Biological mechanisms of stroke prevention by physical activity in type 2 diabetes
Open accessAbstract
The principal modifiable risk factors for stroke are hypertension, diabetes mellitus, hypercholesterolaemia, hyperhomocysteinaemia, smoking and limited physical activity. However, it is not clear whether physical inactivity is a risk factor per se, or because it predisposes to pathological conditions that are risk factors for stroke. The limited availability of effective therapeutic approaches for stroke emphasizes the crucial role of prevention of risk factors. The global burden associated with type 2 diabetes is large and continues to grow. Convincing epidemiologic data support the role of physical activity in preventing type 2 diabetes. The increasing evidence of physical activity in preventing diabetic complications, including stroke, has generated interest in the molecular basis underlying these beneficial effects. The aim of the present review is to discuss the biological mechanisms underlying the effect of physical activity in preventing stroke in type 2 diabetes.
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Exercise primarily lowers hyperglycemia by improving glucose sensitivity and by mechanisms that interfere directly with endothelial metabolism.
“exercise primarily acts to lower hyperglycemia by improving glucose sensitivity and mechanisms that interfere directly with endothelial metabolism (4).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [4]
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Lack of Exercise Is a Major Cause of Chronic Diseases
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- Authors
- Agosti, V., Graziano, S., Artiaco, L., & Sorrentino, G.
- Affiliations
- Parthenope University of Naples (IT)
- Corresponding author
- Sorrentino, G.
- ORCID
- Agosti, V.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Hindawi Limited
- Published
- 2009-04
- Volume
- 119
- Issue
- 4
- Pages
- 213-223
- ISSN
- 0001-6314 (ISSN-L)
- 1600-0404
- OpenAlex
- W1974593340
- Cited by
- 25
- References
- 129
- Citations by year
- 2024: 2 · 2020: 4 · 2018: 4 · 2016: 3 · 2015: 2 · 2013: 2 · 2012: 4
- FWCI
- 0.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Neurologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Aisberg (University of Bergamo) (submittedVersion)
- CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
- Funders
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Regione Campania
- Regione Lazio
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- physical activity, stroke prevention, type 2 diabetes, biological mechanisms, diabetes mellitus, stroke risk factors, diabetes complications, hypertension, hypercholesterolemia, hyperhomocysteinemia, smoking
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Endothelium, Exercise Therapy, Glycogen, Humans, Insulin, Nitric Oxide, Risk Factors, Signal Transduction, Exercise, Muscle, Skeletal, Stroke, Lipid Metabolism, Glucose Transporter Type 4
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