Cited by 258Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

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Diabetes and Cardiovascular Disease in a Prospective Population Survey in Japan: The Hisayama Study

Fujishima, Masatoshi, Kiyohara, Yutaka, Kato, Isao, Ohmura, Takao, Iwamoto, Hiromitsu, Nakayama, Keizo, Ohmori, Susumu, Yoshitake, Taketo·1996·Diabetes

DOI 10.2337/diab.45.3.s14

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Abstract

To elucidate the effect of glucose intolerance on cardiovascular disease in the current Japanese population, we performed a 75-g oral glucose tolerance test in 2,427 Hisayama residents aged 40–79 years in 1988, who were free from a previous history of stroke or myocardial infarction, and followed them prospectively for 5 years. The prevalence of diabetes (NIDDM) among men was 13% and that of impaired glucose tolerance (IGT) was 20%; the corresponding values for women were 9 and 19%, respectively. The age- and sex-adjusted incidence of cerebral infarction (6.5 per 1,000 person-years, P 0.01) and coronary heart disease (5.0 per 1,000 person-years, P 0.05) was significantly higher in subjects with NIDDM than in those with normal glucose tolerance (1.9 and 1.6 per 1,000 person-years, respectively). In addition, subjects with IGT and NIDDM had a higher risk of cardiovascular disease including stroke and coronary heart disease than did those with normal glucose tolerance after adjustment for age and sex, namely the relative risk for IGT was 1.9 (95% CI 1.2–3.2), and the relative risk for NIDDM was 3.0 (95% CI 1.8–5.2). These associations remained significant even after controlling for six other risk factors including hypertension in multivariate analysis. Our data suggest that NIDDM is a significant risk factor for both cerebral infarction and coronary heart disease and also that IGT itself is a risk factor for cardiovascular disease in the general Japanese population today.

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Self-citation
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“According to the Hisayama Study [16], onset risk of cerebral infarction and coronary heart disease is three times higher in Japanese diabetic patients than in non-diabetic individuals.”
Background
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“The incidence of CVD is approximately two or three times as high in patients with type 2 diabetes as in agematched controls without diabetes [27, 28], and the risk of CVD increases with the duration of diabetes and with age [29–31].”
Background

Authors: Fujishima, M., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., & Yoshitake, T.
Affiliations: Kyushu University (JP)
ORCID: Kato, Isao
Venue: Diabetes
Publisher: American Diabetes Association
Published: 1996-07-01
Volume: 45
Issue: Supplement_3
Pages: S14-S16
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diab.45.3.s14
OpenAlex: W1987951971
Cited by: 258
References: 0
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 9 · 2018: 16 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 4 · 2013: 17 · 2012: 7
FWCI: 2.94
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 2 diabetes, impaired glucose tolerance, cardiovascular disease, cerebral infarction, coronary artery disease, stroke, oral glucose tolerance test, Hisayama Study, hypertension, cardiovascular risk factors, Japanese population
MeSH terms: Adult, Aged, Alcohol Drinking, Cardiovascular Diseases, Cerebral Infarction, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Humans, Hyperlipidemias, Hypertension, Japan, Male, Middle Aged, Obesity, Risk, Smoking

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Diabetes and Cardiovascular Disease in a Prospective Population Survey in Japan: The Hisayama Study

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