A Reduced-Fat Diet and Aerobic Exercise in J apanese A mericans With Impaired Glucose Tolerance Decreases Intra-Abdominal Fat and Improves Insulin Sensitivity but not β-Cell Function
Open accessAbstract
Lifestyle modification reduces the risk of developing type 2 diabetes and may have its effect through improving insulin sensitivity, β-cell function, or both. To determine whether diet and exercise improve insulin sensitivity and/or β-cell function and to evaluate these effects over time, we quantified insulin sensitivity and the acute insulin response to glucose (AIRg) in 62 Japanese Americans (age 56.5 ± 1.3 years; mean ± SE) with impaired glucose tolerance (IGT) who were randomized to the American Heart Association (AHA) Step 2 diet plus endurance exercise (n = 30) versus the AHA Step 1 diet plus stretching (n = 32) for 24 months. β-Cell function (disposition index [DI]) was calculated as Si × AIRg, where Si is the insulin sensitivity index. The incremental area under the curve for glucose (incAUCg) was calculated from a 75-g oral glucose tolerance test. Intra-abdominal fat (IAF) and subcutaneous fat (SCF) areas were measured by computed tomography. At 24 months, the Step 2/endurance group had lower weight (63.1 ± 2.4 vs. 71.3 ± 2.9 kg; P = 0.004) and IAF (75.0 ± 7.9 vs. 112.7 ± 10.4 cm2; P = 0.03) and SCF (196.5 ± 18.0 vs. 227.7 ± 19.9 cm2; P < 0.001) areas, greater Si (4.7 ± 0.5 vs. 3.3 ± 0.3 × 10−5 min · pmol−1 · l−1; P = 0.01), and a trend toward lower AIRg (294.9 ± 50.0 vs. 305.4 ± 30.0 pmol/l; P = 0.06) and incAUCg (8,217.3 ± 350.7 vs. 8,902.0 ± 367.2 mg · dl−1 · 2 h−1; P = 0.08) compared with the Step 1/stretching group after adjusting for baseline values. There was no difference in the DI (P = 0.7) between the groups. Si was associated with changes in weight (r = −0.426, P = 0.001) and IAF (r = −0.395, P = 0.003) and SCF (r = −0.341, P = 0.01) areas. Thus, the lifestyle modifications decreased weight and central adiposity and improved insulin sensitivity in Japanese Americans with IGT. However, such changes did not improve β-cell function, suggesting that this degree of lifestyle modifications may be limited in preventing type 2 diabetes over the long term.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple epidemiological cohort studies have demonstrated a protective association between higher levels of physical activity and CRF and lower risk of diabetes mellitus.
“Multiple epidemiological cohort studies have demonstrated the protective association between higher levels of PA and CRF and lower risk of DM [ 86 , 87 ].”
From Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise training, prescriptive methods, and special patient populations (2022) · cites this paper as [87]
The introduction (section “T”; page unavailable) reports that several randomized studies found lower diabetes incidence after combined diet-and-exercise interventions in people with impaired glucose tolerance. It does not report multiple epidemiological cohort studies showing that higher physical activity or cardiorespiratory fitness is associated with lower diabetes risk; the Results report improved aerobic capacity, not diabetes incidence. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 4× · see citing works
“Our study was shorter in duration, used an isocaloric diet comprised of 30% of total calories as fat, with 7% being saturated fat, and recorded less weight loss than in the Finnish Diabetes Prevention Study (4) or the DPP at 24 months (3) (average 2.”
BackgroundResultInfluentialFundamentals of Biostatistics.
(1969) · Annals of Internal Medicine · doi:10.7326/0003-4819-70-4-873 · Cited by 4,573 · see citing works
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320 · see citing works
The Continuing Epidemics of Obesity and Diabetes in the United States
Mokdad, A. H. (2001) · JAMA · doi:10.1001/jama.286.10.1195 · Cited by 2,730 · see citing works
Simulation Study of Confounder-Selection Strategies
Maldonado, G., & Greenland, S. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116813 · Cited by 2,491 · see citing works
Fundamentals of Clinical Trials
Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2015) · doi:10.1007/978-3-319-18539-2 · Cited by 2,237 · see citing works
Morgan, C. R., & Lazarow, A. (1963) · Diabetes · doi:10.2337/diab.12.2.115 · Cited by 2,212 · see citing works
Analysing controlled trials with baseline and follow up measurements
Vickers, A. J., & Altman, D. G. (2001) · BMJ · doi:10.1136/bmj.323.7321.1123 · Cited by 2,116 · see citing works
Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940 · see citing works
Quantitative estimation of insulin sensitivity.
Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874 · see citing works
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405 · see citing works
Self-citationIrwin, M. L., Yasui, Y., Ulrich, C. M., Bowen, D., Rudolph, R. E., Schwartz, R. S., Yukawa, M., Aiello, E., Potter, J. D., & McTiernan, A. (2003) · JAMA · doi:10.1001/jama.289.3.323 · Cited by 517 · cited 14× · see citing works
“Moreover, we found that the reductions in weight and IAF fat, but not percent body fat or abdominal SCF, were associated with the 24-month change in -cell function.”
ResultInfluentialSelf-citationDuncan, G. E., Perri, M. G., Theriaque, D. W., Hutson, A. D., Eckel, R. H., & Stacpoole, P. W. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.557 · Cited by 425 · see citing works
Mourier, A., Gautier, J.-F., Kerviler, E. D., Bigard, A. X., Villette, J.-M., Garnier, J.-P., Duvallet, A., Guezennec, C. Y., & Cathelineau, G. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.385 · Cited by 361 · see citing works
Yamanouchi, K., Shinozaki, T., Chikada, K., Nishikawa, T., Ito, K., Shimizu, S., Ozawa, N., Suzuki, Y., Maeno, H., Kato, K., et al. (1995) · Diabetes Care · doi:10.2337/diacare.18.6.775 · Cited by 330 · see citing works
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J. P., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.11.1663 · Cited by 328 · see citing works
Self-citationLoss of abdominal fat and metabolic response to exercise training in obese women
Després, J., Pouliot, M. C., Moorjani, S., Nadeau, A., Tremblay, A., Lupien, P. J., Thériault, G., & Bouchard, C. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.2.e159 · Cited by 292 · see citing works
The effect of intensive endurance exercise training on body fat distribution in young and older men
Schwartz, R. S., Shuman, W. P., Larson, V., Cain, K. C., Fellingham, G. W., Beard, J. C., Kahn, S. E., Stratton, J. R., Cerqueira, M. D., & Abrass, I. B. (1991) · Metabolism · doi:10.1016/0026-0495(91)90239-s · Cited by 275 · see citing works
Self-citationBeard, J. C., Bergman, R. N., Ward, W. K., & Porte, D. (1986) · Diabetes · doi:10.2337/diab.35.3.362 · Cited by 247 · see citing works
Hayashi, T., Boyko, E., Leonetti, D., McNeely, M., Newell-Morris, L., Kahn, S., & Fujimoto, W. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.650 · Cited by 245 · see citing works
Self-citationIntensive Lifestyle Changes Are Necessary to Improve Insulin Sensitivity
McAuley, K. A., Williams, S., Mann, J. I., Goulding, A., Chisholm, A. W., Wilson, N. C., Story, G., McLay-Cooke, R. T., Harper, M. J., & Jones, I. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.445 · Cited by 212 · see citing works
Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging
Kahn, S. E., Larson, V., Beard, J. C., Cain, K. C., Fellingham, G. W., Schwartz, R. S., Veith, R. C., Stratton, J. R., Cerqueira, M., & Abrass, I. B. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.6.e937 · Cited by 198 · see citing works
Self-citationUusitupa, M., Lindi, V., Louheranta, A., Salopuro, T., Lindström, J., Tuomilehto, J., & for the Finnish Diabetes Prevention Study Group (2003) · Diabetes · doi:10.2337/diabetes.52.10.2532 · Cited by 196 · see citing works
Schaefer, E. J., Lichtenstein, A. H., Lamon-Fava, S., Mcnamara, J., Schaefer, M. M., Rasmussen, H., & Ordovás, J. (1995) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.1995.03530180044028 · Cited by 185 · see citing works
Abnormal Body Fat Distribution Detected by Computed Tomography in Diabetic Men
Shuman, W. P., Morris, L., Leonetti, D. L., WAHL, P. W., Moceri, V. M., Moss, A. A., & Fujimoto, W. Y. (1986) · Investigative Radiology · doi:10.1097/00004424-198606000-00007 · Cited by 148 · see citing works
Self-citationShadid, S., & Jensen, M. D. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3148 · Cited by 148 · see citing works
Improved beta-cell function after standardized weight reduction in severely obese subjects.
Guldstrand, M., Bo, A.-R., & Adamson, U. (2003) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00325.2002 · Cited by 126 · see citing works
Diet of second-generation Japanese-American men with and without non-insulin-dependent diabetes
Tsunehara, C. H., Leonetti, D., & Fujimoto, W. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.4.731 · Cited by 111 · see citing works
Self-citationAlam, S., Stolinski, M., Pentecost, C., Boroujerdi, M. A., Jones, R. H., Sönksen, P. H., & Umpleby, A. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031036 · Cited by 98 · see citing works
Colman, E. G., Katzel, L. I., Rogus, E. M., Coon, P. J., Muller, D. C., & Goldberg, A. P. (1995) · Metabolism · doi:10.1016/0026-0495(95)90153-1 · Cited by 97 · see citing works
Incidence of Diabetes in American Indians of Three Geographic Areas
Lee, E. T., Welty, T. K., Cowan, L. D., Wang, W., Rhoades, D. A., Devereux, R. B., Go, O. T., Fabsitz, R. R., & Howard, B. V. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.49 · Cited by 89 · see citing works
Ross, R., Rissanen, J., & Hudson, R. (1996) · PubMed · Cited by 89 · see citing works
Liao, D., Asberry, P. J., Shofer, J. B., Callahan, H. S., Matthys, C. C., Boyko, E. J., Leonetti, D. L., Kahn, S. E., Austin, M. A., Newell, L., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.9.1504 · Cited by 81 · see citing works
Self-citationEffect of mild exercise training on glucose effectiveness in healthy men.
Nishida, Y., Higaki, Y., Tokuyama, K., Fujimi, K., Kiyonaga, A., Shindo, M., Sato, Y., & Tanaka, H. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1008 · Cited by 75 · see citing works
Diet-Induced Weight Loss Is Associated with an Improvement in β-Cell Function in Older Men
Utzschneider, K. M., Carr, D. B., Barsness, S. M., Kahn, S. E., & Schwartz, R. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031827 · Cited by 73 · see citing works
Self-citationChou, P., Li, C., Wu, G.-S., & Tsai, S. (1998) · Diabetes Care · doi:10.2337/diacare.21.7.1183 · Cited by 66 · see citing works
Beard, J. C., Bergman, R. N., Ward, W. K., et al. (1986) · Diabetes · doi:10.2337/diabetes.35.3.362 · Cited by 58 · see citing works
Abbate, S. L., Fujimoto, W. Y., Brunzell, J. D., & Kahn, S. E. (1993) · Metabolism · doi:10.1016/0026-0495(93)90086-4 · Cited by 40 · see citing works
Self-citationUsefulness of a branching treadmill protocol for evaluation of cardiac functional capacity
Schauer, J. E., & Hanson, P. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90622-9 · Cited by 22 · see citing works
Effect of exercise training on doses of oral agents and insulin.
FUJINUMA, H., Abe, R., Yamazaki, T., Seino, H., KIKUCHI, H., Hoshino, T., Hirano, R., & Yoshida, S. (1999) · Diabetes Care · doi:10.2337/diacare.22.10.1754 · Cited by 12 · see citing works
Growth of postmenarcheal girls from three ethnic groups
Cronk, C. E., Schall, J. I., Hediger, M. L., & Scholl, T. O. (1996) · American Journal of Human Biology · doi:10.1002/(sici)1520-6300(1996)8:1 · Cited by 5 · see citing works
Self-citationAccess to Care in Regionalized Health Care Systems-Reply
Anderson, G. M. (1996) · JAMA · doi:10.1001/jama.1996.03530340022021 · Cited by 2 · see citing works
Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7
Flagged first, then by citations
Cited by
Sorted by citations
Pancreatic Fat Content and β-Cell Function in Men With and Without Type 2 Diabetes
Tushuizen, M. E., Bunck, M. C. M., Pouwels, P. J. W., Bontemps, S., van Waesberghe, J. H. T., Schindhelm, R. K., Mari, A., Heine, R. J., & Diamant, M. (2007) · Diabetes Care · doi:10.2337/dc07-0326 · Cited by 402 · see citing works
Balk, E. M., Earley, A., Raman, G., Avendano, E. A., Pittas, A. G., & Remington, P. L. (2015) · Annals of Internal Medicine · doi:10.7326/m15-0452 · Cited by 371 · see citing works
Ismail, I., Keating, S. E., Baker, M. K., & Johnson, N. A. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00931.x · Cited by 345 · see citing works
Exercise or exercise and diet for preventing type 2 diabetes mellitus
Orozco, L. J., Buchleitner, A. M., Giménez‐Pérez, G., Figuls, M. R. I., Richter, B., & Mauricio, D. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003054.pub3 · Cited by 327 · see citing works
Hemmingsen, B., Gimenez-Perez, G., Mauricio, D., Roqué i Figuls, M., Metzendorf, M.-I., & Richter, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003054.pub4 · Cited by 316 · see citing works
Low-Dose Physiological Growth Hormone in Patients With HIV and Abdominal Fat Accumulation
Lo, J. (2008) · JAMA · doi:10.1001/jama.300.5.509 · Cited by 200 · see citing works
Prevention and treatment of obesity with lifestyle interventions: review and meta-analysis
Galani, C., & Schneider, H. (2007) · Sozial- und Präventivmedizin · doi:10.1007/s00038-007-7015-8 · Cited by 176 · see citing works
Dietary advice for treatment of type 2 diabetes mellitus in adults
Nield, L., Moore, H., Hooper, L., Cruickshank, K., Vyas, A., Whittaker, V., & Summerbell, C. D. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004097.pub4 · Cited by 177 · see citing works
The role of physical activity in the management of impaired glucose tolerance: a systematic review
Yates, T., Khunti, K., Bull, F., Gorely, T., & Davies, M. J. (2007) · Diabetologia · doi:10.1007/s00125-007-0638-8 · Cited by 161 · see citing works
Franklin, B. A., Eijsvogels, T. M. H., Pandey, A., Quindry, J., & Toth, P. P. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100425 · Cited by 121 · see citing works
Body Size and Shape Changes and the Risk of Diabetes in the Diabetes Prevention Program
Fujimoto, W. Y., Jablonski, K. A., Bray, G. A., Kriska, A. M., Barrett-Connor, E. L., Haffner, S. M., Hanson, R. L., Hill, J. O., Hubbard, V. S., Stamm, E. R., et al. (2007) · Diabetes · doi:10.2337/db07-0009 · Cited by 117 · see citing works
Self-citationLifestyle intervention in individuals with normal versus impaired glucose tolerance
Schäfer, S., Kantartzis, K., Machann, J., Venter, C., Niess, A. M., Schick, F., Machicao, F. E., Häring, H.-U., Fritsche, A., & Stefan, N. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01820.x · Cited by 107 · see citing works
Association of 20-Year Changes in Cardiorespiratory Fitness With Incident Type 2 Diabetes
Carnethon, M. R., Sternfeld, B., Schreiner, P. J., Jacobs, D. R., Lewis, C. E., Liu, K., & Sidney, S. (2009) · Diabetes Care · doi:10.2337/dc08-1971 · Cited by 99 · see citing works
Lifestyle intervention for prevention of diabetes: determinants of success for future implementation
Roumen, C., Blaak, E. E., & Corpeleijn, E. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00181.x · Cited by 95 · see citing works
Hofsø, D., Jenssen, T. G., Bollerslev, J., Ueland, T., Godang, K., Stümvoll, M., Sandbu, R., Røislien, J., & Hjelmesaeth, J. S. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0804 · Cited by 83 · see citing works
Arad, A. D., DiMenna, F. J., Thomas, N., Tamis‐Holland, J. E., Weil, R. M., Geliebter, A., & Albu, J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00306.2015 · Cited by 82 · see citing works
Weber, M. B., Oza‐Frank, R. B., Staimez, L. R., Ali, M. K., & Narayan, K. M. V. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150630 · Cited by 69 · see citing works
Chang, A. M., Smith, M. J., Bloem, C. J., Gałecki, A. T., Halter, J. B., & Supiano, M. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1803 · Cited by 64 · see citing works
Walking to Work Is an Independent Predictor of Incidence of Type 2 Diabetes in Japanese Men
Satō, K., Hayashi, T., Kambe, H., Nakamura, Y., Harita, N., Endo, G., & Yoneda, T. (2007) · Diabetes Care · doi:10.2337/dc07-0090 · Cited by 64 · see citing works
Papandreou, C., Schiza, S. E., Bouloukaki, I., Hatzis, C., Kafatos, A. G., Siafakas, N. M., & Tzanakis, Ν. (2011) · European Respiratory Journal · doi:10.1183/09031936.00103411 · Cited by 64 · see citing works
Balducci, S., Zanuso, S., Massarini, M., Corigliano, G., Nicolucci, A., Missori, S., Cavallo, S., Cardelli, P., Alessi, E., Pugliese, G., et al. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.07.006 · Cited by 59 · see citing works
Guess, N. D. (2018) · Nutrients · doi:10.3390/nu10091245 · Cited by 57 · see citing works
Yarizadeh, H., Eftekhar, R., Anjom-Shoae, J., Speakman, J. R., & Djafarian, K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa090 · Cited by 56 · see citing works
Lin, E., Liang, Z., Frediani, J., Davis, S., Sweeney, J., Ziegler, T., Phillips, L., & Gletsu-Miller, N. (2010) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00405.2010 · Cited by 50 · see citing works
Gong, Q., Kang, J.-F., Ying, Y., Li, H., Zhang, X., Wu, Y., & Xu, G. (2015) · Internal Medicine · doi:10.2169/internalmedicine.54.2745 · Cited by 55 · see citing works
Risk Factors for Type 2 Diabetes: Lessons Learned from Japanese Americans in Seattle
Fujimoto, W., Boyko, E., Hayashi, T., Kahn, S., Leonetti, D., McNeely, M., & Shuman, W. (2012) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2012.00195.x · Cited by 62 · see citing works
Self-citationClark, J. (2016) · Biology of Sport · doi:10.5604/20831862.1212974 · Cited by 50 · see citing works
de Mello, V. D., Lindström, J., Eriksson, J. G., Ilanne‐Parikka, P., Keinanen-Kiukaanniemi, S. M., Sundvall, J., Laakso, M., Tuomilehto, J. O., & Uusitupa, M. I. J. (2011) · Diabetes Care · doi:10.2337/dc11-1272 · Cited by 50 · see citing works
Graco, M., Garrard, J., & Jasper, A. (2009) · Health Promotion Journal of Australia · doi:10.1071/he09020 · Cited by 47 · see citing works
Abe, T., Song, J. S., Bell, Z. W., Wong, V. H. Y., Spitz, R. W., Yamada, Y., & Loenneke, J. P. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00942-1 · Cited by 36 · see citing works
Ivey, S. L., Tseng, W., Kurtovich, E. M., Weir, R. C., Liu, J., Song, H., Wang, M. D., & Hubbard, A. (2012) · Diabetes Spectrum · doi:10.2337/diaspect.25.2.93 · Cited by 33 · see citing works
Piché, M.-È., Lemieux, S., Corneau, L., Nadeau, A., Bergeron, J., & Weisnagel, S. J. (2007) · Metabolism · doi:10.1016/j.metabol.2007.04.002 · Cited by 31 · see citing works
Park, S. K., Ryoo, J., Oh, C., Choi, J., & Jung, J. Y. (2018) · European Journal of Endocrinology · doi:10.1530/eje-17-0868 · Cited by 30 · see citing works
Diatetic and Exercise Therapy against Diabetes Mellitus
Jia, Y. (2009) · International Conference on Intelligent Networks and Intelligent Systems · doi:10.1109/icinis.2009.177 · Cited by 30 · see citing works
Exercise Interventions to Prevent and Manage Type 2 Diabetes: Physiological Mechanisms
Dela, F., Prats, C., & Helge, J. W. (2014) · Medicine and sport science/Medicine and sport · doi:10.1159/000357334 · Cited by 21 · see citing works
Dhillon, J., Jacobs, A., Flores, S. O., & Rios, L. K. D. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac002 · Cited by 20 · see citing works
Self-Reported Physical Activity Is Associated With β-Cell Function in Mexican American Adults
Chen, Z., Black, M. H., Watanabe, R. M., Trigo, E., Takayanagi, M., Lawrence, J. M., Buchanan, T. A., & Xiang, A. H. (2012) · Diabetes Care · doi:10.2337/dc12-1485 · Cited by 20 · see citing works
Tushuizen, M. E., Bunck, M. C. M., Pouwels, P. J. W., Bontemps, S., Mari, A., & Diamant, M. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0424 · Cited by 16 · see citing works
Lifestyle Interventions and the Prevention and Treatment of Type 2 Diabetes
Weber, M. B., Twombly, J. G., Narayan, K. M. V., & Phillips, L. S. (2010) · American Journal of Lifestyle Medicine · doi:10.1177/1559827610375531 · Cited by 16 · see citing works
Fujimoto, W. (2016) · Journal of Diabetes Investigation · doi:10.1111/jdi.12539 · Cited by 12 · see citing works
Self-citationZheng, L., Wu, J., Wang, G., Persuitte, G. M., Ma, Y., Zou, L., Zhang, L., Zhao, M., Wang, J., Lan, Q., et al. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.128 · Cited by 13 · see citing works
Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review
Zhang, S., Wei, Y., & Wang, C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127229 · Cited by 12 · see citing works
Goto, M., Morita, A., Goto, A., Deura, K., Sasaki, S., Aiba, N., Shimbo, T., Terauchi, Y., Miyachi, M., Noda, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057964 · Cited by 12 · see citing works
Jancey, J. M., Lee, A. H., James, A. P., Howat, P. A., Hills, A. P., Anderson, A. S., Tran, V. D., & Blackford, K. (2020) · Australian and New Zealand Journal of Public Health · doi:10.1111/1753-6405.13036 · Cited by 12 · see citing works
Do we need to target ‘prediabetic’ hypertensive patients?
Segura, J., Campo, C., Ruilope, L. M., & Rodicio, J. L. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000191907.11606.cc · Cited by 12 · see citing works
Effects of different weight loss percentages on moderate to severe obstructive sleep apnoea syndrome
Papandreou, C., Hatzis, C., & Fragkiadakis, G. A. (2015) · Chronic Respiratory Disease · doi:10.1177/1479972315587516 · Cited by 8 · see citing works
Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors?
Tappy, L., & D’Alessio, D. A. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232907.76859.1c · Cited by 7 · see citing works
Nguyen, A., Tadano, M., Im, B., Kim, M. T., & Nguyen, T. H. (2024) · Nursing Open · doi:10.1002/nop2.70083 · Cited by 4 · see citing works
Onishi, Y., Hayashi, T., Satō, K., Leonetti, D. L., Kahn, S. E., Fujimoto, W. Y., & Boyko, E. J. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.045 · Cited by 2 · see citing works
Self-citationExercise-Induced Pancreatic Islet Adaptations in Health and Disease
Grassiolli, S., Boschero, A. C., Carneiro, E. M., & Zoppi, C. C. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_32 · Cited by 2 · see citing works
Waist measurement as an aid to type II diabetes screening among Asian Americans
Ando, E., & Sin, M.-K. (2017) · Perspectives in Public Health · doi:10.1177/1757913916676771
Exercise-Induced Pancreatic Islet Adaptations in Health and Disease
Zoppi, C. C., Sabrina, G., Carlos, B. A., & Magalhães, C. E. (2013) · Springer eBooks · doi:10.1007/978-94-007-6884-0_32-3 · Cited by 1 · see citing works
Fujimoto, W. Y., Jablonski, K. A., Bray, G. A., Kriska, A. M., Barrett-Connor, E. L., Haffner, S. M., Hanson, R. L., Hill, J. O., Hubbard, V. S., Stamm, E. R., et al. (2007) · Cited by 1 · see citing works
Self-citationPatrones de actividad física y su relación con sobrepeso y obesidad en mujeres
Gallegos, C., & Faustina, L. (2007)
Romero, H., & Cunha, F. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Prevention of Type 2 and Gestational Diabetes
Hamman, R. F., & Dabelea, D. (2010) · doi:10.1002/9780470682807.ch5
Regulation of Fluid-phase Uptake in Podocytes by Albumin-associated Lipids
Chung, J.-J. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7862dfb
Alayón, A. N., & Mosquera, M. (2008) · Universidad Industrial de Santander
Influencia de la prediabetes en el pronóstico cardiovascular del paciente hipertenso
Solís, E. G., Donaire, J. A. G., Urioste, L. M. R., & de la Morena, J. S. (2006) · Hipertensión · doi:10.1016/s0212-8241(06)71729-7
Lee, E., Kim, H., Harada, K., Takaizumi, K., & Nakamura, Y. (2009) · Journal of Japan Society of Sports Industry · doi:10.5997/sposun.19.197
Zmiany rozmiaru i budowy ciała a ryzyko rozwoju cukrzycy w badaniu Diabetes Prevention Program
Fujimoto, W. Y., Jablonski, K. A., Bray, G. A., Kriska, A. M., Barrett-Connor, E. L., Haffner, S. M., Hanson, R. L., Hill, J. O., Hubbard, V. S., Stamm, E. R., et al. (2007) · Via Medica Journals
Self-citationThe role of fermentable carbohydrates on appetite regulation in humans
Daud, M. (2012) · Spiral (Imperial College London) · doi:10.25560/14767
BRIDGING DIABETOLOGY AND CARDIOLOGY
Després, J. (2010)
Satō, K., Hayashi, T., Kambe, H., Nakamura, Y., Harita, N., Endo, G., & Telegraph, N. (2007)
Jayarani, M. J. V., & Thamilarasa, D. P. M. (2014) · Pondicherry Journal of Nursing · doi:10.5005/pjn-7-3-52
Current literature in diabetes
(2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.604
Moriyama, K., Masuda, Y., Suzuki, N., Yamada, C., Kishimoto, N., Takashimizu, S., Akira, K. U. B. O., & Nishizaki, Y. (2022) · Health Evaluation and Promotion · doi:10.7143/jhep.2022-20
Arazi, H., Bagherpour, F., & Tinsley, G. M. (2026) · Biological Research For Nursing · doi:10.1177/10998004261460028
- Authors
- Carr, D. B., Utzschneider, K. M., Boyko, E. J., Asberry, P. J., Hull, R. L., Kodama, K., Callahan, H. S., Matthys, C. C., Leonetti, D. L., Schwartz, R. S., Kahn, S. E., & Fujimoto, W. Y.
- Affiliations
- University of Washington (US)
- General Clinical Research Center, Seattle, Washington
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-02-01
- Volume
- 54
- Issue
- 2
- Pages
- 340-347
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120769341
- Cited by
- 69
- References
- 45
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- University of Washington (DK17047, DK-35816, RR-00037)
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-35816, K24DK002654, DK48152, DK 02654, R01DK048152, DK-17047, P30DK035816, P30DK017047)
- National Center for Research Resources (K23RR016066, RR 16066, RR00037)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- impaired glucose tolerance, type 2 diabetes prevention, reduced-fat diet, aerobic exercise, endurance exercise, lifestyle modification, insulin sensitivity, beta-cell function, acute insulin response, intra-abdominal fat, subcutaneous adipose tissue, disposition index, Japanese Americans, weight loss, insulin sensitivity index, oral glucose tolerance test
- MeSH terms
- Abdomen, Adipose Tissue, Blood Glucose, Female, Glucose Tolerance Test, Humans, Insulin, Islets of Langerhans, Japan, Male, Middle Aged, Regression Analysis, Weight Loss, Exercise, Body Mass Index, Glucose Intolerance, Diet, Fat-Restricted
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
