The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Abstract
The hypothalamus and other regions within the central nervous system (CNS) link the sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular (ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake. The anorectic effect of oleic acid was independent of leptin and was accompanied by a decrease in the hypothalamic expression of neuropeptide Y. The short-chain fatty acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministration of inhibitors of ATP-sensitive K+ channels blunted the effect of oleic acid on glucose production. This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation.
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“pharmacological interventions designed to block LCFA oxidation by increasing malonyl CoA levels (e.g. oleic acid, fatty acid synthase (FAS) inhibitor) in the CNS reduce food intake and HGP (99, 107, 133, 147)”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [133]
In the citing paper
“Although accumulating evidence suggests that leptin (10 -13), insulin (14,15), and nutrient-related signals (16 -18) in the CNS improve hepatic insulin sensitivity”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [16]
Citations
Cites
Central nervous system control of food intake
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Role of leptin in the neuroendocrine response to fasting
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Environmental Contributions to the Obesity Epidemic
Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,258
Signals That Regulate Food Intake and Energy Homeostasis
Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,177
Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors
Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004
Rossetti, L., Smith, D. J., Shulman, G. I., Papachristou, D. N., & DeFronzo, R. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112981 · Cited by 824
Self-citationA nutrient-sensing pathway regulates leptin gene expression in muscle and fat
Wang, J., Liu, R., Hawkins, M. A., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 823
Self-citationA possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736
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Malonyl-CoA, fuel sensing, and insulin resistance
Ruderman, N. B., Saha, A. K., Vavvas, D. G., & Witters, L. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e1 · Cited by 649
Research works printed but not linked: 1
- Obici S, Feng Z, Rossetti L: Hypothalamic insulin action is required for the inhibitory effects of systemic insulin on hepatic glucose fluxes (Abstract). Proceedings of the Keystone Symposium. Obesity and the Regulation of Energy Homeostasis. Taos, NM, 24 February 2001 to 1 March 2001
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Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
Energy Metabolism in the Liver
Rui, L. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130024 · Cited by 2,401
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,672
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
Metadata
- Authors
- Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-02-01
- Volume
- 51
- Issue
- 2
- Pages
- 271-275
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2148366635
- Cited by
- 654
- References
- 27
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 19 · 2022: 14 · 2021: 19 · 2020: 22 · 2019: 19 · 2018: 20 · 2017: 34 · 2016: 28 · 2015: 41 · 2014: 36 · 2013: 36 · 2012: 30
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK20541, DK-45024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oleic acid, long-chain fatty acids, glucose production, dietary intake, anorectic effect, hypothalamus, neuropeptide Y, octanoic acid, short-chain fatty acids, ATP-sensitive potassium channels, nutrient sensing, intracerebroventricular administration
- MeSH terms
- Adenosine Triphosphate, Animals, Eating, Glucose, Hypothalamus, Injections, Intraventricular, Insulin, Male, Neuropeptide Y, Sulfonylurea Compounds, Potassium Channels, Rats, Sprague-Dawley, Oleic Acid, Third Ventricle, Potassium Channel Blockers, Rats
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