The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes
Open accessAbstract
An automated closed-loop insulin delivery system based on subcutaneous glucose sensing and subcutaneous insulin delivery was evaluated in 10 subjects with type 1 diabetes (2 men, 8 women, mean [±SD] age 43.4 ± 11.4 years, duration of diabetes 18.2 ± 13.5 years). Closed-loop control was assessed over ∼30 h and compared with open-loop control assessed over 3 days. Closed-loop insulin delivery was calculated using a model of the β-cell’s multiphasic insulin response to glucose. Plasma glucose was 160 ± 66 mg/dl at the start of closed loop and was thereafter reduced to 71 ± 19 by 1:00 p.m. (preprandial lunch). Fasting glucose the subsequent morning on closed loop was not different from target (124 ± 25 vs. 120 mg/dl, respectively; P > 0.05). Mean glucose levels were not different between the open and closed loop (133 ± 63 vs. 133 ± 52 mg/dl, respectively; P > 0.65). However, glucose was within the range 70–180 mg/dl 75% of the time under closed loop versus 63% for open loop. Incidence of biochemical hypoglycemia (blood glucose <60 mg/dl) was similar under the two treatments. There were no episodes of severe hypoglycemia. The data provide proof of concept that glycemic control can be achieved by a completely automated external closed-loop insulin delivery system.
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Cites
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Cited by
Cryer, P. E., Axelrod, L., Grossman, A. B., Heller, S. R., Montori, V. M., Seaquist, E. R., & Service, F. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1410 · Cited by 1,277
In Silico Preclinical Trials: A Proof of Concept in Closed-Loop Control of Type 1 Diabetes
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“control experiments used a PID controller [259], [260], [290],”
Metadata
- Authors
- Steil, G. M., Rebrin, K., Darwin, C., Hariri, F., & Saad, M. F.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-12-01
- Volume
- 55
- Issue
- 12
- Pages
- 3344-3350
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2127456983
- Cited by
- 473
- References
- 24
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Steil, G. M., Rebrin, K., Darwin, C., Hariri, F., & Saad, M. F. (2006). Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes. Diabetes. https://doi.org/10.2337/db06-0419
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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