CoChat
Sign Up
Cited by 31Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiabetes Management and Research

Measuring insulin sensitivity in postmenopausal women covering a range of glucose tolerance: comparison of indices derived from the oral glucose tolerance test with the euglycemic-hyperinsulinemic clamp

Piché, Marie-Ève, Lemieux, Simone, Corneau, Louise, Nadeau, André, Bergeron, Jean, Weisnagel, S. John·2007·Metabolism
DOI 10.1016/j.metabol.2007.04.002
Open this paper in CoChat — free account

Abstract

This study compares indices of insulin sensitivity derived from fasting and oral glucose tolerance test (OGTT) glucose and insulin measurements, with respect to the reference measure (M/I), obtained from the euglycemic-hyperinsulinemic clamp, in postmenopausal women with varying glucose tolerance status. Fasting plasma insulin index, homeostasis model assessment index, and OGTT-derived indices (insulin 120-minute, Matsuda, metabolic clearance rate [MCR] of glucose, insulin sensitivity [ISI], and Cederholm indices) were calculated and compared with the M/I value in 112 postmenopausal women. All indices examined were significantly correlated with M/I (0.28 < or = r(2) < or = 0.56). Association studies revealed that on average, 48% of women were grouped in the same tertile of insulin sensitivity when using M/I and fasting plasma insulin index, and 54% when using M/I and insulin 120-minute index. However, concordance with M/I tertiles were 57%, 58%, 64%, 64%, and 68% for homeostasis model assessment, Matsuda, MCR, ISI, and Cederholm indices, respectively. Finally, correlation coefficients between M/I and insulin sensitivity indices were generally lower in women with normal glucose tolerance compared with women with impaired glucose tolerance or type 2 diabetes mellitus. These results suggest that in postmenopausal women, surrogate indices of insulin sensitivity obtained from OGTT data and incorporating a measurement of body weight or body mass index) (Cederholm, ISI, and MCR indices) appear to be superior to those without OGTT data or body weight-body mass index measurements and, therefore, could offer a better estimate of insulin sensitivity, allowing an improved clinical evaluation of this population at higher risk of cardiovascular disease and type 2 diabetes mellitus.

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2007.04.002

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Piché, M.-È., Lemieux, S., Corneau, L., Nadeau, A., Bergeron, J., & Weisnagel, S. J.
Affiliations
  • Centre hospitalier de l'Université Laval (CA)
  • Université Laval (CA)
Corresponding author
Weisnagel, S. John
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2007-09
Volume
56
Issue
9
Pages
1159-1166
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2007.04.002
OpenAlex
W2036044659
Cited by
31
References
32
Citations by year
2025: 1 · 2021: 1 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 1
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
insulin sensitivity, postmenopausal women, oral glucose tolerance test, hyperinsulinemic-euglycemic clamp, insulin sensitivity index, Matsuda index, HOMA, glucose metabolic clearance rate, impaired glucose tolerance, type 2 diabetes, body mass index, surrogate indices
MeSH terms
Aged, Blood Glucose, Female, Glucose Tolerance Test, Health Status Indicators, Humans, Insulin Resistance, Middle Aged, Glucose Clamp Technique, Prevalence, Postmenopause, Glucose Intolerance, Metabolic Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review