Hypothalamic control of adipose tissue
Abstract
A detailed appreciation of the control of adipose tissue whether it be white, brown or brite/beige has never been more important to the development of a framework on which to build therapeutic strategies to combat obesity. This is because 1) the rate of fatty acid release into the circulation from lipolysis in white adipose tissue (WAT) is integrally important to the development of obesity, 2) brown adipose tissue (BAT) has now moved back to center stage with the realization that it is present in adult humans and, in its activated form, is inversely proportional to levels of obesity and 3) the identification and characterization of "brown-like" or brite/beige fat is likely to be one of the most exciting developments in adipose tissue biology in the last decade. Central to all of these developments is the role of the CNS in the control of different fat cell functions and central to CNS control is the integrative capacity of the hypothalamus. In this chapter we will attempt to detail key issues relevant to the structure and function of hypothalamic and downstream control of WAT and BAT and highlight the importance of developing an understanding of the neural input to brite/beige fat cells as a precursor to its recruitment as therapeutic target.
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Adipose metabolism is finely regulated by a neuroendocrine network, with the hypothalamus-SNS-adrenergic receptor (AR) being the prime regulatory axis.
“Adipose metabolism is finely regulated by a neuroendocrine network, with the hypothalamus-SNS-adrenergic receptor (AR) being the prime regulatory axis [8].”
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Neuroendocrine Control of Brown Adipocytes: Functions, Beiging, Whitening and AutophagyPreprint
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- Authors
- Stefanidis, A., Wiedmann, N. M., Adler, E. S., & Oldfield, B. J.
- Affiliations
- Monash University (AU)
- Weizmann Institute of Science (IL)
- Corresponding author
- Oldfield, B.J.
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 28
- Issue
- 5
- Pages
- 685-701
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W2123266654
- Cited by
- 22
- References
- 107
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- hypothalamus, adipose tissue, white adipose tissue, brown adipose tissue, obesity, lipolysis, fatty acid release, hypothalamic circuits, obesity treatment
- MeSH terms
- Adipose Tissue, Animals, Humans, Hypothalamus, Lipolysis, Adipocytes
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