Cited by 147Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans

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Saito, Masayuki·2013·Diabetes & Metabolism Journal

Abstract

Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.

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Authors
Saito, M.
Affiliations
Tenshi College (JP)
Corresponding author
Saito, Masayuki
Venue
Diabetes & Metabolism Journal
Published
2013
Volume
37
Issue
1
Pages
22
ISSN
  • 2233-6079 (ISSN-L)
  • 2233-6087
OpenAlex
W2168695748
Cited by
146
References
55
Citations by year
2026: 4 · 2025: 10 · 2024: 6 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 11 · 2013: 12
FWCI
13.00
Type
journal article
Language
en
Open access
Locations
  • Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science (24240092)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
brown adipose tissue, non-shivering thermogenesis, energy expenditure, fat mass, cold exposure, obesity, capsaicin, capsinoids, TRP channels, aging

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