Improvement in Glucose Tolerance After 1 Wk of Exercise in Patients With Mild NIDDM
Abstract
We investigated the effects of 1 wk of intense exercise on glucose tolerance in 10 men with abnormal glucose tolerance [7 had mild non-insulin-dependent diabetes mellitus (NIDDM), and 3 had impaired glucose tolerance]. The 7 days of exercise did not result in significant changes in body weight or maximal oxygen uptake. Plasma glucose concentration at 120 min averaged 227 ± 23 mg/dl in an oral glucose tolerance test (OGTT) before and 170 ± 18 mg/dl after the 7 days of exercise (P < .001). There was a 36% reduction in the area under the glucose tolerance curve. Plasma insulin concentration at 120 min of the OGTT averaged 172 ± 27μU/ml before and 106 ± 13 μU/ml after 7 days of exercise (P < .001); the area under the insulin curve was decreased by 32%. In contrast to the response to 7 days of exercise, one bout of exercise did not result in an improvement in glucose tolerance. These results provide evidence that regularly performed, vigorous exercise can be effective in decreasing insulin resistance and improving glucose tolerance within 7 days in some patients with mild NIDDM.
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Seven days of aerobic training increases whole-body insulin sensitivity in 22- and 58-year-old men and women, 66-year-old men and women with BMI 33, 60- to 80-year-old men and women, and type 2 diabetes patients.
“Seven days of aerobic training increases whole body insulin sensitivity in 22- and 58-yr-old men and women (244), 66-yr-old men and women (BMI = 33) (486); 60- to 80-yr old men and women (112), and T2D patients (274, 444).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [444]
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Cites
Burstein, R., Polychronakos, C., Toews, C. J., MacDougall, J. D., Guyda, H. J., & Posner, B. I. (1985) · Diabetes · doi:10.2337/diab.34.8.756 · Cited by 171 · see citing works
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Exercise and Physical Activity for Older Adults
Chodzko-Zajko, W. J., Proctor, D. N., Fiatarone Singh, M. A., Minson, C. T., Nigg, C. R., Salem, G. J., & Skinner, J. S. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181a0c95c · Cited by 5,153 · see citing works
Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575 · see citing works
(2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200007000-00024 · Cited by 604 · see citing works
Invited Review: Effects of acute exercise and exercise training on insulin resistance
Henriksen, E. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01219.2001 · Cited by 535 · see citing works
The acute versus the chronic response to exercise
THOMPSON, P. D., CROUSE, S. F., GOODPASTER, B., KELLEY, D., MOYNA, N., & PESCATELLO, L. (2001) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200106001-00012 · Cited by 508 · see citing works
Insulin action and insulin resistance in human skeletal muscle
Zierath, J. R., Krook, A., & Wallberg-Henriksson, H. (2000) · Diabetologia · doi:10.1007/s001250051457 · Cited by 367 · see citing works
Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance
Hawley, J. A. (2004) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.505 · Cited by 344 · see citing works
Dela, F., Larsen, J. J., Mikines, K. J., Ploug, T., Petersen, L. N., & Galbo, H. (1995) · Diabetes · doi:10.2337/diab.44.9.1010 · Cited by 286 · see citing works
Kirwan, J. P., Solomon, T. P. J., Wojta, D. M., Staten, M. A., & Holloszy, J. O. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00210.2009 · Cited by 218 · see citing works
Self-citationSolomon, T. P., Haus, J. M., Kelly, K. R., Cook, M. D., Filion, J., Rocco, M., Kashyap, S. R., Watanabe, R. M., Barkoukis, H., & Kirwan, J. P. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29771 · Cited by 165 · see citing works
Winnick, J. J., Sherman, W. M., Habash, D. L., Stout, M. B., Failla, M. L., Belury, M. A., & Schuster, D. P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1524 · Cited by 153 · see citing works
Henriksen, E. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.002 · Cited by 136 · see citing works
Exercise and the Treatment of Type 2 Diabetes Mellitus: An Update
Eriksson, J. G. (1999) · Sports Medicine · doi:10.2165/00007256-199927060-00003 · Cited by 113 · see citing works
Interactions between insulin and exercise
Richter, E. A., Sylow, L., & Hargreaves, M. (2021) · Biochemical Journal · doi:10.1042/bcj20210185 · Cited by 99 · see citing works
Hersey, W. C., Graves, J. E., Pollock, M. L., Gingerich, R., Shireman, R. B., Heath, G. W., Spierto, F., McCole, S. D., & Hagberg, J. M. (1994) · Metabolism · doi:10.1016/0026-0495(94)90265-8 · Cited by 81 · see citing works
Self-citationGarekani, E. T., Mohebbi, H., Kraemer, R. R., & Fathi, R. (2011) · Peptides · doi:10.1016/j.peptides.2011.01.027 · Cited by 77 · see citing works
Skeletal muscle and insulin sensitivity: pathophysiological alterations
Ryder, J. (2001) · Frontiers in bioscience · doi:10.2741/ryder · Cited by 73 · see citing works
Cononie, C. C., Goldberg, A. P., Rogus, E., & Hagberg, J. M. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb07487.x · Cited by 58 · see citing works
Self-citationArciero, P. J., Smith, D. L., & Calles-Escandon, J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.4.1365 · Cited by 50 · see citing works
Effect of a single vs multiple bouts of exercise on glucose control in women with type 2 diabetes
Baynard, T., Franklin, R. M., Goulopoulou, S., Carhart, R., & Kanaley, J. A. (2005) · Metabolism · doi:10.1016/j.metabol.2005.02.015 · Cited by 48 · see citing works
Biological mechanisms of stroke prevention by physical activity in type 2 diabetes
Agosti, V., Graziano, S., Artiaco, L., & Sorrentino, G. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01080.x · Cited by 25 · see citing works
- Authors
- Rogers, M. A., Yamamoto, C., King, D. S., Hagberg, J. M., Ehsani, A. A., & Holloszy, J. O.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1988-09-01
- Volume
- 11
- Issue
- 8
- Pages
- 613-618
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2047243213
- Cited by
- 201
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 10 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 2 · 2012: 9
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p60am020579-08)
- National Institute on Aging (AG05562, AG 00078)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- glucose tolerance, exercise training, type 2 diabetes, impaired glucose tolerance, insulin resistance, plasma insulin, oral glucose tolerance test, acute exercise, VO2max, body weight
- MeSH terms
- Blood Glucose, Cholesterol, Diabetes Mellitus, Type 2, Glucose Tolerance Test, Humans, Insulin, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Exercise
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