Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

FGF-21 as a novel metabolic regulator

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Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

Postic, C., Shiota, M., Niswender, K. D., Jetton, T. L., Chen, Y., Moates, J. M., Shelton, K. D., Lindner, J., Cherrington, A. D., & Magnuson, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.305 · Cited by 1,302

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

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Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

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Transcriptional Control of Adipose Lipid Handling by IRF4

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Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537

Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis

Watanabe, M., Singhal, G., Fisher, F. M., Beck, T. C., Morgan, D. A., Socciarelli, F., Mather, M. L., Risi, R., Bourke, J., Rahmouni, K., et al. (2019) · Endocrine · doi:10.1007/s12020-019-02124-3 · Cited by 44

Time‐restricted feeding improves the reproductive function of female mice via liver fibroblast growth factor 21

Hua, L., Feng, B., Huang, L., Li, J., Luo, T. F., Jiang, X., Han, X., Che, L., Xu, S., Lin, Y., et al. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.195 · Cited by 43

Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy

Gao, J., Liu, J., Meng, Z., Li, Y., Hong, Y., Wang, L., He, L., Hu, B. Q., Zheng, Y., Li, T., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.015 · Cited by 44

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

Han, M. S., Perry, R. J., Camporez, J.-P., Scherer, P. E., Shulman, G. I., Gao, G., & Davis, R. J. (2021) · Genes & Development · doi:10.1101/gad.344556.120 · Cited by 43

Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice

Chaumontet, C., Azzout-Marniche, D., Blais, A., Piedcoq, J., Tomé, D., Gaudichon, C., & Even, P. C. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2018 · Cited by 42

Fibroblast Growth Factor-21 as a Potential Therapeutic Target of Nonalcoholic Fatty Liver Disease

Raptis, D. D., Mantzoros, C., & Polyzos, S. (2023) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s352008 · Cited by 31

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification

Fritsche, K., Ziková, A., Marx‐Stoelting, P., & Braeuning, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032686 · Cited by 42

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

Zarei, M., Barroso, E., Leiva, R., Barniol‐Xicota, M., Pujol, E., Escolano, C., Vázquez, S., Palomer, X., Pardo, V., González‐Rodríguez, Á., et al. (2016) · Diabetes · doi:10.2337/db16-0155 · Cited by 42

Suppression of Resting Metabolism by the Angiotensin AT2 Receptor

Littlejohn, N. K., Keen, H. L., Weidemann, B. J., Claflin, K. E., Tobin, K. V., Markan, K. R., Park, S., Naber, M. C., Gourronc, F. A., Pearson, N. A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.003 · Cited by 41

The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury

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Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting

Zhang, Y., Higgins, C. B., Fortune, H. M., Chen, P., Stothard, A. I., Mayer, A. L., Swarts, B. M., & DeBosch, B. J. (2019) · Nature Communications · doi:10.1038/s41467-019-09642-8 · Cited by 40

Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice

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Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies

Hua, S., Liu, Q., Li, J., Fan, M., Yan, K., & Ye, D. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09661-1 · Cited by 39

Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

Patel, S., Haider, A., Álvarez-Guaita, A., Bidault, G., Moustafa, J. S. E.-S., Guiu‐Jurado, E., Tadross, J. A., Warner, J., Harrison, J., Virtue, S., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101589 · Cited by 42

Beyond the Liver: Liver-Eye Communication in Clinical and Experimental Aspects

Yuan, T.-H., Yue, Z., Zhang, G.-H., Wang, L., & Dou, G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.823277 · Cited by 39

Liver Brain Interactions: Focus on FGF21 a Systematic Review

Prida, E., Álvarez-Delgado, S., Pérez-Lois, R., Soto-Tielas, M., Estany‐Gestal, A., Fernø, J., Seoane, L. M., Quiñones, M., & Al–Massadi, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113318 · Cited by 40

A BAT-Centric Approach to the Treatment of Diabetes: Turn on the Brain

Hankir, M. K., Cowley, M. A., & Fenske, W. K. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.003 · Cited by 39

Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency

Yan, Z., Kronemberger, A., Blomme, J., Call, J. A., Caster, H. M., Pereira, R. O., Zhao, H., Melo, V. U. D., Laker, R. C., Zhang, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08480-2 · Cited by 38

Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature

Libby, A. E., Bales, E. S., Monks, J., Orlicky, D. J., & McManaman, J. L. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m086249 · Cited by 38

Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes

Chalvon-Demersay, T., Even, P. C., Tomé, D., Chaumontet, C., Piedcoq, J., Gaudichon, C., & Azzout-Marniche, D. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.07.002 · Cited by 37

Protein metabolism and related body function: mechanistic approaches and health consequences

Tomé, D., Benoit, S., & Azzout‐Marniche, D. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120007880 · Cited by 39

The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes

Izaguirre, M., Gil, M. J., Monreal, I., Montecucco, F., Frühbeck, G., & Catalán, V. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0866-3 · Cited by 41

Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress–Fibroblast Growth Factor 21 Axis in Skeletal Muscle

Montgomery, M. K., Mokhtar, R. A. M., Bayliss, J. A., Parkington, H. C., Suturin, V. M., Bruce, C. R., & Watt, M. J. (2018) · Diabetes · doi:10.2337/db17-0923 · Cited by 37

Cyanidin-3-O-β-glucoside regulates the activation and the secretion of adipokines from brown adipose tissue and alleviates diet induced fatty liver

Pei, L., Wan, T., Wang, S., Ye, M., Qiu, Y., Jiang, R., Pang, N., Huang, Y., Zhou, Y., Jiang, X., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.018 · Cited by 38

Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle

Kim, C.-S., Joe, Y., Choi, H., Back, S. H., Park, J. W., Chung, H., Roh, E., Kim, M., Ha, T. Y., & Yu, R. (2019) · Journal of Inflammation · doi:10.1186/s12950-019-0221-3 · Cited by 36

Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

Li, S., Zou, T., Chen, J., Li, J., & You, J. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.033 · Cited by 37

Therapeutic Approaches to Alzheimer’s Type of Dementia: A Focus on FGF21 Mediated Neuroprotection

Taliyan, R., Chandran, S. K., & Kakoty, V. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190716101411 · Cited by 35

Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis

Shenoy, V. K., Beaver, K. M., Fisher, F. M., Singhal, G., Dushay, J. R., Maratos–Flier, E., & Flier, S. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164351 · Cited by 36

FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury

Yang, X., Chen, H. H., Shen, W., Chen, Y., Lin, Z., Zhuo, J., Wang, S., Yang, M., Li, H., He, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52379-2 · Cited by 35

Leptin as a Potential Regulator of FGF21

Asrih, M., Veyrat‐Durebex, C., Poher, A.-L., Lyautey, J., Rohner‐Jeanrenaud, F., & Jornayvaz, F. R. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000443070 · Cited by 35

LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice

Le, C. T., Nguyen, G., Park, S. Y., Choi, D. H., & Cho, E.-H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192146 · Cited by 35

Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ

Higgins, C. B., Zhang, Y., Mayer, A. L., Fujiwara, H., Stothard, A. I., Graham, M. J., Swarts, B. M., & DeBosch, B. J. (2018) · JCI Insight · doi:10.1172/jci.insight.120794 · Cited by 37

Hepatokines as a Molecular Transducer of Exercise

Seo, D. Y., Park, S.-H., Marquez, J. C., Kwak, H., Kim, T. N., Bae, J. H., Koh, J., & Han, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030385 · Cited by 37

Acute hyperenergetic, high-fat feeding increases circulating FGF21, LECT2, and fetuin-A in healthy men

Willis, S. A., Sargeant, J. A., Yates, T., Takamura, T., Takayama, H., Gupta, V., Brittain, E., Crawford, J., Parry, S. A., Thackray, A. E., et al. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxz333 · Cited by 34

A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target‐gene expression

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Glucagon receptor signaling regulates weight loss via central KLB receptor complexes

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Modulation of energy balance by fibroblast growth factor 21

Ramos, D. C., & Aguilar-Salinas, C. A. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0023 · Cited by 36

Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers

Sui, Y., & Chen, J. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.76924 · Cited by 33

Molecular mechanism and therapeutic significance of essential amino acids in metabolically associated fatty liver disease

Deng, Y., Hu, M., Huang, S., & Fu, N. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109581 · Cited by 34

Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target

Milani, I., Codini, M., Guarisco, G., Chinucci, M., Gaita, C., Leonetti, F., & Capoccia, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910795 · Cited by 40

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

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Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone

Phillips, K. J. (2019) · Biology · doi:10.3390/biology8030057 · Cited by 35

Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway

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The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression

En, M., Kazantseva, A. Y., Dubinina, A., Jakovleva, T., Balybina, N., Baranov, K. O., & Бажан, Н. М. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910561 · Cited by 33

Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer

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Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21

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The Potential Role of Exosomes in Child and Adolescent Obesity

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Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation

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Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue

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FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk

CHAFFIN, A. T. B., Larson, K. R., Huang, K.-P., Wu, C.-T., Nadejda, G., Fang, Y., Jayakrishnan, D., Sauza, K. A. S., Sims, L. C., Mohajerani, N., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155848 · Cited by 31

Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4

Alonge, K. M., Meares, G. P., & Hillgartner, F. B. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.762922 · Cited by 32

Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Kobayashi, M., Uta, S., Otsubo, M., Deguchi, Y., Tagawa, R., Mizunoe, Y., Nakagawa, Y., Shimano, H., & Higami, Y. (2020) · Nutrients · doi:10.3390/nu12072054 · Cited by 32

Time‐restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling

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Mechanistic insights into the liver–brain axis during chronic liver disease

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Effect of mitochondrial stress on systemic metabolism

Lee, M. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12822 · Cited by 32

The role of FGF21 in type 1 diabetes and its complications

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Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue

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Maintenance of liver glycogen during long‐term fasting preserves energy state in mice

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Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction

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Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77–FGF21 pathway

Ahuja, P., Bi, X., Ng, C. F., Tse, M. C. L., Hang, M., Pang, B. P. S., Iu, E. C. Y., Chan, W. S., Ooi, X. C., Sun, A., et al. (2022) · Hepatology · doi:10.1002/hep.32501 · Cited by 30

Mechanistic insight into nuclear receptor‐mediated regulation of bile acid metabolism and lipid homeostasis by grape seed procyanidin extract (GSPE)

Downing, L. E., Edgar, D., Ellison, P. A., & Ricketts, M. (2017) · Cell Biochemistry and Function · doi:10.1002/cbf.3247 · Cited by 30

TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose

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Lycopene alleviates age-related cognitive deficit via activating liver-brain fibroblast growth factor-21 signalling

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The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity

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Relationship of fibroblast growth factor 21 levels with inflammation, lipoproteins and non-alcoholic fatty liver disease

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Dietary Intake Regulates White Adipose Tissues Angiogenesis via Liver Fibroblast Growth Factor 21 in Male Mice

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Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice

Chalvon‐Demersay, T., Even, P. C., Chaumontet, C., Piedcoq, J., Viollet, B., Gaudichon, C., Tomé, D., Foretz, M., & Azzout‐Marniche, D. (2017) · Journal of Nutrition · doi:10.3945/jn.117.250803 · Cited by 29

Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations

Fletcher, J. A., Linden, M. A., Sheldon, R. D., Meers, G. M.-E., Morris, E. M., Butterfield, A. M., Perfield, J. W., Thyfault, J. P., & Rector, R. S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00355.2015 · Cited by 28

Gluco-metabolic effects of oral and intravenous alcohol administration in men

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DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism

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Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

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