Correlation of sex hormone and androgen receptor with diabetes mellitus in elderly men
Open accessAbstract
AIM: To investigate sex hormone and androgen receptor (AR) levels and to evaluate their relationship with diabetes mellitus (DM) in senile men. METHODS: The cross-sectional study included 492 elderly men comprising 104 healthy subjects (mean age 71.4 ± 5.2 years), 259 subjects without DM (71.5 ± 5.0 years) and 129 DM patients (73.0 ± 6.3 years). Plasma concentrations of total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulphate, sex hormone-binding globulin (SHBG), estradiol (E(2)), luteinising hormone) and follicle-stimulating hormone (FSH) were determined. AR-positive cells were measured by flow cytometry. RESULTS: TT concentrations were significantly lower in the DM group (13.8 ± 4.7 nmol/l) than in the healthy (17.1 ± 6.1 nmol/l) and non-diabetes groups (15.8 ± 6.0 nmol/l; all P < 0.01). FT, SHBG, AR-positive proportion (AR%) and AR fluorescence intensity showed a decreasing trend among the healthy, non-DM and DM groups, but the differences were not significant. TT, E(2), E(2)/testosterone and SHBG were negatively correlated with blood glucose. SHBG was positively correlated and TT and AR% were negatively correlated with the course of DM. Logistic multiple regression analysis revealed that age, waist/hip ratio, FSH, SHBG and AR% are potential risk factors for DM. CONCLUSIONS: Low levels of TT, SHBG and AR may be potential risk factors for DM in elderly men.
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Androgen receptor expression is lower in elderly males with DM2.
“It has been shown that AR expression is lower in elderly males with DM2 [16].”
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Groti, K., Žuran, I., Antonič, B., Foršnarič, L., & Pfeifer, M. (2018) · The Aging Male · doi:10.1080/13685538.2018.1468429 · Cited by 117 · see citing works
- Authors
- Cao, J., Li, J., Hao, W., Li, X., Wang, H., Liu, L., Zhu, B., & Guo, Z.
- Affiliations
- Chinese PLA General Hospital (CN)
- Corresponding author
- Cao, Jian
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2011-05-17
- Volume
- 14
- Issue
- 3
- Pages
- 162-167
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- OpenAlex
- W2022325404
- Cited by
- 21
- References
- 25
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Aging Male (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, sex hormones, androgen receptor, older men, total testosterone, sex hormone-binding globulin, estradiol, luteinizing hormone, follicle-stimulating hormone, diabetes risk factors, blood glucose, aging
- MeSH terms
- Age Factors, Aged, Blood Glucose, Diabetes Mellitus, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Male, Receptors, Androgen, Risk Factors, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Logistic Models, Waist-Hip Ratio
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