The Concept of Selective Leptin Resistance

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Neural Control of Renal Function*

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Chronic Leptin Infusion Increases Arterial Pressure

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Sympathetic Activation in Obese Normotensive Subjects

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Pathophysiological role of leptin in obesity-related hypertension

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Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic

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The Central Melanocortin System and Energy Homeostasis

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Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice

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Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system

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Afferent signals from leptin sensors in the white adipose tissue of the epididymis, and their reflex effect in the rat

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Interaction between leptin and sympathetic nervous system in hypertension

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Reflex effects from leptin sensors in the white adipose tissue of the epididymis to the efferent activity of the sympathetic and vagus nerve in the rat

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Leptin injection into white adipose tissue elevates renal sympathetic nerve activity dose-dependently through the afferent nerves pathway in rats

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Obesity, Adipose Tissue and Vascular Dysfunction

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Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

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Cardiac remodeling in obesity

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Mechanisms of obesity-induced hypertension

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Leptin resistance

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The cellular and molecular bases of leptin and ghrelin resistance in obesity

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Leptin and Cardiovascular Disease

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Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance

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Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

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Leptin Signaling and Obesity

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Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2012 · Cited by 319 · see citing works

Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance

Enriori, P. J., Sinnayah, P., Simonds, S. E., Rudaz, C. G., & Cowley, M. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2336-11.2011 · Cited by 318 · see citing works

Leptin and hyperleptinemia - from friend to foe for cardiovascular function

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Selective Insulin and Leptin Resistance in Metabolic Disorders

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Obesity and asthma

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Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset

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Leptin receptor action and mechanisms of leptin resistance

Münzberg, H., Björnholm, M., Bates, S. H., & Myers, M. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4432-1 · Cited by 260 · see citing works

The role of leptin in leptin resistance and obesity

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The Role of the Autonomic Nervous System in the Pathophysiology of Obesity

Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 244 · see citing works

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

Rahmouni, K., Fath, M. A., Seo, S., Thedens, D. R., Berry, C. J., Weiss, R. M., Nishimura, D. Y., & Sheffield, V. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32357 · Cited by 227 · see citing works

Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications

Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 228 · see citing works

Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications

Mark, A. L., Correia, M. L. G., Rahmouni, K., & Haynes, W. G. (2002) · Journal of Hypertension · doi:10.1097/00004872-200207000-00001 · Cited by 215 · see citing works

Role of leptin in blood pressure regulation and arterial hypertension

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The role of leptin in leptin resistance and obesity

Enriori, P. J., Evans, A. E., Sinnayah, P., & Cowley, M. A. (2006) · Obesity · Cited by 197 · see citing works

A Randomized Trial of Continuous Subcutaneous Insulin Infusion and Intensive Injection Therapy in Type 1 Diabetes for Patients With Long-Standing Poor Glycemic Control

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Obesity and Asthma

Weiss, S. T., & Shore, S. A. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200303-403ws · Cited by 186 · see citing works

Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin

Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-14-05998.2003 · Cited by 185 · see citing works

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

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Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice

Huby, A.-C., Otvos, L. J., & de Chantemèle, E. J. B. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06642 · Cited by 168 · see citing works

Selective leptin resistance revisited

Mark, A. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00180.2013 · Cited by 162 · see citing works

Obesity-related hypertension: possible pathophysiological mechanisms

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Exposure to a High-Fat Diet Alters Leptin Sensitivity and Elevates Renal Sympathetic Nerve Activity and Arterial Pressure in Rabbits

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Early life programming of obesity and metabolic disease

Cottrell, E. C., & Ozanne, S. E. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.017 · Cited by 155 · see citing works

Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease

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Leptin, obesity and cardiovascular disease

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Murine models for pharmacological studies of the metabolic syndrome

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Chronic Sympathetic Activation

Seals, D. R., & Bell, C. (2004) · Diabetes · doi:10.2337/diabetes.53.2.276 · Cited by 142 · see citing works

Cardiovascular Responses Evoked by Leptin Acting on Neurons in the Ventromedial and Dorsomedial Hypothalamus

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Leptin and hypertension in obesity

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Melanocortin-4 Receptor Mediates Chronic Cardiovascular and Metabolic Actions of Leptin

Tallam, L. S., da Silva, A. A., & Hall, J. E. (2006) · Hypertension · doi:10.1161/01.hyp.0000227966.36744.d9 · Cited by 133 · see citing works

Effects of HIV protease inhibitor therapy on lipid metabolism

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From big fat cells to high blood pressure: a pathway to obesity-associated hypertension

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Selective Resistance to Central Neural Administration of Leptin in Agouti Obese Mice

Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2002) · Hypertension · doi:10.1161/hy0202.102836 · Cited by 126 · see citing works

Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress

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Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy

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Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome

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Intracellular Mechanisms Involved in Leptin Regulation of Sympathetic Outflow

Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000048342.54392.40 · Cited by 120 · see citing works

A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity

Hilzendeger, A. M., Morgan, D. A., Brooks, L. A., Dellsperger, D., Liu, X., Grobe, J. L., Rahmouni, K., Sigmund, C. D., & Mark, A. L. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00974.2011 · Cited by 117 · see citing works

Oxidative stress, nitric oxide production, and renal sodium handling in leptin-induced hypertension

Bełtowski, J., Wójcicka, G., Marciniak, A., & Jamroz, A. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.029 · Cited by 118 · see citing works

Regulation of Vascular Function and Insulin Sensitivity by Adipose Tissue: Focus on Perivascular Adipose Tissue

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Role of leptin in obesity‐related hypertension

Haynes, W. G. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031237 · Cited by 117 · see citing works

Intra-abdominal Adiposity and Individual Components of the Metabolic Syndrome in Adolescence

Syme, C. A., Abrahamowicz, M., Leonard, G. T., Perron, M., Pitiot, A., Qiu, X., Richer, L., Totman, J. J., Veillette, S., Xiao, Y., et al. (2008) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.162.5.453 · Cited by 115 · see citing works

Leptin and the Cardiovascular System

Rahmouni, K. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.225 · Cited by 110 · see citing works

Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases

Balasubramanian, P., Hall, D., & Subramanian, M. (2018) · GeroScience · doi:10.1007/s11357-018-0048-5 · Cited by 109 · see citing works

Autonomic Nervous System in Obesity and Insulin-Resistance—The Complex Interplay between Leptin and Central Nervous System

Russo, B., Menduni, M., Borboni, P., Picconi, F., & Frontoni, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105187 · Cited by 110 · see citing works

Impact of Leptin-Mediated Sympatho-Activation on Cardiovascular Function in Obese Mice

Belin de Chantemèle, E. J., Mintz, J. D., Rainey, W. E., & Stepp, D. W. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.168427 · Cited by 103 · see citing works

PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance

Crosson, S. M., Khan, A. H., Printen, J. A., Pessin, J. E., & Saltiel, A. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17975 · Cited by 95 · see citing works

Mechanisms mediating renal sympathetic activation to leptin in obesity

Morgan, D. A., Thedens, D. R., Weiss, R., & Rahmouni, K. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90324.2008 · Cited by 89 · see citing works

Developmental programming of energy balance and the metabolic syndrome

Cottrell, E. C., & Ozanne, S. E. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005447 · Cited by 87 · see citing works

Neural regulation of blood pressure by leptin and the related peptides

Matsumura, K., Tsuchihashi, T., Fujii, K., & Iida, M. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00116-2 · Cited by 82 · see citing works

Differential Mechanisms and Development of Leptin Resistance in A/J Versus C57BL/6J Mice during Diet-Induced Obesity

Prpić, V., Watson, P. M., Frampton, I. C., Sabol, M. A., Jezek, G. E., & Gettys, T. W. (2003) · Endocrinology · doi:10.1210/en.2002-220835 · Cited by 82 · see citing works

Neuroprotective effects of leptin in the context of obesity and metabolic disorders

Davis, C., Mudd, J., & Hawkins, M. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.012 · Cited by 83 · see citing works

Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity

Morrison, C. D., Huypens, P., Stewart, L. K., & Gettys, T. W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.005 · Cited by 80 · see citing works

Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice

Nohara, K., Waraich, R. S., Liu, S., Ferron, M., Waget, A., Meyers, M. S., Karsenty, G., Burcelin, R., & Mauvais-Jarvis, F. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2012 · Cited by 77 · see citing works

Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes

Palanivel, R., Eguchi, M., Shuralyova, I., Coe, I. R., & Sweeney, G. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.020 · Cited by 72 · see citing works

Modulation of central leptin sensitivity and energy balance in a rat model of diet‐induced obesity

Fam, B. C., Morris, M. J., Hansen, M. J., Kebede, M. A., Andrikopoulos, S., Proietto, J., & Thorburn, A. W. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00653.x · Cited by 71 · see citing works

Soluble Leptin Receptor and Soluble Receptor‐Bound Fraction of Leptin in the Metabolic Syndrome

Sandhofer, A., Laimer, M. W., Ebenbichler, C. F., Kaser, S., Paulweber, B., & Patsch, J. R. (2003) · Obesity Research · doi:10.1038/oby.2003.106 · Cited by 69 · see citing works

Leptin protects H9c2 rat cardiomyocytes from H2O2‐induced apoptosis

Eguchi, M., Liu, Y.-T., Shin, E., & Sweeney, G. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06465.x · Cited by 67 · see citing works

Circumventricular organs: Targets for integration of circulating fluid and energy balance signals?

Mimee, A., Smith, P., & Ferguson, A. V. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.012 · Cited by 66 · see citing works

Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance

Balaskó, M., Soós, S., Székely, M., & Pétervári, E. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.08.006 · Cited by 63 · see citing works

Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY3–36 but resistant to ghrelin

Martin, N. M., Small, C., Sajedi, A., Patterson, M., Ghatei, M. A., & Bloom, S. R. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802646 · Cited by 61 · see citing works

Leptin-Replacement Therapy in Lipodystrophy

Wolfsdorf, J. I., Sadeghi‐Nejad, A., & Senior, B. (2002) · New England Journal of Medicine · doi:10.1056/nejm200206203462515 · Cited by 61 · see citing works

Intermittent Fasting Induces Hypothalamic Modifications Resulting in Low Feeding Efficiency, Low Body Mass and Overeating

Chausse, B., Solon, C., da Silva, C. C. C., dos Reis, I. G. M., Manchado-Gobatto, F. D. B., Gobatto, C. A., Velloso, L. A., & Kowaltowski, A. J. (2014) · Endocrinology · doi:10.1210/en.2013-2057 · Cited by 58 · see citing works

The Brain Subfornical Organ Mediates Leptin-induced Increases in Renal Sympathetic Activity but not its Metabolic Effects

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Leptin Selectively Regulates Nutrients Metabolism in Nile Tilapia Fed on High Carbohydrate or High Fat Diet

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