Hyperglycemia-induced intracellular depletion of ascorbic acid in human mononuclear leukocytes
Open accessAbstract
It has recently been reported that glucose and its analogues inhibit in vitro ascorbic acid transport across the cell membrane of polymorphonuclear leukocytes and fibroblasts. We have studied the effect of in vivo hyperglycemia on the intracellular ascorbic acid level of mononuclear leukocytes in normal and diabetic human subjects. Administration of an intravenous glucose load resulted in a prompt decrease of mononuclear leukocyte ascorbic acid level in the normal subjects. The rate of its decline correlated closely with the rate of change of plasma glucose. Among the NIDDM subjects in the fasting state, the plasma glucose was high and the leukocyte ascorbic acid level was low when compared with that of the normal subjects. The decrease in the leukocyte ascorbic acid level during disposition of the i.v. glucose load was not statistically significant in the diabetics. The hyperglycemia-induced intracellular depletion of ascorbic acid could be clinically important and requires further evaluation.
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Quercetin at 1 g per day for 21 days failed to attenuate muscle inflammation in ultramarathon runners and trained cyclists.
“Quercetin (1 g/d for 21 d) failed to attenuate muscle inflammation in ultramarathon runners (807) and in trained cyclists (808,809) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [808]
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- Authors
- Chen, M. S., Hutchinson, M. L., Pecoraro, R. E., Lee, W. Y. L., & Labbé, R. F.
- Affiliations
- University of Washington (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1983-11-01
- Volume
- 32
- Issue
- 11
- Pages
- 1078-1081
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2171002936
- Cited by
- 78
- References
- 6
- Citations by year
- 2025: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- hyperglycemia, vitamin C, mononuclear leukocytes, type 2 diabetes, glucose load, plasma glucose, glucose analogs
- MeSH terms
- Adult, Aged, Ascorbic Acid, Blood Glucose, Diabetes Mellitus, Type 2, Humans, Hyperglycemia, Insulin, Male, Middle Aged, Monocytes
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