The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
Open accessAbstract
Recruitment of brown adipose tissue (BAT) has emerged as a potential tool to combat obesity and associated metabolic complications. Short-term cold acclimation has been shown not only to enhance the presence and activity of BAT in lean humans but also to improve the metabolic profile of skeletal muscle to benefit glucose uptake in patients with type 2 diabetes. Here we examined whether short-term cold acclimation also induced such adaptations in 10 metabolically healthy obese male subjects. A 10-day cold acclimation period resulted in increased cold-induced glucose uptake in BAT, as assessed by [18F]fluorodeoxyglucose positron emission tomography/computed tomography. BAT activity was negatively related to age, with a similar trend for body fat percentage. In addition, cold-induced glucose uptake in BAT was positively related to glucose uptake in visceral white adipose tissue, although glucose uptake in visceral and subcutaneous white adipose tissue depots was unchanged upon cold acclimation. Cold-induced skeletal muscle glucose uptake tended to increase upon cold acclimation, which was paralleled by increased basal GLUT4 localization in the sarcolemma, as assessed through muscle biopsies. Proximal skin temperature was increased and subjective responses to cold were slightly improved at the end of the acclimation period. These metabolic adaptations to prolonged exposure to mild cold may lead to improved glucose metabolism or prevent the development of obesity-associated insulin resistance and hyperglycemia.
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Cites
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Self-citationFunctional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608
Phielix, E., Schrauwen-Hinderling, V. B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J., Kooi, M. E., Moonen-Kornips, E., Sels, J.-P., Hesselink, M. K. C., et al. (2008) · Diabetes · doi:10.2337/db08-0391 · Cited by 359
Self-citationHoeks, J., van Herpen, N. A., Mensink, M., Moonen-Kornips, E., van Beurden, D., Hesselink, M. K. C., & Schrauwen, P. (2010) · Diabetes · doi:10.2337/db10-0519 · Cited by 156
Self-citationBrown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
Saito, M. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.22 · Cited by 146
Increased Glucose Uptake in Visceral Versus Subcutaneous Adipose Tissue Revealed by PET Imaging
Christen, T., Sheikine, Y., Rocha, V. Z., Hurwitz, S., Goldfine, A. B., Di Carli, M., & Libby, P. (2010) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2010.06.004 · Cited by 120
Cited by
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Mapping of human brown adipose tissue in lean and obese young men
Leitner, B. P., Huang, S., Brychta, R. J., Duckworth, C. J., Baskin, A. S., McGehee, S., Tal, I., Dieckmann, W., Gupta, G., Kolodny, G. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705287114 · Cited by 530
Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus
Hesselink, M. K. C., Schrauwen-Hinderling, V., & Schrauwen, P. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.104 · Cited by 242
Self-citationDrivers of diversity in human thermal perception – A review for holistic comfort models
Schweiker, M., Huebner, G. M., Kingma, B. R. M., Kramer, R., & Pallubinsky, H. (2018) · Temperature · doi:10.1080/23328940.2018.1534490 · Cited by 231
Obesity: A neuroimmunometabolic perspective
Larabee, C. M., Neely, O. C., & Domingos, A. I. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0283-6 · Cited by 123
Metadata
- Authors
- Hanssen, M. J. W., van der Lans, A. A. J. J., Brans, B., Hoeks, J., Jardon, K. M. C., Schaart, G., Mottaghy, F. M., Schrauwen, P., & van Marken Lichtenbelt, W. D.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2015-12-30
- Volume
- 65
- Issue
- 5
- Pages
- 1179-1189
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2309729441
- Cited by
- 293
- References
- 7
- FWCI
- 15.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hanssen, M. J. W., van der Lans, A. A. J. J., Brans, B., Hoeks, J., Jardon, K. M. C., Schaart, G., Mottaghy, F. M., Schrauwen, P., & van Marken Lichtenbelt, W. D. (2016). Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans. Diabetes. https://doi.org/10.2337/db15-1372
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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