Predicting 6-Year Mortality Risk in Patients With Type 2 Diabetes
Open accessAbstract
OBJECTIVE—The objective of this study was to create a tool that predicts the risk of mortality in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS—This study was based on a cohort of 33,067 patients with type 2 diabetes identified in the Cleveland Clinic electronic health record (EHR) who were initially prescribed a single oral hypoglycemic agent between 1998 and 2006. Mortality was determined in the EHR and the Social Security Death Index. A Cox proportional hazards regression model was created using medication class and 20 other predictor variables chosen for their association with mortality. A prediction tool was created using the Cox model coefficients. The tool was internally validated using repeated, random subsets of the cohort, which were not used to create the prediction model. RESULTS—Follow-up in the cohort ranged from 1 day to 8.2 years (median 28.6 months), and 3,661 deaths were observed. The prediction tool had a concordance index (i.e., c statistic) of 0.752. CONCLUSIONS—We successfully created a tool that accurately predicts mortality risk in patients with type 2 diabetes. The incorporation of medications into mortality predictions in patients with type 2 diabetes should improve treatment decisions.
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- Authors
- Wells, B. J., Jain, A., Arrigain, S., Yu, C., Rosenkrans, W. A., & Kattan, M. W.
- Affiliations
- Cleveland Clinic (US)
- Massachusetts Institute of Technology (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2008-12-01
- Volume
- 31
- Issue
- 12
- Pages
- 2301-2306
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2584185
- OpenAlex
- W2100982363
- Cited by
- 51
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 4 · 2015: 5 · 2014: 2 · 2013: 7 · 2012: 7
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, mortality prediction, predictive tools, oral antidiabetic drugs, medication classes, Cox proportional hazards model, concordance index, internal validation, electronic health records
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Cohort Studies, Proportional Hazards Models, Risk Assessment
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