Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
Abstract
Background: Sleep exerts important modulatory effects on neuroendocrine function and glucose regulation. During the past few decades, sleep curtailment has become a very common behavior in industrialized countries. This trend toward shorter sleep times has occurred over the same time period as the dramatic increases in the prevalence of obesity and diabetes. Aims: This article will review rapidly accumulating laboratory and epidemiologic evidence indicating that chronic partial sleep loss could play a role in the current epidemics of obesity and diabetes. Conclusions: Laboratory studies in healthy young volunteers have shown that experimental sleep restriction is associated with a dysregulation of the neuroendocrine control of appetite consistent with increased hunger and with alterations in parameters of glucose tolerance suggestive of an increased risk of diabetes. Epidemiologic findings in both children and adults are consistent with the laboratory data.
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Experimental laboratory studies have demonstrated that decreasing either the amount or quality of sleep decreases insulin sensitivity and decreases glucose tolerance.
“Experimental laboratory studies have demonstrated that decreasing either the amount or quality of sleep decreases insulin sensitivity and decreases glucose tolerance.”
From Metabolic effects of sleep disruption, links to obesity and diabetes (2014) · cites this paper as [25]
Short-term decreases in sleep quantity or quality have deleterious effects on glucose regulation.
“Laboratory studies have provided convincing evidence that even short-term decreases in sleep quantity or quality can have deleterious effects on glucose regulation”
From Metabolic effects of sleep disruption, links to obesity and diabetes (2014) · cites this paper as [25]
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- Authors
- van Cauter, E., Holmbäck, U., Knutson, K., Leproult, R., Miller, A., Nedeltcheva, A., Pannain, S., Penev, P., Tasali, E., & Spiegel, K.
- Affiliations
- University of Chicago (US)
- Université Libre de Bruxelles (BE)
- ORCID
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 67
- Issue
- Suppl. 1
- Pages
- 2-9
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W2132764936
- Cited by
- 353
- References
- 11
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 7 · 2023: 15 · 2022: 16 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 20 · 2017: 13 · 2016: 9 · 2015: 19 · 2014: 26 · 2013: 24 · 2012: 22
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research in Paediatrics (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institute on Aging (P01-AG11412., P01AG011412)
- National Heart, Lung, and Blood Institute (R01 HL-75025, R01-HL72694, R01HL072694, R01HL075025)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 20595)
- National Center for Research Resources (P41RR013642, M01RR000055, MO1 RR-00055)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep restriction, neuroendocrine regulation, appetite regulation, hunger, glucose tolerance, obesity, diabetes mellitus, sleep duration, metabolic function
- MeSH terms
- Diabetes Mellitus, Humans, Neurosecretory Systems, Obesity, Risk Factors, Sleep, Sleep Deprivation
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