The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1
Open accessAbstract
Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2 diabetes (T2D) compared with age-matched men, but this advantage disappears after menopause with disrupted glucose homeostasis, in part owing to a reduction in circulating 17β-estradiol (E2). Fasting hyperglycemia is a hallmark of T2D derived largely from dysregulation of hepatic glucose production (HGP), in which Foxo1 plays a central role in the regulation of gluconeogenesis. Here, we investigated the action of E2 on glucose homeostasis in male and ovariectomized (OVX) female control and liver-specific Foxo1 knockout (L-F1KO) mice and sought to understand the mechanism by which E2 regulates gluconeogenesis via an interaction with hepatic Foxo1. In both male and OVX female control mice, subcutaneous E2 implant improved insulin sensitivity and suppressed gluconeogenesis; however, these effects of E2 were abolished in L-F1KO mice of both sexes. In our use of mouse primary hepatocytes, E2 suppressed HGP and gluconeogenesis in hepatocytes from control mice but failed in hepatocytes from L-F1KO mice, suggesting that Foxo1 is required for E2 action on the suppression of gluconeogenesis. We further demonstrated that E2 suppresses hepatic gluconeogenesis through activation of estrogen receptor (ER)α–phosphoinositide 3-kinase–Akt–Foxo1 signaling, which can be independent of insulin receptor substrates 1 and 2 (Irs1 and Irs2), revealing an important mechanism for E2 in the regulation of glucose homeostasis. These results may help explain why premenopausal women have lower incidence of T2D than age-matched men and suggest that targeting ERα can be a potential approach to modulate glucose metabolism and prevent diabetes.
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Citations
Cites
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“Both clinical and animal studies show a strong correlation between estrogen deficiency and metabolic dysfunction (2,3).”
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The diversity of sex steroid action: regulation of metabolism by estrogen signaling
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“6A), and expression of G6pc and Pck1 (Fig.”
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Cited by
Oosthuyse, T., Strauss, J. A., & Hackney, A. C. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05090-3 · Cited by 70
Smati, S., Régnier, M., Fougeray, T., Polizzi, A., Fougerat, A., Lasserre, F., Lukowicz, C., Tramunt, B., Guillaume, M., Burnol, A.-F., et al. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.05.005 · Cited by 47
Factors Influencing Substrate Oxidation During Submaximal Cycling: A Modelling Analysis
Rothschild, J. A., Kilding, A. E., Stewart, T., & Plews, D. J. (2022) · Sports Medicine · doi:10.1007/s40279-022-01727-7 · Cited by 46
An estrogen receptor α-derived peptide improves glucose homeostasis during obesity
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Self-citationLee, A. A., & Den Hartigh, L. J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1682231 · Cited by 32
“Interestingly, recent studies suggest that SHBG may partially TABLE 2 Summary of the impact of perturbing circulating and WAT-derived sex steroids on metabolic disease and aging in mouse models.”
Metadata
- Authors
- Yan, H., Yang, W., Zhou, F., Li, X., Pan, Q., Shen, Z., Han, G., Newell-Fugate, A., Tian, Y., Majeti, R., Liu, W., Xu, Y., Wu, C., Allred, K., Allred, C., Sun, Y., & Guo, S.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2018-11-27
- Volume
- 68
- Issue
- 2
- Pages
- 291-304
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2903378764
- Cited by
- 338
- References
- 14
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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