Cited by 269Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

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Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion

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Fan, WuQiang, Yanase, Toshihiko, Nomura, Masatoshi, Okabe, Taijiro, Goto, Kiminobu, Sato, Takashi, Kawano, Hirotaka, Kato, Shigeaki, Nawata, Hajime·2005·Diabetes

DOI 10.2337/diabetes.54.4.1000

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Abstract

Androgen receptor (AR) null male mice (ARL−/Y) revealed late-onset obesity, which was confirmed by computed tomography–based body composition analysis. ARL−/Y mice were euphagic compared with the wild-type male (ARX/Y) controls, but they were also less dynamic and consumed less oxygen. Transcript profiling indicated that ARL−/Y mice had lower transcripts for the thermogenetic uncoupling protein 1, which was subsequently found to be ligand-dependently activated by AR. We also found enhanced secretion of adiponectin, which is insulin sensitizing, from adipose tissue and a relatively lower expression of peroxisome proliferator–activated receptor-γ in white adipose tissue in comparison to ARX/Y mice. Both factors might explain why the overall insulin sensitivity of ARL−/Y mice remained intact, despite their apparent obesity. The results revealed that AR plays important roles in male metabolism by affecting the energy balance, and it is negative to both adiposity and insulin sensitivity.

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Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114
Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,351
Increased adipose tissue in male and female estrogen receptor-α knockout mice
Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., & Cooke, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12729 · Cited by 1,282
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955
Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial
Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2734 · Cited by 837 · cited 1×
“This supports a previous suggestion that testosterone inhibits adiponectin secretion from adipocytes (35,36).”
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Rodríguez‐Cuenca, S., Gianotti, M., Roca, P., & Proenza, A. M. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.01.005 · Cited by 15
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Authors: Fan, W., Yanase, T., Nomura, M., Okabe, T., Goto, K., Sato, T., Kawano, H., Kato, S., & Nawata, H.
Affiliations: Kyushu University (JP)
The University of Tokyo (JP)
ORCID: Yanase, Toshihiko
Nomura, Masatoshi
Sato, Takashi
Kawano, Hirotaka
Kato, Shigeaki
Nawata, Hajime
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2005-04-01
Volume: 54
Issue: 4
Pages: 1000-1008
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.54.4.1000
OpenAlex: W2027264386
Cited by: 269
References: 45
Citations by year: 2026: 6 · 2025: 11 · 2024: 15 · 2023: 8 · 2022: 18 · 2021: 13 · 2020: 11 · 2019: 6 · 2018: 18 · 2017: 21 · 2016: 17 · 2015: 18 · 2014: 16 · 2013: 15 · 2012: 11
FWCI: 5.99
Type: journal article
Language: en
Open access: green
pure.teikyo.jp
Licence: cc-by-nc-nd
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: androgen receptor, late-onset obesity, energy expenditure, lipolysis, insulin sensitivity, adiponectin secretion, UCP1, thermogenesis, PPARγ, white adipose tissue, energy balance, euphoria
MeSH terms: Uncoupling Protein 1, Adipose Tissue, Aging, Animals, Body Weight, Carrier Proteins, Energy Metabolism, Insulin, Insulin Resistance, Ion Channels, Lipolysis, Male, Membrane Proteins, Obesity, Oxygen Consumption, Receptors, Androgen, Gene Expression, Mice, Knockout, Mitochondrial Proteins, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin

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Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion

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