Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion

Obesity and the regulation of energy balance

Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,114

Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator

Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076

Towards a molecular understanding of adaptive thermogenesis

Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,351

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., & Cooke, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12729 · Cited by 1,282

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955

Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial

Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911

Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2734 · Cited by 837 · cited 1×

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity

Jones, M. E. E., Thorburn, A. W., Britt, K. L., Hewitt, K. N., Wreford, N. G., Proietto, J., Oz, O. K., Leury, B. J., Robertson, K. M., Yao, S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12735 · Cited by 729

Adipocytokines and Insulin Resistance

Pittas, A. G., Joseph, N. A., & Greenberg, A. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031005 · Cited by 513

Andropause: clinical implications of the decline in serum testosterone levels with aging in men

Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490

Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years

Kyle, U., Genton, L., Hans, D., Karsegard, L., Slosman, D., & Pichard, C. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601198 · Cited by 442

Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity

Mauras, N., Hayes, V. Y., Welch, S., Rini, A., Helgeson, K., Dokler, M. L., Veldhuis, J. D., & Urban, R. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4892 · Cited by 419

Transdermal Testosterone Gel Improves Sexual Function, Mood, Muscle Strength, and Body Composition Parameters in Hypogonadal Men

Wang, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2839 · Cited by 359

Suppressive function of androgen receptor in bone resorption

Kawano, H., Sato, T., Yamada, T., Μatsumoto, T., Sekine, K., Watanabe, T., Nakamura, T., Fukuda, T., Yoshimura, K., Yoshizawa, T., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533500100 · Cited by 318

Brain masculinization requires androgen receptor function

Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Aihara, K.-I., Krust, A., Yamada, T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305303101 · Cited by 303

Invited Review: Uncoupling proteins and thermoregulation

Argyropoulos, G. A., & Harper, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00994.2001 · Cited by 258

The Effects of Androgens on the Regulation of Lipolysis in Adipose Precursor Cells

Xu, X., Pergola, G. D., & Björntorp, P. A. (1990) · Endocrinology · doi:10.1210/endo-126-2-1229 · Cited by 202

Late onset of obesity in male androgen receptor-deficient (AR KO) mice

Sato, T., Μatsumoto, T., Yamada, T., Watanabe, T., Kawano, H., & Kato, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02774-2 · Cited by 196

Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy

Lanfranco, F., Zitzmann, M., Simoni, M., & Nieschlag, E. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02007.x · Cited by 178

Insulin Resistance in Nonobese Patients with Polycystic Ovary Syndrome

Toprak, S., Yönem, A., Çakır, B., Güler, S., Azal, Ö., Özata, M., & Çorakçı, A. (2001) · Hormone Research in Paediatrics · doi:10.1159/000049972 · Cited by 152

Andropause

Vermeulen, A. (2000) · Maturitas · doi:10.1016/s0378-5122(99)00075-4 · Cited by 147

Cellular and Molecular Characterization of the Adipose Phenotype of the Aromatase-Deficient Mouse

Misso, M. L., Murata, Y., Boon, W. C., Jones, M. E. E., Britt, K. L., & Simpson, E. R. (2003) · Endocrinology · doi:10.1210/en.2002-221123 · Cited by 142

The influence of androgens on insulin resistance

Shoupe, D., & Løbo, R. A. (1984) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47716-2 · Cited by 136

Activation of Peroxisome Proliferator-Activated Receptor-γ and Retinoid X Receptor Inhibits Aromatase Transcription via Nuclear Factor-κB

Fan, W., Yanase, T., Morinaga, H., Mu, Y.-M., Nomura, M., Okabe, T., Goto, K., Harada, N., & Nawata, H. (2004) · Endocrinology · doi:10.1210/en.2004-1046 · Cited by 107

Using quantitative CT to assess adipose distribution in adult men with acquired hypogonadism.

Katznelson, L. J., Rosenthal, D. I., Rosol, M. S., Anderson, E. J., Hayden, D. L., Schoenfeld, D., & Klibanski, A. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.170.2.9456958 · Cited by 95

Neurochemical identity of neurones expressing oestrogen and androgen receptors in sheep hypothalamus

Herbison, A. E. (2019) · Bioscientifica Proceedings · doi:10.1530/biosciprocs.3.021 · Cited by 78

Testosterone substitution of hypogonadal men prevents the age-dependent increases in body mass index, body fat and leptin seen in healthy ageing men: results of a cross-sectional study

Rolf, C., von Eckardstein, S., Koken, U. H., & Nieschlag, E. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460505 · Cited by 72

Androgen-activating enzymes in the central nervous systemProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

Poletti, A., & Martini, L. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00150-2 · Cited by 61

Flutamide-Metformin Plus Ethinylestradiol-Drospirenone for Lipolysis and Antiatherogenesis in Young Women with Ovarian Hyperandrogenism: The Key Role of Early, Low-Dose Flutamide

Ibáñez, L., Valls, C., Cabré, S., & de Zegher, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0047 · Cited by 61

Protein Kinase A Potentiates Adrenal 4 Binding Protein/Steroidogenic Factor 1 Transactivation by Reintegrating the Subcellular Dynamic Interactions of the Nuclear Receptor with Its Cofactors, General Control Nonderepressed-5/Transformation/ Transcription Domain-Associated Protein, and Suppressor, Dosage-Sensitive Sex Reversal-1: a Laser Confocal Imaging Study in Living KGN Cells

Fan, W., Yanase, T., Wu, Y., Kawate, H., Saitoh, M., Oba, K., Nomura, M., Okabe, T., Goto, K., Yanagisawa, J., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0110 · Cited by 61

Polycystic ovary syndrome and insulin resistance: Thrifty genes struggling with over-feeding and sedentary life style?

Holte, J. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350784 · Cited by 52

Androgen receptor gene repeats and indices of obesity in older adults

Gustafson, D., Wen, M.-M., & Koppanati, B. M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802191 · Cited by 48

Influence of Growth Hormone and Androgens on Body Composition in Adults

Jørgensen, J. O. L., Vahl, N., Hansen, T. B., Fisker, S., Hagen, C., & Christiansen, J. S. (2008) · Hormone Research · doi:10.1159/000184766 · Cited by 34

Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain

Zeitler, P. S., Vician, L. J., Chowen, J. A., Argente, J., Tannenbaum, G. S., Clifton, D. K., & Steiner, R. A. (1990) · Metabolism · doi:10.1016/0026-0495(90)90209-u · Cited by 29

Another role highlighted for estrogens in the male: Sexual behavior

Simpson, E. R., & Davis, S. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011526097 · Cited by 27

Masculinization of growth hormone (GH) secretory pattern by dihydrotestosterone is associated with augmentation of hypothalamic somatostatin and GH-releasing hormone mRNA levels in ovariectomized adult rats

Hasegawa, O., Sugihara, H., Minami, S., & Wakabayashi, I. (1992) · Peptides · doi:10.1016/0196-9781(92)90077-g · Cited by 26

Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs

Avogaro, A., Nosadini, R., Doria, A., Tremolada, C., Baccaglini, U., Ambrosio, F., Merkel, C., Nosadini, A., Trevisan, R., & Fioretto, P. (1990) · Metabolism · doi:10.1016/0026-0495(90)90146-4 · Cited by 20

Effect of alloxan diabetes on kidney growth in intact and castrated mice

Broulik, P. D., & Schreiber, V. (1982) · European Journal of Endocrinology · doi:10.1530/acta.0.0990109 · Cited by 7

The influence of testosterone on the synthesis and degradation rate of various RNA species in the mouse kidney

Avdalović, N., & Bates, M. (1975) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(75)90097-0 · Cited by 6

The Human Obesity Gene Map: The 2005 Update

Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119

Androgen Receptor Structure, Function and Biology: From Bench to Bedside.

(2016) · Europe PMC (PubMed Central) · Cited by 623

Sex differences in the physiology of eating

Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513

Testosterone and obesity

Kelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487

Regulation of adipocyte lipolysis

Frühbeck, G., Méndez-Giménez, L., Fernández‐Formoso, J. A., Fernández, S., & Rodrı́guez, A. (2014) · Nutrition Research Reviews · doi:10.1017/s095442241400002x · Cited by 447

Androgens and metabolic syndrome: Lessons from androgen receptor knock out (ARKO) mice

Yanase, T., Fan, W., Kyoya, K., Min, L., Takayanagi, R., Kato, S., & Nawata, H. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.017 · Cited by 101

Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice

Rubinow, K., Houston, B., Wang, S., Goodspeed, L., Ogimoto, K., Morton, G., McCarty, C., Braun, R., & Page, S. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_54_17 · Cited by 7

Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue

Yu, I.-C. I., Lin, H., Liu, N.-C., Wang, R.-S., Sparks, J. D., Yeh, S., & Chang, C. (2008) · Endocrinology · doi:10.1210/en.2007-0516 · Cited by 82

Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor

Lin, H., Xu, Q., Yeh, S., Wang, R.-S., Sparks, J. D., & Chang, C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1717 · Cited by 176

Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on

Homeostasis, G., & Walker, B. R. (2016)