Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
Open accessAbstract
Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.
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Meal-associated thermogenesis exists.
“It has been demonstrated by several groups that there is a meal‐associated thermogenesis 101, 102, 103.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [103]
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- Authors
- Saito, M.
- Affiliations
- Tenshi College (JP)
- Corresponding author
- Saito, Masayuki
- ORCID
- Saito, Masayuki
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2013
- Volume
- 37
- Issue
- 1
- Pages
- 22
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC3579148
- OpenAlex
- W2168695748
- Cited by
- 146
- References
- 55
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 11 · 2013: 12
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (24240092)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- brown adipose tissue, non-shivering thermogenesis, energy expenditure, fat mass, cold exposure, obesity, capsaicin, capsinoids, TRP channels, aging
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