Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

Postic, C., Shiota, M., Niswender, K. D., Jetton, T. L., Chen, Y., Moates, J. M., Shelton, K. D., Lindner, J., Cherrington, A. D., & Magnuson, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.305 · Cited by 1,302

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

Lin, Z., Tian, H., Lam, K. S. L., Lin, S., Hoo, R. C. L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S. R., Xu, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.005 · Cited by 691

Transcriptional Control of Adipose Lipid Handling by IRF4

Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 597

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537

Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice

Hansen, A. M. K., Vienberg, S. G., Lykkegaard, K., Zhao, X., Tingqing, G., Han, D., Zhang, X., Thøgersen, H., Sass‐Ørum, K., Tagmose, T. M., et al. (2018) · Biochemical Journal · doi:10.1042/bcj20180555 · Cited by 23

Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo

Markan, K. R., Boland, L. K., King-McAlpin, A. Q., Claflin, K. E., Leaman, M. P., Kemerling, M. K., Stonewall, M. M., Amendt, B. A., Ankrum, J. A., & Potthoff, M. J. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.02.008 · Cited by 22

The autocrine role of FGF21 in cultured adipocytes

Justesen, S., Haugegaard, K. V., Hansen, J. B., Hansen, H. S., & Andersen, B. (2020) · Biochemical Journal · doi:10.1042/bcj20200220 · Cited by 25

Leukocyte cell‐derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT‐1 pathway in mice

Wang, J., Chen, Y., Pan, R., Wu, C., Chen, S., Li, L., Li, Y., Yu, C., Meng, Z., & Xu, C. (2021) · Liver International · doi:10.1111/liv.14816 · Cited by 23

An Ultradian Feeding Schedule in Rats Affects Metabolic Gene Expression in Liver, Brown Adipose Tissue and Skeletal Muscle with Only Mild Effects on Circadian Clocks

de Goede, P., Sen, S., Su, Y., Foppen, E., Poirel, V., Challet, É., & Kalsbeek, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103171 · Cited by 22

Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance

Yang, B. C., Wu, S. Y., & Leung, P. S. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.129 · Cited by 22

Role of GPRC6A in Regulating Hepatic Energy Metabolism

Pi, M., Xu, F., Ye, R.-S., Nishimoto, S. K., Williams, R. W., Williams, R. W., Lu, L., & Quarles, L. D. (2019) · Scientific Reports · doi:10.1038/s41598-020-64384-8 · Cited by 22

Fibroblast growth factor 21: A “rheostat” for metabolic regulation?

She, Q.-Y., Bao, J., Wang, H.-Z., Liang, H., Huang, W., Wu, J., Zhong, Y.-W., Ling, H., Li, A., & Qin, S.-L. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155166 · Cited by 22

The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone

Zi, C., Wang, D., Gao, Y., & He, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1104943 · Cited by 23

Hepatic-specific PPARα-FGF21 action in NAFLD

Piccinin, E., & Moschetta, A. (2016) · Gut · doi:10.1136/gutjnl-2016-311408 · Cited by 22

The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk

Valdecantos, M. P., Ruiz, L., Folgueira, C., Rada, P., Gómez‐Santos, B., Solas, M., Hitos, A. B., Field, J., Francisco, V., Escalona-Garrido, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54080-w · Cited by 24

FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions

Maruyama, R., Shimizu, M., Hashidume, T., Inoue, J., Itoh, N., & Sato, R. (2018) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.64.200 · Cited by 21

Reduced insulin signaling in neurons induces sex-specific health benefits

Baghdadi, M., Nespital, T., Mesaros, A., Buschbaum, S., Withers, D. J., Grönke, S., & Partridge, L. (2023) · Science Advances · doi:10.1126/sciadv.ade8137 · Cited by 24

Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77

Zhou, F., Bai, M., Zhang, Y., Zhu, Q., Zhang, L., Zhang, Q., Wang, S., Zhu, K., Liu, Y., Wang, X., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.070 · Cited by 22

Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster

Lewis, J. E., Monnier, C., Marshall, H. J., Fowler, M. J., Green, R., Cooper, S., Chiotellis, A., Luckett, J., Perkins, A. C., Coşkun, T., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.10.009 · Cited by 25

Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus

Guo, C. Y., Zhao, L., Li, Y., Deng, X., & Yuan, G. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29879 · Cited by 21

Fibroblast growth factor receptor signaling in metabolic dysfunction-associated fatty liver disease: Pathogenesis and therapeutic targets

Chu, Y., Yang, S., & Chen, X. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108844 · Cited by 21

Advances in Adipose Tissue Biology

Corvera, S., Rajan, A., Townsend, K. L., Shamsi, F., Wu, J., Svensson, K. J., Zeltser, L. M., Collins, S., Reis, T., Tseng, Y., et al. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf032 · Cited by 27

Hypoxia-Induced Adipose Lipolysis Requires Fibroblast Growth Factor 21

Wu, G., Liu, Y., Feng, W., An, X., Lin, W., & Tang, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01279 · Cited by 20

Comparison of Beneficial Metabolic Effects of Liraglutide and Semaglutide in Male C57BL/6J Mice

Liu, D., Gu, J., Shao, W., Pang, J., Qian, X., & Jin, T. (2021) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2021.08.012 · Cited by 21

Tetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis

Gao, F., Chen, M., Yu, J., Xu, L., Yu, L., Jiang, H., & Gu, Z. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104957 · Cited by 21

Fibroblast Growth Factor 19 and Fibroblast Growth Factor 21 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Gastric Bypass

Guo, J., Chen, H.-H., Lee, W., Chen, S., Lee, S., & Chen, C. (2022) · Nutrients · doi:10.3390/nu14030645 · Cited by 21

The role of innate immunity in the regulation of brown and beige adipogenesis

Alexaki, V. I., & Chavakis, T. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9342-7 · Cited by 21

TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP–ATF response elements in the Fgf21 promoter

Örd, T., Örd, D., & Örd, T. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.01.014 · Cited by 20

Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21–Dependent Mechanism

Ippagunta, S. M., Kharitonenkov, A., Adams, A. C., & Hillgartner, F. B. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy022 · Cited by 21

Biology and pathological implications of brown adipose tissue: promises and caveats for the control of obesity and its associated complications

Tapía, P., Fernández‐Galilea, M., Robledo, F., Mardones, P., Galgani, J. E., & Cortés, V. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12389 · Cited by 21

Carbohydrate Availability as a Regulator of Energy Balance With Exercise

Gonzalez, J. T., Betts, J. A., & Thompson, D. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000196 · Cited by 20

Current understanding and controversies on the clinical implications of fibroblast growth factor 21

Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

Tiwari, V., Jin, B., Sun, O., Gonzalez, E. D. J. L., Chen, M.-H., Wu, X., Shah, H., Zhang, A., Herman, M. A., Spracklen, C. N., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01399-3 · Cited by 20

The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes

Higgins, C. B., Adams, J. A., Ward, M. H., Greenberg, Z. J., Milewska, M., Sun, J., Zhang, Y., Paracatu, L. C., Dong, Q., Ballentine, S. J., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102835 · Cited by 19

The SLC25A47 locus controls gluconeogenesis and energy expenditure

Yook, J.-S., Taxin, Z. H., Yuan, B., Oikawa, S., Auger, C., Mutlu, B., Puigserver, P., Hui, S. T., & Kajimura, S. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216810120 · Cited by 20

Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21

Sui, Y., Liu, Q., Xu, C., Ganesan, K., Ye, Z., Li, Y., Wu, J., Du, B., Gao, F., Song, C., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06386-8 · Cited by 19

Impact of FGF21 on glycemic control

Strowski, M. Z. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0001 · Cited by 20

Transcriptional control and hormonal response of thermogenic fat

Emont, M. P., Yu, H. M., & Wu, J. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0026 · Cited by 19

Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction

Vispute, S. G., Bu, P., Le, Y., & Cheng, X. (2017) · Toxicology · doi:10.1016/j.tox.2017.01.009 · Cited by 19

Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice

Brooks, N. E., Hjortebjerg, R., Henry, B. E., List, E. O., Kopchick, J. J., & Berryman, D. E. (2016) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2016.08.003 · Cited by 18

Mechanisms underlying the metabolic beneficial effect of curcumin intervention: Beyond anti-inflammation and anti-oxidative stress

Jin, T. (2018) · Obesity Medicine · doi:10.1016/j.obmed.2018.11.002 · Cited by 19

FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition

Reilly, S. M., Abu-Odeh, M., Ameka, M., DeLuca, J. H., Naber, M. C., Dadpey, B., Ebadat, N., Gomez, A. V., Peng, X., Poirier, B., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145546 · Cited by 18

Effects and possible mechanisms of intermittent fasting on health and disease: a narrative review

Li, Z., Huang, L., Luo, Y., Yu, B., & Tian, G. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad026 · Cited by 21

Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV

Ramirez, C. E., Agarwal, N., Cox, A. R., Hartig, S. M., Lake, J. E., & Balasubramanyam, A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad028 · Cited by 21

Fibroblast growth factor 21 deficiency aggravates obesity-induced hypothalamic inflammation and impairs thermogenic response

Mutsnaini, L., Kim, C.-S., Kim, J., Joe, Y., Chung, H., Choi, H., Roh, E., Kim, M., & Yu, R. (2019) · Inflammation Research · doi:10.1007/s00011-019-01222-2 · Cited by 18

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Pol, C. J., Pollak, N. M., Jurczak, M. J., Zacharia, E. M., Karagiannides, I., Kyriazis, I. D., Ntziachristos, P., Scerbo, D. A., Brown, B. R., Aifantis, I., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.010 · Cited by 18

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis

Gourronc, F. A., Markan, K. R., Kulhánková, K., Zhu, Z., Sheehy, R. M., Quelle, D. E., Zingman, L. V., Kurago, Z., Ankrum, J. A., & Klingelhutz, A. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236741 · Cited by 19

Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism

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Dual effects of fibroblast growth factor 21 on hepatic energy metabolism

Samms, R. J., Murphy, M., Fowler, M. J., Cooper, S., Emmerson, P. J., Coşkun, T., Adams, A. C., Kharitonenkov, A., Ebling, F. J. P., & Tsintzas, K. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0334 · Cited by 17

Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension

Papathanasiou, A. E., Spyropoulos, F., Michael, Z., Joung, K. E., Briana, D. D., Malamitsi‐Puchner, A., Mantzoros, C. S., & Christou, H. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031435 · Cited by 17

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Mizumoto, T., Yoshizawa, T., Sato, Y., Ito, T., Tsuyama, T., Satoh, A., Araki, S., Tsujita, K., Tamura, M., Oike, Y., et al. (2022) · Cells · doi:10.3390/cells11223609 · Cited by 18

Fibroblast Growth Factor 21-Null Mice Do Not Exhibit an Impaired Response to Fasting

Antonellis, P. J., Hayes, M. P., & Adams, A. C. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00077 · Cited by 17

Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator‐activated receptor γ coactivator‐1α‐deficient mice

Fletcher, J. A., Linden, M. A., Sheldon, R. D., Meers, G. M.-E., Morris, E. M., Butterfield, A. M., Perfield, J. W., Rector, R. S., & Thyfault, J. P. (2017) · Experimental Physiology · doi:10.1113/ep086629 · Cited by 17

What Can ‘Brown-ing’ Do For You?

Singh, A. M., & Dalton, S. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.03.002 · Cited by 18

Protein Status Modulates an Appetite for Protein To Maintain a Balanced Nutritional State—A Perspective View

Tomé, D., Chaumontet, C., Even, P. C., Darcel, N., Thornton, S. N., & Azzout‐Marniche, D. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05990 · Cited by 19

Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation

Dey, S., Cui, Z., Gavrilova, O., Zhang, X., Gassmann, M., & Noguchi, C. T. (2020) · JCI Insight · doi:10.1172/jci.insight.134061 · Cited by 17

Glucagon-dependent suppression of mTORC1 is associated with upregulation of hepatic FGF21 mRNA translation

Welles, J. E., Dennis, M. D., Jefferson, L. S., & Kimball, S. R. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00555.2019 · Cited by 17

A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms

Kawanishi, H., Ohashi, K., Ogawa, H., Otaka, N., Takikawa, T., Fang, L., Ozaki, Y., Takefuji, M., Murohara, T., & Ouchi, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235362 · Cited by 17

Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance

Eder, K., Geßner, D. K., & Ringseis, R. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00621-y · Cited by 18

Gene expression in WAT from healthy humans and monkeys correlates with FGF 21‐induced browning of WAT in mice

Schlessinger, K., Li, W., Tan, Y., Liu, F., Souza, S. C., Tozzo, E., Liu, K., Thompson, J. R., Wang, L., & Muise, E. S. (2015) · Obesity · doi:10.1002/oby.21153 · Cited by 17

Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21

Zarei, M., Pujol, E., Quesada‐López, T., Villarroya, F., Barroso, E., Vázquez, S., Pizarro‐Delgado, J., Palomer, X., & Vázquez‐Carrera, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14678 · Cited by 17

Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats

Alizadeh‐Fanalou, S., Babaei, M., Hosseini, A., Azadi, N. A., Nazarizadeh, A., Shojaii, A., Borji, M., Malekinejad, H., & Bahreini, E. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112331 · Cited by 17

Activated brown adipose tissue and its relationship to adiposity and metabolic markers: an exploratory study

Soundarrajan, M., Deng, J., Kwasny, M., Rubert, N. C., Nelson, P. C., Abou-el-Seoud, D., Landsberg, L., & Neff, L. M. (2020) · Adipocyte · doi:10.1080/21623945.2020.1724740 · Cited by 20

Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet

Nonogaki, K., & Kaji, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-72975-8 · Cited by 16

Protein-Restricted Diets and Their Impact on Metabolic Health and Aging

Kim, S. Q., Spann, R. A., Hill, C. M., Berryman, C. E., Berthoud, H., McDougal, D. H., He, Y., Münzberg, H., Yu, S., & Morrison, C. D. (2025) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121624-114918 · Cited by 17

Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet

Men, L., Hui, W., Guan, X., Song, T., Wang, X., Zhang, S., & Chen, X. (2020) · Genes · doi:10.3390/genes11070720 · Cited by 16

A human laboratory study on the link between alcohol administration and circulating fibroblast growth factor 21 (FGF21) in individuals with alcohol use disorder

Farokhnia, M., Wang, T., Jourdan, T., Godlewski, G., Farinelli, L. A., Kunos, G., & Leggio, L. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.109809 · Cited by 16

Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice

Mayer, A. L., Zhang, Y., Feng, E. H., Higgins, C. B., Adenekan, O., Pietka, T., Beatty, W. L., & DeBosch, B. J. (2018) · Endocrinology · doi:10.1210/en.2017-03150 · Cited by 16

Microbiota-Liver-Bile Salts Axis, a Novel Mechanism Involved in the Contrasting Effects of Sodium Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Development in Adolescent Rats

Ojeda, M. L., Nogales, F., Carrasco, J. A., Gallego‐López, M. D. C., Carreras, O., Alcudia, A., & Pajuelo, E. (2023) · Antioxidants · doi:10.3390/antiox12051123 · Cited by 17

Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms

Richter, M. M., Kemp, I. M., Heebøll, S., Winther‐Sørensen, M., Kjeldsen, S. A. S., Jensen, N. J., Nybing, J. D., Linden, F. H., Høgh‐Schmidt, E., Boesen, M., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155915 · Cited by 15

Fibroblast growth factor 21

Trusz, G. J. (2024) · Differentiation · doi:10.1016/j.diff.2024.100793 · Cited by 15

In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice

Paré, F., Tardif, G., Fahmi, H., Ouhaddi, Y., Pelletier, J., & Martel‐Pelletier, J. (2020) · Aging · doi:10.18632/aging.102784 · Cited by 16

Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury

Christidis, G., Karataylı, E., Hall, R. A., Weber, S. N., Reichert, M., Hohl, M., Qiao, S., Boehm, U., Lütjohann, D., Lammert, F., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157898 · Cited by 15

Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study

Buell‐Acosta, J. D., Garcés, M. F., Baños, A. J. P., Ángel‐Müller, E., Páez, M. C., Eslava-Schmalbach, J. H., Escobar-Córdoba, F., Caminos-Cepeda, S. A., Lacunza, E., Castano, J. P., et al. (2022) · Cells · doi:10.3390/cells11142251 · Cited by 15

FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP

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Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System

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Exploring endocrine FGFs - structures, functions and biomedical applications

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Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet

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FGF21 mediating the Sex-dependent Response to Dietary Macronutrients

Sauza, K. A. S., & Ryan, K. K. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae363 · Cited by 14

Hepatic function of glucagon-like peptide-1 and its based diabetes drugs

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Ketogenic diet with aerobic exercise can induce fat browning: potential roles of β-hydroxybutyrate

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FAP finds FGF21 easy to digest

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The Level of FGF 21 as a New Risk Factor for the Occurrence of Cardiometabolic Disorders amongst the Psoriatic Patients

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Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart

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Liver‐derived FGF21 is required for the effect of time‐restricted feeding on high‐fat diet‐induced fatty liver in mice

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What does self‐selection of dietary proteins in rats tell us about protein requirements and body weight control?

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Tryptophan Hydroxylase 1 Regulates Tryptophan and Its Metabolites

Nonogaki, K., & Kaji, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093978 · Cited by 14

FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue

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ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms

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Head Over Hepatocytes for FGF21

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Attenuation of FGF21 signalling might aggravate the impairment of glucose homeostasis during the high sucrose diet induced transition from prediabetes to diabetes in WNIN/GR-Ob rats

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The regulation and role of carbohydrate response element‐binding protein in metabolic homeostasis and disease

Jois, T., & Sleeman, M. W. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12473 · Cited by 14

Association between Serum Fibroblast Growth Factor 21 Levels and Bone Mineral Density in Postmenopausal Women

Choi, H. S., Lee, H. A., Kim, S.-W., & Cho, E.-H. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.2.273 · Cited by 13

Short and long-term effects of high-intensity interval training applied alone or with whole-body cryostimulation on glucose homeostasis and myokine levels in overweight to obese subjects

Flis, M., Rodziewicz-Flis, E. A., Micielska, K., Kortas, J. A., Jaworska, J., Borkowska, A., Sansoni, V., Perego, S., Lombardi, G., & Ziemann, E. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5015 · Cited by 16

Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice

Liu, X., Graham, Z., Harlow, L., Pan, J., Azulai, D., Bauman, W. A., Yarrow, J. F., & Cardozo, C. P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668984 · Cited by 12

Fibroblast growth factor 21 and prognosis of patients with cardiovascular disease: A meta-analysis

Yan, B., Ma, S., Yan, C., & Han, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1108234 · Cited by 12

Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation

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Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes

Richter, M. M., Thomsen, M. N., Skytte, M. J., Kjeldsen, S. A. S., Samkani, A., Frystyk, J., Magkos, F., Holst, J. J., Madsbad, S., Krarup, T., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae008 · Cited by 13

Characterization of FGF21 Sites of Production and Signaling in Mice

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Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock

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Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression

Chen, S., Li, H., Zhang, J., Jiang, S., Zhang, M., Xu, Y., Dong, K., Yang, Y., Fang, Q., & Jia, W. (2017) · BioMed Research International · doi:10.1155/2017/8402035 · Cited by 12

Circulating Fibroblast Growth Factor-21 and Risk of Metachronous Colorectal Adenoma

Florea, A., Harris, R. B., Klimentidis, Y. C., Kohler, L. N., Jurutka, P. W., & Jacobs, E. T. (2020) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-020-00515-8 · Cited by 11

Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers

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Molecular methods to study protein trafficking between organs

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Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

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Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

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Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls

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insulin-sensitizing action of FGF21 in insulin-resistant mouse

(2009)

Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

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