Cited by 227Liver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseDiabetes, Cardiovascular Risks, and Lipoproteins

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Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients

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Bozzetto, Lutgarda, Prinster, Anna, Annuzzi, Giovanni, Costagliola, Lucia, Mangione, Anna, Vitelli, Alessandra, Mazzarella, Raffaella, Longobardo, Margaret, Mancini, Marcello, Vigorito, Carlo, Riccardi, Gabriele, Rivellese, Angela A.·2012·Diabetes Care

DOI 10.2337/dc12-0033PMC PMC3379578

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Abstract

OBJECTIVE: To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: With use of a factorial 2 × 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plus metformin treatment were assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high-fiber/low-glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by (1)H NMR. RESULTS: Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS: An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes.

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Authors: Bozzetto, L., Prinster, A., Annuzzi, G., Costagliola, L., Mangione, A., Vitelli, A., Mazzarella, R., Longobardo, M., Mancini, M., Vigorito, C., Riccardi, G., & Rivellese, A. A.
Affiliations: Federico II University Hospital (IT)
Institute of Biostructure and Bioimaging (IT)
University of Naples Federico II (IT)
Corresponding author: Rivellese, Angela A.
ORCID: Bozzetto, Lutgarda
Prinster, Anna
Annuzzi, Giovanni
Vitelli, Alessandra
Mancini, Marcello
Vigorito, Carlo
Riccardi, Gabriele
Rivellese, Angela A.
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2012-06-12
Volume: 35
Issue: 7
Pages: 1429-1435
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/dc12-0033
PMC: PMC3379578
OpenAlex: W1965542427
Cited by: 227
References: 41
Citations by year: 2026: 4 · 2025: 12 · 2024: 17 · 2023: 15 · 2022: 20 · 2021: 19 · 2020: 25 · 2019: 22 · 2018: 22 · 2017: 20 · 2016: 17 · 2015: 6 · 2014: 13 · 2013: 11 · 2012: 4
FWCI: 8.11
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
Locations: Diabetes Care (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: American Diabetes Association
FP7 Food, Agriculture and Fisheries, Biotechnology
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 2 diabetes, hepatic steatosis, liver fat, monounsaturated fatty acids, dietary fat composition, isocaloric diet, aerobic exercise training, dietary fiber, low glycemic index diet, metformin
MeSH terms: Adult, Aged, Diabetes Mellitus, Type 2, Fats, Fatty Acids, Monounsaturated, Fatty Liver, Female, Humans, Liver, Male, Metformin, Middle Aged, Exercise

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Liver Fat Is Reduced by an Isoenergetic MUFA Diet in a Controlled Randomized Study in Type 2 Diabetic Patients

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