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Cited by 31

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Loss of Heparan N-Sulfotransferase in Diabetic Liver

Williams, Kevin Jon, Liu, Ming-Lin, Zhu, Yanqing, Xu, Xiangsheng, Davidson, William R., McCue, Peter, Sharma, Kumar·2005·Diabetes
DOI 10.2337/diabetes.54.4.1116
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Abstract

The basis for accelerated atherosclerosis in diabetes is unclear. Diabetes is associated with loss of heparan sulfate (HS) from the liver, which may impede lipoprotein clearance and thereby worsen atherosclerosis. To study hepatic HS loss in diabetes, we examined regulation of HS N-deacetylase/N-sulfotransferase-1 (NDST), a key enzyme in hepatic HS biosynthesis. Hepatic NDST mRNA, protein, and enzymatic activity were suppressed by >50% 2 weeks after induction of type 1 diabetes in rats. Treatment of diabetic rats with enalapril, an ACE inhibitor, had no effect on hyperglycemia or hepatic NDST mRNA levels, yet increased hepatic NDST protein and enzymatic activity. Similar results were obtained in diabetic animals treated with losartan, which blocks the type 1 receptor for angiotensin II (AngII). Consistent with these findings, diabetic livers exhibited increased ACE expression, and addition of AngII to cultured hepatoma cells reduced NDST activity and protein. We conclude that diabetes substantially suppresses hepatic NDST mRNA, protein, and enzymatic activity. AngII contributes to suppression of NDST protein and enzymatic activity, whereas mRNA suppression occurs independently. Suppression of hepatic NDST may contribute to diabetic dyslipidemia, and stimulation of NDST activity by AngII inhibitors may provide cardiovascular protection.

Overview

Integrity signals

Registry

Crossref · 10.2337/diabetes.54.4.1116

Cites

53 of 53 references verified0 citation errors · 0 not checkable

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Verification

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Citations

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Metadata

Authors
Williams, K. J., Liu, M.-L., Zhu, Y., Xu, X., Davidson, W. R., McCue, P., & Sharma, K.
Venue
Diabetes
Publisher
American Diabetes Association
Published
2005-04-01
Volume
54
Issue
4
Pages
1116-1122
ISSN
  • 0012-1797
  • 1939-327X
DOI
10.2337/diabetes.54.4.1116
Cited by
31
References
53
Language
en

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.