Maternally Transmitted and Food-Derived Glycotoxins
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OBJECTIVE: Proinflammatory advanced glycation end products (AGEs) found in thermally processed foods correlate with serum AGEs (sAGEs) and promote type 1 and type 2 diabetes in mice. Herein we assess the relationship of maternal blood and food AGEs to circulating glycoxidants, inflammatory markers, and insulin levels in infants up to age 1 year. RESEARCH DESIGN AND METHODS: AGEs (Nε-carboxymethyllysine [CML] and methylglyoxal derivatives) were tested in sera of healthy mothers in labor (n = 60), their infants, and infant foods. Plasma 8-isoprostane, fasting glucose, insulin, leptin, and adiponectin levels were assessed in 12-month-old infants. RESULTS: Significant correlations were found between newborn and maternal serum CML (sCML) (r = 0.734, P = 0.001) serum methylglyoxal derivatives (sMGs) (r = 0.593, P = 0.001), and 8-isoprostanes (r = 0.644, P = 0.001). Infant adiponectin at 12 months negatively correlated with maternal sCML (r = −0.467, P = 0.011), whereas high maternal sMGs predicted higher infant insulin or homeostasis model assessment (P = 0.027). Infant sAGEs significantly increased with the initiation of processed infant food intake, raising daily AGE consumption by ∼7.5-fold in year 1. CONCLUSIONS: Maternal blood and food-derived AGEs prematurely raise AGEs in children to adult norms, preconditioning them to abnormally high oxidant stress and inflammation and thus possibly to early onset of disease, such as diabetes.
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In both animal models and human studies, exposure to high levels of dietary AGEs during fetal development triggers metabolic reprogramming leading to T2DM independently of genetic predisposition.
“Additionally, in both animal models and human studies exposure to high levels of dietary AGEs during fetal development has been shown to trigger metabolic reprogramming which leads to the development of T2DM independently of any genetic predisposition.[125,126]”
From The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction (2021) · cites this paper as [126]
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- Authors
- Mericq, V., Piccardo, C., Cai, W., Chen, X., Zhu, L., Striker, G. E., Vlassara, H., & Uribarri, J.
- Affiliations
- Institute of Maternal and Child Research, University of Chile, Santiago, Chile;
- University of Chile (CL)
- Icahn School of Medicine at Mount Sinai (US)
- Department of Geriatrics, The Mount Sinai School of Medicine, New York, New York;
- Corresponding author
- Uribarri, Jaime
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2010-07-13
- Volume
- 33
- Issue
- 10
- Pages
- 2232-2237
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2945165
- OpenAlex
- W2124905655
- Cited by
- 82
- References
- 27
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 9 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 10
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- U.S. Public Health Service (AGE-09453)
- National Institute on Aging (AG23188, R37AG023188)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- advanced glycation end products, carboxymethyllysine, methylglyoxal, baby food, processed foods, 8-isoprostane, adiponectin, insulin, leptin, oxidative stress, inflammation, diabetes risk, maternal-fetal transfer
- MeSH terms
- Adolescent, Adult, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Infant, Infant Food, Infant, Newborn, Insulin, Lysine, Pyruvaldehyde, Risk Factors, Glycation End Products, Advanced, Isoprostanes, Adiponectin, Young Adult
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