Cited by 25Physical Activity and HealthDiabetes, Cardiovascular Risks, and LipoproteinsAcute Ischemic Stroke Management

Biological mechanisms of stroke prevention by physical activity in type 2 diabetes

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Agosti, V., Graziano, S., Artiaco, L., Sorrentino, G.·2009·Acta Neurologica Scandinavica

Abstract

The principal modifiable risk factors for stroke are hypertension, diabetes mellitus, hypercholesterolaemia, hyperhomocysteinaemia, smoking and limited physical activity. However, it is not clear whether physical inactivity is a risk factor per se, or because it predisposes to pathological conditions that are risk factors for stroke. The limited availability of effective therapeutic approaches for stroke emphasizes the crucial role of prevention of risk factors. The global burden associated with type 2 diabetes is large and continues to grow. Convincing epidemiologic data support the role of physical activity in preventing type 2 diabetes. The increasing evidence of physical activity in preventing diabetic complications, including stroke, has generated interest in the molecular basis underlying these beneficial effects. The aim of the present review is to discuss the biological mechanisms underlying the effect of physical activity in preventing stroke in type 2 diabetes.

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  • Exercise primarily lowers hyperglycemia by improving glucose sensitivity and by mechanisms that interfere directly with endothelial metabolism.

    “exercise primarily acts to lower hyperglycemia by improving glucose sensitivity and mechanisms that interfere directly with endothelial metabolism (4).”

    From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [4]

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Authors
Agosti, V., Graziano, S., Artiaco, L., & Sorrentino, G.
Affiliations
Parthenope University of Naples (IT)
Corresponding author
Sorrentino, G.
Venue
Acta Neurologica Scandinavica
Published
2009-04
Volume
119
Issue
4
Pages
213-223
ISSN
  • 0001-6314 (ISSN-L)
  • 1600-0404
OpenAlex
W1974593340
Cited by
25
References
129
Citations by year
2024: 2 · 2020: 4 · 2018: 4 · 2016: 3 · 2015: 2 · 2013: 2 · 2012: 4
FWCI
0.07
Type
journal article
Language
en
Open access
Locations
  • Acta Neurologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • Aisberg (University of Bergamo) (submittedVersion)
  • CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
Funders
  • Ministero della Salute
  • Ministero dell’Istruzione, dell’Università e della Ricerca
  • Regione Campania
  • Regione Lazio
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
physical activity, stroke prevention, type 2 diabetes, biological mechanisms, diabetes mellitus, stroke risk factors, diabetes complications, hypertension, hypercholesterolemia, hyperhomocysteinemia, smoking
MeSH terms
Animals, Diabetes Mellitus, Type 2, Endothelium, Exercise Therapy, Glycogen, Humans, Insulin, Nitric Oxide, Risk Factors, Signal Transduction, Exercise, Muscle, Skeletal, Stroke, Lipid Metabolism, Glucose Transporter Type 4

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