The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Relationship of Dopamine Type 2 Receptor Binding Potential With Fasting Neuroendocrine Hormones and Insulin Sensitivity in Human Obesity
Open accessAbstract
OBJECTIVE: Midbrain dopamine (DA) neurons, which are involved with reward and motivation, are modulated by hormones that regulate food intake (insulin, leptin, and acyl ghrelin [AG]). We hypothesized that these hormones are associated with deficits in DA signaling in obesity. RESEARCH DESIGN AND METHODS: We assessed the relationships between fasting levels of insulin and leptin, and AG, BMI, and insulin sensitivity index (SI) with the availability of central DA type 2 receptor (D2R). We measured D2R availability using positron emission tomography and [18F]fallypride (radioligand that competes with endogenous DA) in lean (n = 8) and obese (n = 14) females. Fasting hormones were collected prior to scanning and SI was determined by modified oral glucose tolerance test. RESULTS: Parametric image analyses revealed associations between each metabolic measure and D2R. The most extensive findings were negative associations of AG with clusters involving the striatum and inferior temporal cortices. Regional regression analyses also found extensive negative relationships between AG and D2R in the caudate, putamen, ventral striatum (VS), amygdala, and temporal lobes. SI was negatively associated with D2R in the VS, while insulin was not. In the caudate, BMI and leptin were positively associated with D2R availability. The direction of associations of leptin and AG with D2R availability are consistent with their opposite effects on DA levels (decreasing and increasing, respectively). After adjusting for BMI, AG maintained a significant relationship in the VS. We hypothesize that the increased D2R availability in obese subjects reflects relatively reduced DA levels competing with the radioligand. CONCLUSIONS: Our findings provide evidence for an association between the neuroendocrine hormones and DA brain signaling in obese females.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This is consistent with preclinical (40) and clinical (41) studies showing dynamic associations between the changes in neuroendocrine hormones (e.g. insulin, leptin, ghrelin) triggered by food restriction and brain DA signalling and those of recent reports of a relationship between addictive personality and maladaptive eating behaviours following bariatric surgery (42,43).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965 · cited 4×
“The study included 22 females (6 black, 16 white), 8 in the lean group (BMI = 236 2 kg/m2) and 14 in the obese group (BMI = 40 6 5 kg/m2), who were comparable in age (P = 0.904) and scores on the BDI-II (P = 0.430) (Table 1).”
BackgroundInfluentialForman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202 · cited 1×
“(20) were used to assess the significance of clusters of significant correlations.”
MethodWang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · cited 5×
“Our participants were imaged at night after an 8 h fast, while others completed imaging primarily in the morning either with a relatively short fast (minimum2 h) (5) or after an overnight fast (21).”
BackgroundMethodResultInfluentialSelf-citationReward, dopamine and the control of food intake: implications for obesity
Volkow, N. D., Wang, G.-J., & Baler, R. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.001 · Cited by 1,400 · cited 3×
“Therefore, our interpretation of diminished DA levels with obesity is consistent with current hypotheses that obesity is a state of reduced DA signaling in reward and motivation circuits (1).”
BackgroundInfluentialSelf-citationAcute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270 · cited 1×
“These are evolutionarily advanced regions of the neocortex that participate in various cognitive functions, including memory sensory integration, that have been previously implicated in obesity (35) and drug abuse (36).”
BackgroundChanges in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · cited 1×
“The inferior temporal cortex is involved with visual perception (37) but also participates in satiation (38).”
BackgroundLeptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · cited 1×
“Specifically, leptin diminishes VTA DA neuron firing and nucleus accumbens DA release (26), whereas AG increases VTA DA neuron firing and nucleus accumbens DA release (27).”
BackgroundStice, E., Spoor, S., Bohon, C., Veldhuizen, M. G., & Small, D. M. (2008) · Journal of Abnormal Psychology · doi:10.1037/a0013600 · Cited by 779 · cited 1×
“Imaging studies reveal that DA release in the dorsal striatum is associated with pleasure from food intake (3) and that obese individuals have reduced neural activation in the dorsal striatum when they consume highly palatable food compared with lean subjects (4).”
BackgroundSmall, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632
Ghrelin and the short- and long-term regulation of appetite and body weight
Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620 · cited 1×
“Hypothalamic and dopaminergic nuclei are neuroanatomically interconnected (6), and DA neurons in the ventral tegmental area (VTA) [project to ventral striatum (rodent equivalent is the nucleus accumbens]) and substantia nigra (project to dorsal striatum) express receptors for insulin, leptin (2), and AG (7).”
Background
Flagged first, then by citations
Cited by
Sorted by citations
The dopamine motive system: implications for drug and food addiction
Volkow, N. D., Wise, R. A., & Baler, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.130 · Cited by 939
Self-citationThe Neuroscience of Drug Reward and Addiction
Volkow, N. D., Michaelides, M., & Baler, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00014.2018 · Cited by 863
“95, 175).”
Self-citationObesity and addiction: Neurobiological overlaps
Volkow, N. D., Wang, G. ‐., Tomasi, D., & Baler, R. D. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01031.x · Cited by 800
“This is consistent with preclinical (40) and clinical (41) studies showing dynamic associations between the changes in neuroendocrine hormones (e.”
ResultSelf-citationVal‐Laillet, D., Aarts, E., Weber, B., Ferrari, M., Quaresima, V., Stoeckel, L. E., Alonso‐Alonso, M., Audette, M. A., Malbert, C., & Stice, E. M. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.03.016 · Cited by 466
“As a consequence, the choice of a neuromodulation strategy cannot rest on a single criterion (e.g. balance between the severity of disease — e.g. high BMI with comorbidities — and the invasiveness of therapy), but on multiple assessment criteria, of which some of these are directlyrelatedtothepatient 3 sphenotypeandso…”
InfluentialUpadhyay, J., Farr, O. M., Perakakis, N., Ghaly, W., & Mantzoros, C. S. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.004 · Cited by 425
Metadata
- Authors
- Dunn, J. P., Kessler, R. M., Feurer, I. D., Volkow, N. D., Patterson, B. W., Ansari, M. S., Li, R., Marks-Shulman, P., & Abumrad, N. N.
- Affiliations
- Vanderbilt University (US)
- National Institute on Drug Abuse (US)
- Washington University in St. Louis (US)
- Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee
- Corresponding author
- Dunn, Julia P.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2012-04-11
- Volume
- 35
- Issue
- 5
- Pages
- 1105-1111
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3329842
- OpenAlex
- W2003413351
- Cited by
- 148
- References
- 40
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 16 · 2018: 14 · 2017: 13 · 2016: 16 · 2015: 15 · 2014: 17 · 2013: 9 · 2012: 4
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2 CX000943)
- Vanderbilt University
- National Institutes of Health (-015855, 5p60dk020593-31, DK 20593)
- Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases (DK058404, P60-DK020593, R01DK091748, DK 20593, DK 70860, R01DK070860, 56341, P30DK058404, P30DK056341, P30DK020593)
- National Institute of Environmental Health Sciences (K12ES015855)
- National Center for Research Resources (KL2RR024977, TL1RR024978, UL1RR024975)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- dopamine D2 receptor, obesity, insulin sensitivity, leptin, acylated ghrelin, insulin, neuroendocrine hormones, ventral striatum, caudate nucleus, putamen, amygdala, striatum, inferior temporal cortex, female, food intake regulation
- MeSH terms
- Adult, Basal Ganglia, Fasting, Female, Humans, Insulin Resistance, Middle Aged, Obesity, Body Mass Index, Receptors, Dopamine D2, Leptin, Positron-Emission Tomography, Ghrelin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
