Cited by 205Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

Brain insulin signalling in metabolic homeostasis and disease

Scherer, Thomas, Sakamoto, Kenichi, Buettner, Christoph·2021·Nature Reviews Endocrinology

Abstract

Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ crosstalk. Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic or intranasal application of insulin provide evidence that brain insulin action might reduce food intake and, more importantly, regulates energy homeostasis by orchestrating nutrient partitioning. This Review discusses the metabolic pathways that are under the control of brain insulin action and explains how brain insulin resistance contributes to metabolic disease in obesity, the metabolic syndrome and type 2 diabetes mellitus.

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Crossref · 10.1038/s41574-021-00498-x

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253 of 253 references verified0 citation errors · 0 not checkable

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Authors
Scherer, T., Sakamoto, K., & Buettner, C.
Affiliations
  • Medical University of Vienna (AT)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
  • Scherer, Thomas
  • Buettner, Christoph
Venue
Nature Reviews Endocrinology
Published
2021-06-09
Volume
17
Issue
8
Pages
468-483
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W3167467420
Cited by
205
References
255
Citations by year
2026: 38 · 2025: 36 · 2024: 61 · 2023: 35 · 2022: 30 · 2021: 5
FWCI
4.15
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
insulin resistance, energy homeostasis, nutrient partitioning, food intake regulation, obesity, metabolic syndrome, type 2 diabetes, hypothalamus, intranasal insulin, organ crosstalk, metabolic disease treatment
MeSH terms
Animals, Brain, Diabetes Mellitus, Type 2, Energy Metabolism, Homeostasis, Humans, Insulin, Insulin Resistance, Metabolic Diseases, Signal Transduction, Metabolic Syndrome

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