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Cited by 69Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and ResearchDiabetes Treatment and Management

Relationship of elevated casual blood glucose level with coronary heart disease, cardiovascular disease and all-cause mortality in a representative sample of the Japanese population. NIPPON DATA80

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Kadowaki, S., Okamura, T., Hozawa, A., Kadowaki, T., Kadota, A., Murakami, Y., Nakamura, K., Saitoh, S. +6 more·2008·Diabetologia
DOI 10.1007/s00125-007-0915-6
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Abstract

Aims/hypothesis High fasting blood glucose is one of the well-known risk factors for CHD. However, in certain settings, patients cannot always be expected to fast. For example, community screenings for cardiovascular disease (CVD) risk factors in Japan are performed under non-fasting conditions to achieve high participation rates. Thus, we examined a representative cohort of the Japanese population (n=9,444, follow-up period 17.3 years) to clarify whether high casual blood glucose (CBG) can predict CVD mortality.Methods We defined CBG groups as follows: high CBG >or= 11.1 mmol/l or participants with a history of diabetes mellitus; borderline high, 7.77 <or= CBG<11.1 mmol/l; higher normal, 5.22 <or= CBG<7.77 mmol/l); and lower normal, CBG<5.22 mmol/l. The multivariate-adjusted hazard ratios (HRs) for CHD, CVD and all-cause mortality were calculated.Results The crude CHD mortality rate was 0.84 per 1,000 person-years. Age- and sex-adjusted HRs for CHD mortality were high among participants with CBG levels >or= 7.77 mmol/l, regardless of time since last meal. Multivariate-adjusted HRs (95% CI) of CHD mortality in high and borderline high CBG groups were 2.62 (1.46-4.67) and 2.43 (1.29-4.58), respectively. Similar results were observed for both CVD and all-cause mortality. Even within the normal blood glucose range, each 1 mmol/l increase in CBG was associated with a statistically significant increase in the HR for CVD mortality (1.12, 95% CI 1.02-1.22). Population-attributable fractions of the combined groups of high and borderline high CBG for CHD, CVD and all-cause mortality were 12.0, 4.9 and 3.5%, respectively.Conclusions/interpretation Increases in CBG, even within the normal range, predict CVD mortality.

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Authors
Kadowaki, S., Okamura, T., Hozawa, A., Kadowaki, T., Kadota, A., Murakami, Y., Nakamura, K., Saitoh, S., Nakamura, Y., Hayakawa, T., Kita, Y., Okayama, A., Ueshima, H., & for the NIPPON DATA Research Group
Affiliations
  • Shiga University of Medical Science (JP)
  • National Cerebral and Cardiovascular Center (JP)
  • Sapporo Medical University (JP)
  • Kyoto Women's University (JP)
  • Fukushima Medical University (JP)
  • Japan Anti Tuberculosis Association (JP)
Corresponding author
Kadowaki, S.
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2008-01-16
Volume
51
Issue
4
Pages
575-582
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s00125-007-0915-6
OpenAlex
W1969711013
Cited by
69
References
40
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 3 · 2014: 5 · 2013: 7 · 2012: 5
FWCI
4.34
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
coronary heart disease mortality, cardiovascular mortality, all-cause mortality, cardiovascular risk factors, diabetes mellitus, population attributable fraction, Japanese population
MeSH terms
Adult, Aged, Alcohol Drinking, Blood Glucose, Cardiovascular Diseases, Cause of Death, Cholesterol, Coronary Disease, Heart Diseases, Humans, Hyperglycemia, Hypertension, Japan, Middle Aged, Smoking, Cohort Studies, Proportional Hazards Models

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