
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland
- Turun Yliopisto
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Bifidobacterium, infant allergy, Bifidobacterium adolescentis, Bifidobacterium bifidum, intestinal bacterial flora, species identification, probiotic supplementation, fecal bacteria
- MeSH terms
- Bacterial Adhesion, Bifidobacterium, Food Hypersensitivity, Humans, Infant, Intestinal Mucosa, Lactobacillus, Mucus, Probiotics
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